SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Taking the Someday and Making it Everyday |
| Keynote address talks: This presentation will provide an overview of the relationship between the research that is being support in chemical and biological terrorism defense and the recent national policies and initiatives that serve to focus these research programs. This will be followed by a scientific presentation that highlights specific opportunities for research on chemical and biological terrorism defense to be integrated into our "everyday" lives. |
| Discussion Leader: Carol Linden (HHS) |
7:40 pm - 8:25 pm | James Le Duc (University of Texas Medical Branch)
"Public Health and Biodefense" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Carol Linden (HHS)
"Policy Framework for Biodefense Programs" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Broad Spectrum Antimicrobials and Antiviral Drugs |
| Discovery of new cellular and metabolic targets in both gram positive and gram negative organisms, and how these might relate to antibiotic resistance. What are new avenues of exploration in discovery and development of antiviral drugs (outside of those targeted to HIV) and are broad spectrum antivirals feasible? |
| Discussion Leader: Vincent Fischetti (Rockefeller University) |
9:00 am - 9:45 am | Vincent Fischetti (Rockefeller University)
"New Approach to Identify Anti-Infectives for B. anthracis" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break / Group Photo |
10:30 am - 11:00 am | R.E.W. Hancock (University of British Columbia)
"Host Defense Peptides as a Novel Anti-Infective Pathway" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Eric Brown (McMaster University)
"Chemical Genomics: Charting Chemical-Genetic Interactions in Bacteria" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Olaf Schneewind (University of Chicago)
"Targeting Bacterial Envelope Assembly for Drug Development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Platform Technologies for Diagnostics |
| Can diagnostic tools for illnesses caused by biological or chemical terrorism threats be integrated into existing technologies and platforms used routinely in the medical and public health communities? |
| Discussion Leader: Peter J. Dailey (Cepheid) |
7:30 pm - 8:00 pm | Peter J. Dailey (Cepheid)
"'Maybe Someday…' is Today -- Experience, Opportunities and Challenges with a 'Dual-Use' Fully-Integrated Diagnostic System" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kelly J. Henrickson (Medical College of Wisconsin)
"Advances in the Molecular Diagnosis of Infectious Diseases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | George Sigal (Meso Scale Diagnostics)
"Bridging the Gap - Developing Products for the Clinical and Bio-Defense Laboratories" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Integration of Chemical and Biological Detection into General Use Platforms |
| Can nanotechnology or other approaches bring the performance characteristics of chemical and biological detection to a high enough level and low enough cost to be integrated into everyday systems? |
| Discussion Leader: Keith Ward (Department of Homeland Security) |
9:00 am - 9:35 am | Andrew Hibbs (Electronic Bio Sciences)
"Basic effects in nanopores and their implication for nanopore-based DNA sequencing" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Anita Goel (Nanobiosym Inc.)
"Precision control of nanomotors that read and write DNA at the single molecule level" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Konstantin Vodopyanov (Stanford University)
"Ultrasensitive Detection of Chemical and Biological Threats Using Fiber-Laser-Based Mid-IR Frequency Comb Spectroscopy" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | G.A. Eiceman (New Mexico State University)
"A small mobility spectrometry platform for combined chemical and biological detection" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Early Host Responses to Biological and Chemical Agents |
| What are novel approaches to determining if someone has been exposed to these agents before they display signs of illness? |
| Discussion Leader: Marti Jett (Walter Reed Army Institute of Research) |
7:30 pm - 7:40 pm | Anup K. Singh (Sandia National Laboratories)
"An Integrated Microfluidic Platform for Studying Innate Immunity Pathways with Single-Cell Resolution for Early Host Responses" |
7:40 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Rasha Hammamieh (Walter Reed Army Institute of Research)
"Genome to Phenome: Integromic Approaches to Define Temporal Network Regulations During Host-Pathogen Interactions" |
8:20 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Sofi Ibrahim (USAMRIID and Rebekah Gundry, Johns Hopkins University School of Medicine)
"Cell Surface Glycoproteomics: Uncovering a hidden proteome to gain insights into host response to monkeypox infection" |
9:00 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Translational Research: Animals to People |
| How can we better understand, based on animal efficacy studies, if a product will work in people as desired? Can mathematical modeling help us? |
| Discussion Leader: Chad Roy (Tulane University) |
9:00 am - 9:50 am | Tom Ficht (Texas A&M University College of Veterinary Medicine)
"Brucella Vaccines: Rodents to Ruminants to Primates" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:20 am | Doug Reed (University of Pittsburgh Medical Center)
"Development of Animal Models for Exposure to Aerosolized Filoviruses" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Aysegul Nalca (USAMRIID, Center for Aerobiological Sciences)
"Orthopox virus animal models: Critical translation from bench to bed side" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | "Magic Bullets": Immunomodulators and Immune Enhancers |
| Will nonspecific, "broad spectrum" drugs allow us to protect against an array of biological threats, both known and new? |
| Discussion Leader: Jacques Banchereau (Baylor Institute for Immunology Research) |
7:30 pm - 8:00 pm | Jacques Banchereau (Baylor Institute for Immunology Research)
"Human Dendritic Cell Subsets" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michel Gilliet (Univ. of Texas MD Anderson Cancer Center)
"Dendritic Cell Activation by Nucleic Acids Coupled with Antimicrobial Peptides" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Damien Chaussabel (Baylor Institute for Immunology Research)
"Blood Transcriptional Profiling" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | "OMICS" for Biological and Chemical Agents |
| What new results in the area of proteomics, genomics, metabolomics can help develop defenses for these threats? |
| Discussion Leader: Thomas Slezak (Lawrence Livermore National Labs) |
9:00 am - 9:50 am | Brett Chromy (Lawrence Livermore National Laboratory)
"From Albuminomics to Zyomyx: An Overview of Omics Science for the Biodefense Researcher" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:20 am | Charles Cantor (Sequenom and Boston University)
"Profiling Microbes and Mixtures by Automated Nucleic Acid Mass Spectrometry" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Lynn Schriml (University of Maryland School of Medicine)
"Challenges to Metadata Warehousing and Integration of 'Omics' Date Repositories" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Screening Strategies: Targets and Opportunities for Intervention |
| Novel approaches to screening peptide libraries; chemical genetic screening for identification of critical pathways involved in pathogenesis of chemical and biological threat agents. |
| Discussion Leader: Sina Bavari (USAMRIID) |
7:30 pm - 8:00 pm | Sina Bavari (USAMRIID)
"Chemical biology-driven approaches to discover host-based therapeutics" |
| Rekha Panchal (USAMRIID)
"Harnessing the power of chemical biology to identify druggable pathways for highly lethal microbial agents" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ramon M. Felciano (Ingenuity Systems)
"Application of computational systems biology to chembio analytics and identification of novel pathogen-directed pathways" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jon Ellman (University of California, Berkeley)
"Substrate Activity Screening: A New Fragment-Based Approach for Pathogen Inhibitor Discovery" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |