Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Ever Changing Landscape of Threats to Human Health and Security
Discussion Leader: Steven Blanke (University of Illinois, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Arik Eisenkraft (Institute for Research in Military Medicine, Hebrew University of Jerusalem, Israel)
"OP or Not OP, that Is the Question"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Owain Edwards (CSIRO Land and Water, Australia)
"How Concerned Should We Be About Gene Drive Technologies?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Adam Ruben (Johns Hopkins University, USA)
"Public
Perception of Chemical and Biological Terrorism"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neural Dysfunction: Mechanisms, Detection, and Countermeasures
Discussion Leader: John McDonough (U.S. Army Medical Research Institute of Chemical Defense, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader: Introduction and Perspectives on Emerging Issues and Innovative Solutions for Threat Agents Targeting Neural Function
9:15 am - 9:45 am
Douglas Cerasoli (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Using Novel Enzymes to Protect Against Organophosphorus Toxicity"
9:45 am - 9:55 am
Discussion
9:55 am - 10:15 am
Edwin Vazquez-Cintron (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Intraneuronal Delivery of Single Domain Antibodies for Treatment of Post-Symptomatic Botulism"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Andrew Pickett (Toxin Science Limited, United Kingdom)
"Botulinum Toxin - From Biothreat to Biomedicine"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Pamela Lein (University of California, Davis, USA)
"A Tale of Two Threat Agents: OPs and TETS"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Molly Hughes (University of Virginia, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host Interactions and Responses
Discussion Leader: Manuela Raffatellu (University of California, Irvine, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Introduction and Perspectives on Host Immunity and
Threat Agents
7:45 pm - 8:10 pm
Wyndham Lathem (Institut Pasteur, France)
"Your Own Worst Enemy: How Yersinia pestis Turns the Body Against Itself"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Alexis Kaushansky (Center for Infectious Disease Research, USA)
"Combining Mechanistic and Global Insights to Identify Critical Interactions Between Pathogen and Host"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Timothy Sampson (California Institute of Technology, USA)
"Alternative Roles for CRISPR-Cas Systems in Bacterial Pathogenesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Host Barrier Function and Dysfunction
Discussion Leader: Carolyn Coyne (University of Pittsburgh, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader: Overview and Perspectives on the Host Barriers, and How Biological and Chemical Threat Agents Might Affect Barrier Function
9:15 am - 9:45 am
Debra Laskin (Rutgers University, USA)
"Inflammatory Mechanisms of Lung Injury Induced by Mustard Vesicants"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
Harald Ott (Harvard Medical School, Massachusetts General Hospital, USA)
"Rebuilding the Damaged Lung"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
William Beavers (Vanderbilt University, USA)
"Imaging Mass Spectrometry: Untargeted Molecular Histology at the Host-Pathogen Interface"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Carolyn Coyne (University of Pittsburgh, USA)
"Antimicrobial Signaling at the Maternal-Fetal Interface"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targeting Metabolism
Discussion Leader: Catharine Bosio (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Overview and Perspectives on the the Targeting of Metabolism by Threat Agents
7:45 pm - 8:10 pm
Jean Challacombe (Los Alamos National Laboratory, USA)
"Metabolic Targets: Modeling and Predictions"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Gahl Levy (The Hebrew University of Jerusalem, Israel)
"Nuclear Receptors Control Pro-Viral and Antiviral Metabolic Responses to Hepatitis C Virus Infection"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Michael Lagunoff (University of Washington, USA)
"Targeting Viruses Through Cellular Metabolism"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Extended and Emerging Threats to Human Health
and Security
Discussion Leader: Katrina Campbell (Queen's University Belfast, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader: Perspectives and Overviews on Extended and Emerging Threats to Human Health and Security
9:15 am - 9:45 am
William Schneider (Foreign Disease Program, Agricultural Research Service, USDA, USA)
"CRISPR/Gene Grives: Potential Threats in Plants and Agriculture"
9:45 am - 9:55 am
Discussion
9:55 am - 10:25 am
Townsend Peterson (University of Kansas, USA)
"From WMDs to CMBs: What Creative Malicious Biologists Could Do, but Haven't"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Corey Hudson (Sandia National Laboratories, USA)
"Building Cyberthreat Models for Genomic Security"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Trevor Bedford (Fred Hutchinson Cancer Research Center, USA)
"Real-Time Genomic Surveillance of Pathogen Evolution and Spread"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Looking Ahead: Young Investigator Presentations / Alternative Approaches
Discussion Leader: Thomas Blake (Centers for Disease Control and Prevention, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Perspectives on Emerging Threats and Challenges: A Perspective from the CDC
7:40 pm - 7:55 pm
Ramin Hakami (George Mason University, USA)
"The Art of War: Exosomes as Carrier Pigeons of the Cell to Protect from Bacterial Spread During Infection with Yersinia pestis "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Hilary McCarren (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Combined Stimulation of a2-Adrenoceptors and GABAA Receptors Abruptly Terminates Soman-Induced Status Epilepticus"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
David Franz (NGI, USA)
"Powerful Science: A Tool of Diplomacy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Debobrato Das (University of Washington, USA)
"Engineering Inhalable Polymeric Prodrugs of Ciprofloxacin for Prophylactic andTherapeutic Treatment of Highly-Lethal Pulmonary Francisella tularensis Infections"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Robin Holland (University of Illinois at Urbana Champaign, USA)
"Activating Mitochondrial Quality Control as a Strategy to Combat Mitochondrial Targeted Pathogenic Effectors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Smart Approaches for Detection, Prevention, and Intervention
Discussion Leader: Patrick McNutt (U.S. Army Medical Research Institute of Chemical Defense, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader: The Emergence of Smart Solutions to Threat Agents
9:15 am - 9:40 am
Esther Chang (Georgetown University, USA)
"A Platform Technology Based on a Nanocomplex that Actively Crosses the Blood-Brain Barrier and Its Use in Medical Countermeasures Against Both Chemical and Biological Threat Agents"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
Charles Thompson (University of Montana, USA)
"Interrogation of In Vivo Modes of Action of Positron-Labeled Organophosphates and Antidotes with Dynamic PET Imaging"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Robert Meagher (Sandia National Laboratories, USA)
"You Catch More Flies (and Mosquitoes) with Honey - A New Approach to Automating Surveillance for Arboviruses"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Paula Hammond (Massachusetts Institute of Technology, USA)
"Nanolayered Delivery from Trauma: Delivery Solutions for Field Care Medicine"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Working at the Periphery: Bioengineering-Inspired Solutions for Counteracting Biological and Chemical Threats
Discussion Leader: Patrick Stayton (University of Washington, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Perspectives and Overview of the Capacity of Bioengineering to Meet the Challenges and Opportunities Associated with Existing and Emerging Threats
7:45 pm - 8:10 pm
Nicole Steinmetz (Case Western Reserve University , USA)
"Plant Virus-Based Nanotechnologies"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Bernhard Weigl (Intellectual Ventures Global Good, USA)
"High Performance Lateral Flow Assays as First Line of Defense Against Bioagents"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Daniel Fletcher (University of California, Berkeley, USA)
"Dial 'P' for Pathogen"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure