| Session I. Sunday Evening | GPCR Transduction |
Discussion Leader: Michael Chorev (Harvard Medical School, Boston, MA)
- Oleg Kisselev (St. Louis University, St. Louis, MO) - C-terminal Peptides from G-Proteins - Insights into Transduction
- Thomas P. Sakmar (Rockefeller University, New York, NY) - Mapping GPCR-G Protein Interactions
- Henry I. Mosberg (University of Michigan, Ann Arbor, MI) - Modeling and Model Validation of G-Protein Receptors
| Session II. Monday Morning | Therapeutic Opportunities/Signaling |
Discussion Leader: Garland Marshall (Washington University, St. Louis, MO)
- Christiane Garbay (Université Paris V, Paris, France) - Design of Inhibitors of Grb2, Essential for Ras Signaling
- Graham Cotton (Rockefeller University, NYC) - Protein-based Fluorescent Biosensors to Probe Signaling
- Robert J. Lutz (Apoptosis Technologies, Cambridge, MA) - Peptide Motifs in Apoptosis
- William Shakespeare (Ariad Pharmaceuticals, Cambridge, MA) - Structure Based Design of SH2 Inhibitors: Novel Osteoclast Selective Nonpeptide Ligands as Antiresorptive Agents
| Session III. Monday Evening | Ligation/Inteins |
Discussion Leader: Steve Kent (Gryphon Sciences)
- Francine B. Perler (New England Biolabs, Beverly, MA) - Inteins - Chemistry and Biology of Protein Splicing
- James Tam (Vanderbilt University, Nashville, TN) - Protein Synthesis Mimicking Intein Splicing
- Phil Dawson (Scripps Research Institute, La Jolla, CA) - Chemical Ligation: An Enabling Tool for Protein-mimetic Chemistry
- Antonello Pessi (IRBM, Pomezia, Italy) - Chemical Ligation with Fmoc Chemistry
| Session IV. Tuesday Morning | Biomaterials/Novel Applications |
Discussion Leader: Jeff Kelly (Scripps Research Institute, La Jolla, CA)
- Joanna Long (University of Washington, Seattle, WA) - Solid State NMR Studies of Peptides Absorbed on Surfaces
- Neville Boden (University of Leeds, Leeds, England) - Exploiting Peptide Self-Assembly - Novel Tapes, Fibrils, Fibers
- Christopher R. Lowe (University of Cambridge, Cambridge, England) - Synthesis of Peptidomimetics for Affinity Chromatography
- Victor Hruby (University of Arizona) - Direct Studies of Receptor Structural Changes Accompanying Agonist/Antagonist Binding to Opioid Receptors
| Session V. Tuesday Evening | Targeting/Trafficking |
Discussion Leader: Richard Houghten (Torrey Pines Research Institute)
- Jonathan Rothbard (Stanford/Cellgate, Palo Alto, CA) - Use of short polymers of arginine to facilitate transcutaneous delivery of immunosupressives resulting in topical inhibition of cutaneous inflammation
- Paul Wender (Stanford University, Palo Alto, CA) - Design and synthesis of analogs of HIV at 49-57 that demonstrate enhanced cellular uptake
- Yao-Zhong Lin (Vanderbilt University, Nashville, TN) - Intracellular Delivery and Targeting of Peptides and Proteins
| Session VI. Wednesday Morning | Chemistry-Peptides/Peptidomimetics |
Discussion Leader: Jane Aldrich (University of Maryland, Baltimore, MD)
- Jan Kihlberg (University of Umea, Umea, Sweden) - Peptidomimetic Inhibitors of Bacterial Pilus Assembly
- Gaetan Ladouceur (Bayer, West Haven, CT) - Nonpeptidal Glucagon Antagonists
- Thomas Gadek (Genentech, South San Francisco, CA) - ICAM Mimetics as Immunomodulatory Agents
- Stephen Hanessian (Université de Montréal, Montréal, Canada) - Design and Synthesis of Enzyme Inhibitors
| Session VII. Wednesday Evening | Proteomics/Technology |
Discussion Leader: Mike Pirrung (Duke University, Durham, NC)
- Tom Kodadek (UT Southwestern Medical School, Dallas, TX) - Genetic Selection of Peptides Showing Oligomerimization in vivo
- Marc Vidal (MGH Cancer Center, Charleston, MA) - Protein interaction mapping in C. elegans using forward and reverse two-hybrid systems
- Sandra Steiner (Large Scale Biology Corporation, Rockville, MD) - Applications of Proteomics to Preclinical Toxicology Assessment
| Session VIII. Thursday Morning | Synzymes/Modeling |
Discussion Leader: Antonello Pessi (IRBM, Pomezia, Italy)
- Jay Ponder (Washington University, St. Louis, MO) - Global Optimization in Peptide Design
- Don Hilvert (Federal Institute of Technology (ETH), Zurich, Switzerland) - Redesigning Enzyme Topology by Directed Evolution
- Donald Low (Gryphon Biosciences, San Francisco, CA) - Metalloprotein Engineering by Chemical Synthesis
- Dennis Riley (MetaPhore Pharmaceuticals, St. Louis, MO) - Computer-Aided Design of Superoxide Dismutase Mimetics - Chemistry and Preclinical Pharmacology
| Session IX. Thursday Afternoon | Vincent duVigneaud Award Symposium |
Awardees:
- Richard A. Houghten - Parallel solid phase synthesis, mixture-based combinatorial libraries, positional scanning deconvolution and libraries from libraries--tools for basic research and drug design
- Charles M. Deber - Peptide Models of Protein Structure in Membranes
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