| SUNDAY |
| 1:00 p.m. - 6:00 p.m. | Arrival, Conference Registration, Hotel Check-in |
| 6:00 p.m. - 7:00 p.m. | Dinner |
| 7:30 p.m. - 9:30 p.m. | KEYNOTE ADDRESSES |
| Chairs: Jeffery W. Kelly, Scripps & Victor J. Hruby, University of Arizona
|
| 7:30 p.m. - 8:30 p.m. | Peter G. Schultz, Scripps
Functional Molecules: A Lesson from Nature |
| 8:30 p.m. - 9:30 p.m. | Jim Wells, Sunesis
Site Directed Drug Discovery at Signalling Interfaces |
| 9:30 p.m. | Welcoming Reception/Wine & Hor's Douvres
(sponsored by PolyPeptide Laboratories) |
| MONDAY |
| 7:30 a.m. - 8:30 a.m. | Breakfast |
| 9:00 a.m. - 12:30 p.m. | PEPTIDES & PROTEOMICS |
| Chair: Jean A. Chmielewski, Purdue |
| 9:00 a.m. - 9:45 a.m. | David Russell, Texas A&M
Ion Mobility Separations and Mass Spectrometry
in Proteomics
|
| 9:45 a.m. - 10:30 a.m. | Matthew Bogyo, UCSF
Proteomics Using Fluorescence Technology |
| 10:30 a.m. | Coffee Break & Conference Photo |
| 11:00 a.m. - 11:45 a.m. | Ben Cravatt, Scripps
Temporal and Spacial Characterization of Functional Enzymes |
| 11:45 a.m. - 12:30 p.m. | Duncan McRee, Syyrx
High Throughput Structure Determination |
| 12:30 p.m. | Lunch |
| 1:30 p.m. - 4:30 p.m. | Free Time |
| 4:30 p.m. - 6:00 p.m. | Poster Session/Wine & Hor's Douvres |
| 6:00 p.m. | Dinner |
| 7:30 p.m. - 9:45 p.m. | THE CHEMISTRY & BIOLOGY OF PEPTIDES/PROTEINS & MEMBRANES |
| Chair: Charles Deber, Toronto |
| 7:30 p.m. - 8:15 p.m. | Geoff Chang, Scripps
Structure of MsbA: A homolog of the multidrug resistance ABC Transporters |
| 8:15 p.m. - 9:00 p.m. | Steve White, University of California, Irvine
Peptide/Membrane Interactions and Function |
| 9:00 p.m. - 9:45 p.m. | Reza Ghadiri, Scripps
Peptide Nanotubes & Antimicrobials |
| TUESDAY |
| 7:30 a.m. - 8:30 a.m. | Breakfast |
| 9:00 a.m. - 12:30 p.m. | DELIVERY OF PEPTIDES & PROTEINS |
| Chair: Teruna Siahaan, University of Kansas |
| 9:00 a.m. - 9:45 a.m. | John Patton, Inhale Therapeutics
Inhalation Strategies for the Delivery of Peptides and Proteins |
| 9:45 a.m. - 10:30 a.m. | Viren Sarin, Eli Lilly
Pulmonary Drug Development Strategies at a Big Pharma |
| 10:30 a.m. | Coffee Break |
| 11:00 a.m. - 11:45 a.m. | Andrea Leone Bay, Emisphere Technologies
Progress in the Oral Delivery of Peptides and Proteins |
| 11:45 a.m. - 12:30 p.m. | Teruna Siahaan, U Kansas
Modulation of Cellular Tight Junctions to Enhance Paracellular Transport of Peptides and Peptidomimetics |
| 12:30 p.m. | Lunch |
| 1:30 p.m. - 6:00 p.m. | Free Time |
| 2:00 p.m. - 5:00 p.m. | Whale Watching (optional) |
| 6:00 p.m. | Dinner |
| 7:30 p.m. - 9:45 p.m. | PEPTIDE SIGNAL TRANSDUCTION & GENETICS |
| Chair : Carrie Haskell-Luevano, University of Florida |
| 7:30 p.m. - 8:15 p.m. | Ramesh C. Patel, Clarkson University
Subtype Specific Somatostatin Oligomerization of Somatostatin Receptors Induced By Ligand Binding in Live Cells |
| 8:15 p.m. - 9:00 p.m. | Ismaa Sudaf Forooqi, University of Cambridge, England
Melanotropins and Melanocortin Receptor Deficiencies, Human Obesity and Genetics |
| 9:00 p.m. - 9:45 p.m. | Shubh Sharma, Palatin Technologies
MIDAS: Transforming Peptide Ligands for GRCRs Into Biological Leads |
| WEDNESDAY |
| 7:30 a.m. - 8:30 a.m. | Breakfast |
| 9:00 a.m. - 12:30 p.m. | BIOPHYSICAL METHODS IN PEPTIDE AND PROTEIN RESEARCH |
| Chair: Robert Hodges, University of Colorado |
| 9:00 a..m. - 9:45 a.m. | Jacob Schaefer, Washington University
Solid State NMR and Conformational Analysis |
| 9:45 a..m. - 10:30 a..m. | Dale F. Mierke, Brown University
Peptide-G Protein Receptor Interactions |
| 10:30 a..m. | Coffee Break |
| 11:00 a.m. - 11:45 a.m. | Gordon Tollin, University of Arizona
Coupled Plasmon Waveguide Resonance Spectroscopy to Examine Peptide-Membrane Receptor Interactions |
| 11:45 a.m. - 12:30 p.m. | Free Time |
| 12:30 p.m. | Lunch |
| 1:30 p.m. - 4:30 p.m. | Free Time |
| 4:30 p.m. - 6:00 p.m. | Poster Session/Wine & Hor's Douvres |
| 6:00 p.m. | Dinner |
| 7:30 p.m. - 9:45 p.m. | PEPTIDE & PEPTIDOMIMETIC DRUG DESIGN & DEVELOPMENT |
| Chair: Bruce Maryanoff , Johnson &
Johnson |
| 7:30 p.m. - 8:15 p.m. | Murray Goodman University of California, San Diego
Peptidomimetic Building Blocks for Drug Design |
| 8:15 p.m. - 9:00 p.m. | Bruce Maryanoff, Johnson & Johnson
Design of Discovery and Biological Characterization of Peptide-mimetic Antagonists for the Thrombin Receptor (PAR-1) |
| 9:00 p.m. - 9:45 p.m. | Michael Verlander, Polypeptide Laboratories
Large Scale Synthesis of Peptide Drugs |
| THURSDAY |
| 7:30 a.m. - 8:30 a.m. | Breakfast |
| 9:00 a.m. - 12:30 p.m. | YOUNG INVESTIGATOR SYMPOSIUM |
| Chairs - Murray Goodman, University of California, San Diego & Arno Spatola, University of Louisville
Peptidomimetic Building Blocks for Drug Design |
| 9:00 a.m. - 9:45 a.m. | Peter Seeberger, MIT
Design Synthesis and Applications of Peptide Conjugates |
| 9:45 a.m. - 10:30 a.m. | Evan Powers, Scripps
Interfacial Assembly of Soluble Peptides |
| 10:30 a.m. | Coffee Break |
| 11:00 a.m. - 11:45 a.m. | Dewey McCafferty, University of Pennsylvania
Combating Bacterial Resistance to Antibiotics |
| 11:45 a.m. - 12:00 p.m. | Indraneel Ghosh - Yale
University/University of Arizona
"Antiparallel Leucine Zipper Directed Protein Reassembly: Application to the Green Fluorescent Protein" |
| 12:00 p.m. - 12:15 p.m. | Haim Tsubery - Weizman Institute of
Science
"A New Approach to Prolonging the Half Life of Peptide and Protein Drugs In Vivo" |
| 12:15 p.m. - 12:30 p.m. | Michelle Trester-Zedlitz - The Rockefeller
University
"Solid Phase Synthesis, Cross-Linking and Mass Spectrometry: An Integrated Approach for Exploring Protein Interactions" |
| 12:30 p.m. | Lunch |
| 1:30 p.m. - 6:00 p.m. | Free Time |
| 6:00 p.m. | Dinner |
| 7:30 p.m. | DU VIGNEAUD AWARD SYMPOSIUM |
| du Vigneaud Award Address #1:
Robert Hodges, University of Colorado |
| du Vigneaud Award Address #2:
Horst Kessler, Tech. University, Munich |
