SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Synthetic Biology and Bioethics in Chemical & Biological Defense Research |
| Discussion Leaders: Drusilla Burns (Food & Drug Administration), Stephen A. Morse (Centers for Disease Control & Prevention) |
7:40 pm - 8:20 pm | Andrew Ellington (University of Texas, Austin) "Synthetic Biology and Biodefense" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Arturo Casadevall (Albert Einstein School of Medicine) "Dual Use: The Sword that Cuts Both Ways" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Viral Pathogens |
| Discussion Leader: Peter Jahrling (National Institutes of Health / National Institute of
Allergy & Infectious Diseases) |
9:00 am - 9:15 am | Overview by Peter Jahrling |
9:15 am - 9:50 am | Gerd Sutter (University of Munich LMU)
"Smallpox - Latest Developments in Models for Pathogenesis, Prevention, and Treatment" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 11:00 am | Dennis Hruby (SIGA Technologies, Corvallis, OR) "Discovery and Development of a Smallpox Antiviral Drug" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Ralph Baric (University of North Carolina, Chapel Hill) "Synthetic Biology of Viruses - Capabilities and Prospects" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Michael Katze (University of Washington) "Systems Virology - Vision for the Future or a Mirage?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetics and Genomics of Biodefense-Related Pathogens |
| Discussion Leaders: Richard Rest (Drexel University) Jeff Miller (University of California, Los Angeles) |
7:30 pm - 7:35 pm | Overview by Jeff Miller |
7:35 pm - 8:05 pm | Theresa Koehler (University of Texas, Houston)
"Virulence Factor Synthesis and Development in Bacillus anthracis" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Petra Oyston (Defense Science & Technology Laboratory, Porton Down, United Kingdom) "Virulence Associated Genes in Francisella tularensis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | William Nierman (J. Craig Venter Institute, Rockville, MD) "The Quorum Sensing Regulon of Burkholderia pseudomallei and Burkholderia mallei" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host-Microbe Interactions: Immune Suppression / Evasion |
| Discussion Leader: Arturo Casadevall (Albert Einstein School of Medicine) |
9:00 am - 9:15 am | Overview by Arturo Casadevall |
9:15 am - 9:50 am | W. Joost Wiersinga (University of Amsterdam, The Netherlands) "Burkholderia and Immunosuppressive Effects on Cytokine Production in Lungs" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Cosima Baldari (University of Siena, Siena, Italy) "Bacillus anthracis and Host Immune Suppression" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | James Bliska (SUNY Stony Brook) "Modulation of innate immune responses in macrophages by Yersinia pestis" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Joanna Shisler (University of Illinois) "Poxviruses as Teachers of the Primitive Pattern Recognition Response" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | An Inside Job: How Intracellular Pathogens Exploit and Remodel Host Cells to Establish Residence, Subvert Host Defenses, and Promote Transmission |
| Discussion Leader: Steven Blanke (University of Illinois) |
7:30 pm - 7:35 pm | Overview by Steven Blanke |
7:35 pm - 8:05 pm | Jean Celli (NIH/NIAID, Rocky Mountain Laboratories) "Sequential Exploitation of Intracellular Compartments during the Brucella Intracellular cycle" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Michele M. Barry (Howard Hughes Medical Institute, University of Alberta, Canada) "Intracellular Manipulation of Host Cell Responses to Infection" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Geoffrey L. Smith (Imperial College London, United Kingdom) "Repulsion of Superinfecting Virions: A Mechanism for Rapid Virus Spread" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemical Defense and Cutting Edge Research Developments |
| Discussion Leader: Rudolph Johnson (Centers for Disease Control & Prevention) |
9:00 am - 9:15 am | Overview by Rudolph Johnson |
9:15 am - 9:50 am | E. Michael Jakubowski (Edgewood Laboratories, United States Army) "The Development of Advanced Analytical Methods for Biomarkers and Dose Metrics of G and V Nerve Agent Exposure" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Clem Furlong (University of Washington) "Biomarkers of Organophosphate Exposure" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Karen Wahl (Pacific Northwest Labs) "Indicators of Ricin Processing Methods" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Mark Kirk (Department of Homeland Security) "Enhancing Our Nation's Preparedness Against Chemical Threats: Bringing Cutting Edge R&D to the Response Community" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | "Open Mike Session" - Presentations of Selected Science Abstracts |
| Discussion Leader: David Relman (Stanford University) |
7:30 pm - 7:40 pm | Overview by David Relman |
7:40 pm - 7:52 pm | Aleksandr Miklos (Applied Research Laboratories, University of Texas at Austin)
"Computational (re)-Design of Protein Small Molecule Binding Sites" |
7:52 pm - 8:02 pm | Discussion |
8:02 pm - 8:14 pm | K. Jason Kindrachuk (National Institutes of Health)
"Analysis of Differential Host Cell Responses to West African or Central African Monkeypox Virus Infection through Kinome Analysis" |
8:14 pm - 8:24 pm | Discussion |
8:24 pm - 8:36 pm | Brittany Mortensen (University of North Carolina)
"The Role of RipA in Francisella tularensis Virulence and Immune Evasion" |
8:36 pm - 8:46 pm | Discussion |
8:46 pm - 8:58 pm | Matthew Crawford (University of Virginia)
"Identifying Bacterial Targets of CXC Chemokine-Mediated Antimicrobial Activity against Bacillus anthracis" |
8:58 pm - 9:08 pm | Discussion |
9:08 pm - 9:20 pm | Stephanie Suzuki (University of Washington)
"Expression, Purification, and Characterization of Human PON1 Mutants in an Escherichia coli System" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Agricultural Agents of Bioterrorism: Plant Pathogens |
| Discussion Leader: Jacqueline Fletcher (Oklahoma State University) |
9:00 am - 9:15 am | Overview by Jacqueline Fletcher |
9:15 am - 9:50 am | Adam Bogdanove (Iowa State University) "Manipulation of Host Gene Expression by TAL Effector Proteins of Plant Pathogenic Bacteria" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Liliana Cano (The Sainsbury Laboratory, UK) "The Secrets of Crop Killers: Evolution and Function of Filamentous Pathogen Effectors" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Jan Leach (Colorado State University) "Mechanisms of Plant Resistance to Bacterial and Fungal Pathogens" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | June Medford (Colorado State University) "Designing Detector Plants as Inexpensive and Highly Specific Monitors for Explosives, Chemical Weapons and Biological Agents using Synthetic Biology" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Anticipating the Unknown Threat - Cutting Edge Therapeutic Strategies for Biodefense |
| Discussion Leader: Randall Kincaid (Defense Threat Reduction Agency) |
7:30 pm - 7:35 pm | Overview by Randall Kincaid |
7:35 pm - 8:05 pm | Patrick Iversen (AVI BioPharma) "Use of Anti-Sense Oligomer Therapeutics as a Platform for Rapid Development of Biothreat Countermeasures" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Nicholas Valiante (Novartis) "Small Molecule Immune Potentiators (SMIPs) as Broad-Spectrum Countermeasures for Biological Threats" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ronald Germain (National Institutes of Health) "Systems Immunology and Modeling of Host-Pathogen Interactions in Infectious Disease" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |