SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Dual Use and the Intersection of Science and Security |
| Discussion Leader: Jacqueline Fletcher (Oklahoma State University) |
7:40 pm - 8:05 pm | Paul Keim (Northern Arizona University)
"Dual use research of concern - What is it and how do we deal with it"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Koos van der Bruggen (Royal Netherlands Academy of Arts and Sciences)
"Dual use issues - European perspective"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Gerald Epstein (Department of Homeland Security)
"Governance of dual use biotechnology: After more than a decade have we learned anything?"
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9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Responses to Biothreat Agents |
| Discussion Leader: Drusilla Burns (Food and Drug Administration) |
9:00 am - 9:15 am | Drusilla Burns (Food and Drug Administration)
"Overview"
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9:15 am - 9:50 am | Stanley N. Cohen (Stanford University School of Medicine)
"Human genetic variation and how it affects susceptibility to anthrax and other diseases"
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9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 11:00 am | Kim A. Brogden (University of Iowa)
"Antimicrobial peptide modulation of chemokine and proinflammatory cytokine responses: It's all in the timing"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Molly A. Hughes (University of Virginia School of Medicine)
"Chemokine-mediated antimicrobial activity and its role in host defense against Bacillus anthracis"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Michael Shuler (Cornell University)
"Body on a chip - a tool for developing medical countermeasures"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Exposure Analysis |
| Discussion Leader: Clement Furlong (University of Washington School of Medicine) |
7:30 pm - 7:35 pm | Clement Furlong (University of Washington School of Medicine)
"Overview"
|
7:35 pm - 8:05 pm | Judit Marsillach (University of Washington)
"Biomarkers of organophosphorous exposure: A proteomics approach"
|
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Chuck Thompson (University of Montana)
"Design and synthesis of novel organophosphorous agents for PET imaging studies"
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8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Palmer Taylor (University of California, San Diego)
"Novel organophosphate antidotes possessing plasma scavenging capabilities and rapid blood-brain fluxes"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Virulence Mechanisms and Effectors of Plant Pathogens |
| Discussion Leader: Adam Bogdanove (Cornell University) |
9:00 am - 9:15 am | Adam Bogdanove (Cornell University)
"Overview"
|
9:15 am - 9:50 am | Shou-Wei Ding (University of California, Riverside)
"Defense and counter-defense in virus-host interactions"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Mary Beth Mudgett (Stanford University)
"Xanthomonas effector arsenal: Weapons targeting the plant immune system"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Tarek Hewezi (The University of Tennessee, Knoxville)
"The stranglehold of cyst nematode effectors on plant biology"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Ralph Dean (North Carolina State University)
"Insights into fungal pathogenesis: The rice blast story"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Host-Pathogen Interactions |
| Discussion Leader: Steven R. Blanke (University of Illinois) |
7:30 pm - 7:35 pm | Steven R. Blanke (University of Illinois)
"Overview"
|
7:35 pm - 8:05 pm | Ian Glomski (University of Virginia)
"How does Bacillus anthracis invade from the lung: Prison break versus Trojan horse"
|
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Giampietro Schiavo (Cancer Research UK London Research Institute)
"Basic aspects of the axonal transport and transcytosis of clostridial neurotoxins"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Elisabeth Carniel (Institute Pasteur, Paris, France)
"Some insights into the exceptional capacity of Yersinia pestis to cause a disseminated infection"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Detection and Analysis of Chemical Agents and Toxins |
| Discussion Leader: Rudolph Johnson (Centers for Disease Control and Prevention) |
9:00 am - 9:15 am | Rudolph Johnson (Centers for Disease Control and Prevention)
"Overview"
|
9:15 am - 9:50 am | Daan Noort (Netherlands Organization for Applied Scientific Research)
"Innovative methods for unequivocal assessment of exposure to nerve agents based on covalent protein adducts"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Patrick M. McNutt (U.S. Army Medical Research Institute of Chemical Defense)
"Robust derivation of networked cortical neuron cultures for mechanistic characterization of neuromodulatory biotoxins and nerve agents: A physiologically meaningful in vitro model for therapeutic discovery"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Brigitte Dorner (Robert Koch Institute, Center for Biological Security, Germany)
"Biological toxins of potential bioterrorism risk: Challenges for detection technology"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Suzanne R. Kalb (Centers for Disease Control and Prevention)
"Detection and quantification of ricin and ricin activity by mass spectrometry"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Hot Topics Session |
| Discussion Leaders: Randall L. Kincaid (Joint Program Executive Office, U.S. Army) and Richard Rest (Drexel University College of Medicine) |
7:30 pm - 7:40 pm | Randall L. Kincaid (Joint Program Executive Office, U.S. Army) and Richard Rest (Drexel University College of Medicine)
"Overview"
|
7:40 pm - 7:52 pm | Carlee Ashley (Sandia National Laboratories)
"Rapid selection of Nipah and Hendra virus vaccine candidates from a complex, random peptide library displayed on virus-like particles of MS2 bacteriophage" |
7:52 pm - 8:02 pm | Discussion |
8:02 pm - 8:14 pm | Snejana Bakardjieva (Institute of Inorganic Chemistry, ASCR, V.V.I., Czech Republic)
"New inorganic nanostructures for stoichiometric degradation of chemical warfare agents" |
8:14 pm - 8:24 pm | Discussion |
8:24 pm - 8:36 pm | Daniel Gillet (CEA, France)
"Inhibitors of intracellular trafficking active against toxins, viruses and other targets" |
8:36 pm - 8:46 pm | Discussion |
8:46 pm - 8:58 pm | Ian Gut (USAMRICD)
"The functional and mechanistic evaluation of excitotoxicity in mouse embryonic stem cell-derived neurons" |
8:58 pm - 9:08 pm | Discussion |
9:08 pm - 9:20 pm | Sarah Higgins (University of Toronto, Canada)
"Interventions to stabilize the endothelium improve survival following experimental severe life-threatening infectious challenge" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Countermeasure Development |
| Discussion Leader: Petra Oyston (DSTL Porton Down, UK) |
9:00 am - 9:15 am | Petra Oyston (DSTL Porton Down) and Jason Paragas (Defense Threat Reduction Agency)
"Overview"
|
9:15 am - 9:50 am | Geoffrey S. Ginsburg (Duke University Medical School)
"Presymptomatic diagnostics: Triggers to treat following a biological release"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Ali Tavassoli (University of Southhampton, UK)
"Genetic selection of protein-protein interaction inhibitors: A tool for drug discovery"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Eva-Maria Strauch (University of Washington)
"Protein Origami: Design of Antivirals"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Jim Heath (California Institute of Technology)
"The contribution of synthetic biology to the production of medical countermeasures"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biodefense at the Dinner Table |
| Discussion Leader: Kevin Anderson |
7:30 pm - 7:35 pm | Arturo Casadevall (Albert Einstein College of Medicine)
"Overview"
|
7:35 pm - 8:05 pm | Bettina Fries (Albert Einstein College of Medicine)
"Molecular characterization and neutralizing efficiency of staphylococcal enterotoxin B-specific monoclonal antibodies'
|
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Rongsheng Jin (Sanford-Burnham Medical Research Institute)
"How botulinum neurotoxin passes through the gut"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David A. Rasko (University of Maryland School of Medicine)
"Diversity and evolution of pathogenic Escherichia coli: Lessons learned from high-throughput genome sequencing"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |