Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Artificial Intelligence and Other Emerging Technologies for a New Era of Chemical and Biological Defense
Discussion Leader: Catharine Bosio (Rocky Mountain Laboratories, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
Brandi Vann (DoD, United States)
"Current Topics in Chemical and Biological Defense"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
Jennifer Nuzzo (Pandemic Center at Brown University School of Public Health, United States)
"Pandemic-Proofing the Future"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Artificial Intelligence and the Modernization of Chemical Synthesis
Discussion Leader: Connor Coley (Massachusetts Institute of Technology, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Francesca Grisoni (Eindhoven University of Technology (TU/e), The Netherlands)
"De Novo Design of Bioactive Molecules With Chemical Language Models"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Luke Rogers (On Demand Pharmaceuticals, United States)
"Pharmacy on Demand: A Case of Arrested Development or Flourishing Adolescence"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Dobrila D. Rudnicki (Program Director, NCATS, NIH, United States)
"A Specialized Platform for Innovative Research Exploration (ASPIRE) – A Collaborative Automated Chemistry, Biological Screening, and AI/ML Approach to Discover New Chemistries Towards Undrugged Biological Targets"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
Timothy Cernak (University of Michigan, United States)
"Chemical Synthesis at the Interface of Data Science"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Brandi Vann (DoD, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Acute Lung Injuries and Acute Respiratory Distress Syndrome in Chemical and Biological Exposures
Discussion Leader: Livia Veress (University of Colorado Anschutz Medical Campus, United States)
7:30 pm - 7:55 pm
Jehan Alladina (Massachusetts General Hospital, United States)
"Novel Biomarkers of Acute Lung Injury"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Satya Achanta (Duke University School of Medicine, United States)
"Phosgene Inhalation Injuries: Biomarkers and Drug Targets"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Bradford Smith (University of Colorado Denver, Anschutz Medical Campus, United States)
"Defining Optimally Lung-Protective Mechanical Ventilation Based on the Alveolar Micromechanics of The Injured Lung"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Matthew McGraw (University of Rochester Medical Center, United States)
"Abnormal Airway Progenitor Cell Responses to Chemical Inhalation Exposures"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Harnessing Physiological Data for Chemical and Biological Exposure Warning
Discussion Leader: Katherine Delaveris (Defense Threat Reduction Agency (DTRA) - A&AS Contractor, Cortek, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Sarah Goodchild (Dstl, United Kingdom)
"Early Detection and Diagnosis of Infection Using Physiological Signatures - ERADICATE"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sara Mariani (Philips Research, United States)
"Wearables and Beyond: Leveraging Physiological Signals to Detect Infection and Chemical Exposure in Warfighters"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Seila Selimovic (Department of Health and Human Services, Biomedical Advanced Research and Development Authority, United States)
"BARDA DRIVe-ing Early Infection Detection – Insights from Wearable Physiological Sensors"
11:00 am - 11:05 am
Discussion
11:05 am - 11:30 am
Rafael Jaimes (MIT Lincoln Laboratory, United States)
"Leveraging big data to Build Robust Models for Early Warning of Biological/Chemical Exposures"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Harshini Mukundan (Lawrence Berkeley National Laboratory, United States)
"Innate Immunity Inspired Pathogen Agnostic Strategies for Biodetection"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Richard Kingsborough (MIT Lincoln Laboratory, United States)
"Pushing the Limits of Low-SWaP-C Chemical Sensors"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Craig Tewell (Sandia National Laboratories, United States)
"Climbing the Ivory Tower — What Role Will You Take in Building Trust in Science?"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Blood Brain Barrier Function, Compromise and Protection
Discussion Leader: Henry VanBrocklin (University of California San Francisco, United States)
7:30 pm - 7:55 pm
Kurt Zinn (Michigan State University, United States)
"PET Imaging and the Blood-Brain Barrier"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Isaac Jackson (Stanford University, United States)
"To Cross, Or Not to Cross: Predicting BBB Penetrance of Novel Imaging Agents Using AI"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Mark Bolding (University of Alabama at Birmingham, United States)
"A Noninvasive Approach to Optogenetics Using Focused Ultrasound Blood Brain Barrier Disruption for the Delivery of Radioluminescent Particles"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
David Scott (Clario, Inc., United States)
"MRI to Assess Blood Brain Barrier Permeability and Disruption"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biomaterials for Chemical and Biological Defense
Discussion Leader: Monica Serban (University of Montana, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Dmitry Shvartsman (Triton Systems, United States)
"Platform Development for the Next Generation of Diagnostic Tools for Chemical and Biological Defense"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Benedetto Marelli (Massachusetts Institute of Technology, United States)
"Biomaterials for Boosting Food Security"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Caterina Lamuta (University of Iowa, United States)
"Bioinspired Artificial Muscles for Underwater Applications"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
Joachim Veit (University of Montana, United States)
"Bioengineered Self-Adherent Skin for Emergency Use"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Countering Antimicrobial Resistance
Discussion Leader: Mark Albrecht (BARDA, United States)
7:30 pm - 7:55 pm
Sean Brady (The Rockefeller University, United States)
"Natural Antibiotics Produced Unnaturally"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Urania Rappo (BiomX, Inc., United States)
"Nebulized Phage Cocktail for the Treatment of Pseudomonas Aeruginosa Pulmonary Infection in Cystic Fibrosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Angela Coulliette-Salmond (Centers for Disease Control and Prevention; U.S. Public Health Service Commissioned Corps, United States)
"Wastewater Surveillance at Healthcare Facilities to Detect Emerging Pathogenic and Antimicrobial Threats"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Kim Lewis (Northeastern University, United States)
"Resistance-Avoiding Antibiotics"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Applications of Synthetic Biology for Chemical and Biological Defense
Discussion Leader: Kristin Omberg (Pacific Northwest National Laboratory, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Gigi Gronvall (Johns Hopkins Center for Health Security, United States)
"Policy Challenges and Opportunities Posed by Synthetic Biology"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Christopher Voigt (Massachusetts Institute of Technology, United States)
"Synthetic Biology Topic"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Kristin Omberg (Pacific Northwest National Laboratory, United States)
"Science at the Confluence of Security and Biology: Challenges and Opportunities"
11:00 am - 11:05 am
Discussion
11:05 am - 11:30 am
George Korch (Johns Hopkins Bloomberg School of Public Health, United States)
"Host-Based Therapeutics Derived from The Interactome; Is This The Next Wave in Biodefense?"
11:30 am - 11:35 am
Discussion
11:35 am - 12:20 pm
Lee Cronin (University of Glasgow, United Kingdom)
"Programming and Securing Chemical Synthesis Robots from Breaking Bad"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Science and Technological Challenges for Digital Biosecurity
Discussion Leader: Nicholas Generous (Los Alamos National Laboratory, United States)
7:30 pm - 7:55 pm
Blake Hovde (Los Alamos National Lab, United States)
"Introducing Concepts in Digital Biosecurity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Sterling Sawaya (GeneInfoSec Inc, United States)
"Protecting Genetic Information with Molecular Cryptography"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Christopher Goes (Sandia National Labs, United States)
"Digital Twins: Modelling Biomanufacturing Networks to Enhance Digital Biosecurity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Nicholas Pattengale (Sandia National Laboratories, United States)
"Public Biodatabase Integrity, Present and Future"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure