Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Integration of New Detection Technologies
Discussion Leader: Catharine Bosio (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Juergen Richt (Kansas State University, USA)
"Rift Valley Fever: Development of Mitigation Strategies in Target Animals"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Kevin Yehl (Massachusetts Institute of Technology, USA)
"Engineering Biological Computers"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Paula Vanninen (University of Helsinki, Finland)
"Current and Future Trends in Analysis of Chemical Warfare Agents"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Methods for Countering Antimicrobial Resistance
Discussion Leader: Rushika Perera (Colorado State University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Crystal Jaing (Lawrence Livermore National Laboratory, USA)
"Targeted NGS for Detection of Anti-Microbial Resistance"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Peter Hotchkiss (Sandia National Laboratories, USA)
"The Role of Cooperative Threat Reduction in Chem/Bio Terrorism Defense and Synergies with R&D"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Raga Krishnakumar (Sandia National Laboratories, USA)
"Characterizing and Engineering Mesenchymal Stem Cells for Antimicrobial Therapy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Cassandra Quave (Emory University, USA)
"Innovating Countermeasures for Hypervirulent Multidrug Resistant Pathogens with Botanical Products"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Sina Bavari (United States Army Medical Research Institute of Infectious Diseases, USA)
"Protein-Tyrosine Phosphatases: Host Targets to Counter Bacterial Infection"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Catharine Bosio (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA) and Catherine Branda (Sandia National Laboratories, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Agroterrorism
Discussion Leader: Juergen Richt (Kansas State University, USA)
7:30 pm - 8:00 pm
Steven Blanke (University of Illinois at Urbana-Champaign, USA)
"Exploitation of the Phagolysosome by Bacillus anthracis in Human Cells"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Barbara Drolet (Agricultural Research Service, U.S. Department of Agriculture, USA)
"Transboundary Arboviral Threats to U.S. Agriculture"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Rushika Perera (Colorado State University, USA)
"Metabolite Biomarkers of Emerging Infectious Diseases"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Countermeasures for Pulmonary and Dermatological Chemical Threats
Discussion Leader: Charles Thompson (University of Montana, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Mohammed Athar (University of Alabama at Birmingham, USA)
"Dissecting Complex Molecular Pathogenesis of Warfare Vesicants Arsenicals"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Sven-Eric Jordt (Duke University, USA)
"Chlorine Inhalation Injury in a Large Animal Model: Targets, Biomarkers and Countermeasures"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Kurt Lu (Northwestern University, USA)
"Blocking Immune Activation: A Countermeasure Strategy for Tissue Repair"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Livia Veress (University of Colorado Denver, USA)
"Swine Model of Acute High Dose Sulfur Mustard Inhalation, and Improved Outcome After Rescue with Fibrinolytic Treatment"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leader: Patrick McNutt (U.S. Army Medical Research Institute of Chemical Defense, USA)
7:30 pm - 7:45 pm
Amanda Burkhardt (University of California, Irvine, USA)
"Novel Adjuvant Ststems Elicit Protective Cellular and Humoral Immune Responses Against the Bioterrorism Agent Coxiella burnetti in Polyvalent Vaccine Formulations"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Joseph Fernandez (The Ohio State University, USA)
"Molecular Conformations in the Active Site of Organophosphorus-Aged Acetylcholinesterase: Insights in the Rational Development of Nerve Agent Countermeasures"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Daniel Gillet (CEA Saclay, France)
"The Broad-Spectrum Anti-Pathogen Inhibitor ABMA Delays Trafficking from Late Endosomes to Lysosomes and Modulates the Autophagic Flux"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Stuart Armstrong (University of Liverpool, United Kingdom)
"Plasma Proteomic Profiling of Patients with Haemorrhagic Fever with Renal Syndrome from Puumala and Dobrava Hanatavirus Infections"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Peter Nguyen (Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Robust Synthetic Biology Wearables for Threat Detection"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jennifer Poole (FLIR Detection, USA)
"A Long-Lasting Catalytic Organophosphate Scavenger for Pre-Treatment of Nerve Agent Exposure"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
In Vivo Imaging of Disease
Discussion Leader: Steven Blanke (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Dima Hammoud (National Institutes of Health, USA)
"Molecular Imaging of High Consequence Viral Infections"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
Reed Johnson (IRF, National Institute for Allergy and Infectious Diseases, NIH, USA)
"Infectious Diseases Imaging: Counter Bioterrorism Tools for the 21st Century"
10:25 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Daniel Thorek (Washington University in St. Louis, USA)
"Molecularly Specific Imaging of Infectious Material in Model Systems"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Ian Gut (National Biodefense Analysis and Countermeasures Center / Battelle National Biodefense Institute, USA)
"Insights into the Phenotypic and Virulence Differences Observed in Two Lineages of Burkholderia pseudomallei 1026b"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Forrest Jessop (National Institute of Allergy and Infectious Diseases, NIH, USA)
"IFN-Gamma Induced Mitochondrial Reprogramming to Control F. tularensis "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Wearable Technologies for Early Detection
Discussion Leader: Catherine Branda (Sandia National Laboratories, USA)
7:30 pm - 7:55 pm
Kevin Plaxco (University of California, Santa Barbara, USA)
"Counting Molecules, Dodging Blood Cells: Continuous, Real-Time Molecular Measurements In Situ in the Living Body"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Ronen Polsky (Sandia National Laboratories, USA)
"Microneedle Diagnostics and Transdermal Fluid Sampling Strategies for Real-Time Health and Exposure Monitoring"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Michael Henry (Pacific Northwest National Laboratory, USA)
"SensAlert: Transforming Wearable Sensor Data for Early Warning, Health Surveillance"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Chao Jiang (Stanford University, USA)
"Monitoring Personal Environmental Exposome"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Autonomous and Fieldable Chemical Sensors
Discussion Leader: Thomas Blake (Centers for Disease Control and Prevention, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Richard Ozanich (Pacific Northwest National Laboratory, USA)
"Development of an ASTM International Standard for Guiding Test and Evaluation of Field Detection and Assays for Synthetic Opioids"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Derrick Kaseman (Los Alamos National Laboratory, USA)
"Nuclear Magnetic Resonance at Low-Ultra Low Magnetic Fields for Signature Detection of Chemical Warfare Agents and Emerging Threat Materials"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Charles Lawrence Thomas (Loughborough University, United Kingdom)
"Field Technical Exercise FOCUS: A Preliminary Evaluation of the Integrated Sensing System Test of the TOXI-Triage Concepts of Comprehensive Data Capture Across the Casualty Journey"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Frederique Deiss (Indiana University - Purdue University Indianapolis, USA)
"Electrochemical Detection of Chemical Threat Agents"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
In Vivo Delivery of CRISPR Medical Countermeasures and Stem-Cell-Based Countermeasures
Discussion Leader: Anup Singh (Sandia National Laboratories, USA)
7:30 pm - 7:55 pm
Benhur Lee (Icahn School of Medicine at Mount Sinai, USA)
"Sendai Virus Delivery of CRISPR/Cas Machineries for Highly Efficient Gene Editing in Hematopoietic Stem Cells, Myeloid Cells and Dendritic Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Philip Santangelo (Georgia Institute of Technology, USA)
"Synthetic mRNA Based Expression of Activatable RNAses as Tools for Treating RNA Virus Infections"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
David Segal (University of California, Davis, USA)
"Genetic and Epigenetic Engineering Opportunities and Challenges for Biodefense"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Charles Thompson (University of Montana, USA)
"Evaluation of Positron Emission Tomography Tracers Based on Organophosphorus Chemical Threats and Countermeasures"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure