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Chemistry and Biology of Peptides

Gordon Research Conference

February 17 - 22, 2008
Chairs Carrie Haskell-Luevano and Kit S. Lam
Vice Chairs Samuel H. Gellman and Mark R. Spaller
Ventura Beach Marriott
2055 Harbor Boulevard
Ventura, California, United States
 Venue and Travel Information

Conference Description

The 2008 "Peptides: Biology & Chemistry of" GRC will present the most recent advances in the field of peptides and peptide-related science. We anticipate an exciting meeting with sessions focused on infectious diseases, material sciences and nanotechnology, folding and dynamics, new chemistry approaches in peptide sciences, chemical biology and molecular imaging, peptide/protein design strategies, ligand-receptor interactions, as well as a wide array of topics to be included in poster and oral presentations selected from submitted abstracts.

We strongly encourage all participants to present their most recent findings or results as a poster. In the past poster sessions have been lively exchanges of information and ideas. We have set aside ample time for poster sessions and will select a number of posters for short oral presentations during the conference.

We recommend early application to the Peptides GRC as attendance is limited. We welcome applications from graduate students and young postdoctoral scientists.

Conference Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
and C. Haskell-Luevano and K. Lam
7:40 pm - 9:30 pm KEYNOTE ADDRESSES
7:40 pm - 8:25 pmVictor J. Hruby (University of Arizona)
"Placing Peptide Science at the Forefront of Drug Discovery, Design and Development"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pmPeter G. Schultz (The Scripps Research Institute)
"Synthesis at the Interface of Chemistry and Biology"
9:20 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm PEPTIDE AND PROTEIN DESIGN STRATEGIES
Discussion Leader: Samuel H. Gellman (University of Wisconsin)
9:00 am - 9:25 am Jerry "Ryan" Holder (Amgen)
"Design and Synthesis of Calcitonin-Gene Related Peptide (CGRP) Antagonists"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amHenry I. Mosberg (University of Michigan)
"Structure-Based Design of Conformationally Constrained Peptide Ligands for mu, delta, and kappa Opioid Receptors, Employing the Same (More or Less) Scaffold"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amMichael Pennington (Bachem Bioscience Inc.)
"Optimizing ShK: A Potassium Channel Blocking Peptide Derived from the Sea Anemone Stichodactyla helianthus, for Clinical Development"
11:05 am - 11:10 am Discussion
11:15 am - 11:30 am Group Photo
11:35 am - 12:00 pm Charles M. Deber (University of Toronto)
"Design of Peptide Models of Membrane Protein Folding"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Poster Presentation: Robin Polt (University of Arizona)
"Glycopeptides as CNS Drugs"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm FOLDING AND DYNAMICS
Discussion Leader: Gouri S. Jas (Baylor University)
7:30 pm - 7:55 pmKrzysztof Kuczera (University of Kansas)
"Peptide Structure, Dynamics and Thermodynamics: Simulations versus Experiment"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmPeter J. Steinbach (National Institutes of Health)
"Peptide Structure Prediction: Energetics and Conformational Searching"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Presentation: Gouri S. Jas (Baylor University)
"Kinetics and Mechanisms of α-Helix, β-Hairpin and Fast Folding Protein Formation"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmCharles L. Brooks III (Scripps Research Institute)
"pH-Dependent Folding and Misfolding"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm LIGAND-PROTEIN INTERACTIONS
Discussion Leader: Charles M. Deber (Hospital for Sick Children / University of Toronto)
9:00 am - 9:25 amDennis A. Dougherty (California Institute of Technology)
"Using Unnatural Amino Acids to Probe Neuroreceptors and Ion Channels"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amMaria Bednarek (Merck)
"Ligands for Melanocortin Receptors"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amMichael Chorev (Harvard Medical School)
"Inhibition of Translation Initiation by Targeting eIF4E/eIF4G Interaction"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 amFred Naider (College of Staten Island, CUNY)
"Using Biophysical and Biochemical Approaches to Follow Domain Movements During GPCR Activation"
11:35 am - 11:45 am Discussion
11:45 am - 12:10 pm Richard DiMarchi (Indiana University)
"Optimization of Glucagon for Clinical Development as an Agonist, and as an Antagonist"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Presentation: Annette Beck-Sickinger (Leipzig University)
"Artificial Chemokines-Combining Chemistry and Molecular Biology for the Elucidation of Function of Interleukin 8"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / Optional Excursion
6:00 pmDinner
7:30 pm - 9:30 pm INFECTIOUS DISEASES
Discussion Leader: Robert S. Hodges (University of Colorado at Denver)
7:30 pm - 7:55 pmJean Chmielewski (Purdue University)
"Designer Collagen Triple Helix Peptides"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmRobert S. Hodges (University of Colorado at Denver)
"Inhibition of SARS-Coronavirus Infection by Peptides and Antibodies"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Presentation: Antonello Pessi (MRL Peptide Center of Excellence, Merck)
"Membrane Targeting of an HIV-1 Peptide Inhibitor Dramatically Increases Antiviral Potency"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmEhud Gazit (Tel Aviv University)
"Self-Assembly of Short Aromatic Peptides: From Amyloid Nano-Fibrils to Nanotechnology"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NEW CHEMISTRY APPROACHES IN PEPTIDE SCIENCE
Discussion Leader: Fernando Albericio (University of Barcelona)
9:00 am - 9:25 amJonathan A. Ellman (University of California, Berkley)
"Substrate Activity Screening: A New Fragment-Based Method for Inhibitor Discovery"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amScott J. Miller (Yale University)
"Peptide-Based Catalysts for Asymmetric Organic Synthesis"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amRichard Houghten (Torrey Pines Institute)
"The Use of Volatilizable Solid Phase Supports in the Synthesis of Peptides and Peptidomimetcs"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 amFernando Albericio (University of Barcelona)
"New Approaches for the Solid-Phase Synthesis of Complex Peptides"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Poster Presentation: Scott Lokey (University of California, Santa Cruz)
"Selective On-Resin N-Methylation of cyclic Peptides Yields Highly Membrane Permeable Scaffolds"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:30 pmBusiness Meeting
Samuel H. Gellman (University of Wisconsin) and Mark Spaller (Brown University)
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm KEYNOTE AWARD LECTURES
Discussion Leader: Richard Houghten (Torrey Pines Institute)
7:30 pm - 8:20 pm Jeff Kelly (The Scripps Research Institute)
"Using Organic chemistry, Peptide Chemistry, and Physical Chemistry to Understand the Energetics of Protein Folding"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm Tom Muir (Rockefeller)
"Testing the ‘Histone Code’ Hypothesis Using Synthesis"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm CHEMICAL BIOLOGY AND MOLECULAR IMAGING
Discussion Leader: Mark Spaller (Brown University)
9:00 am - 9:25 amYvonne Angell (Affymax Inc.)
"Discovery and Development of Erythropoiesis-Stimulating Agent (ESA) Hematide™"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amXiaoyuan "Shawn" Chen (Stanford)
"Peptide Probes for Molecular Imaging"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amThomas Kodadek (UT-Southwestern Medical Center)
"Monitoring and Manipulating the Proteome With Peptoids"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 amMark Spaller (Brown University)
"Chemical Probes for Synaptic Proteins: PDZ Domain Inhibitors as Neuroprotective Agents"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Poster Presentation: Wenwu Xiao (University of California, Davis)
"In vivo Targeting Alpha3 Integrin of Brain Tumor with Ligand Identified by One Bead One Compound Library"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Poster Presentation: Frank Mari (Florida Atlantic University)
"Venturing with the Molecular Diversity of the Venom of Cone Snails: From Small Conopeptides to Conoproteins"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Presentation: Michael Beyermann (Leibniz-Institute of Molecular Pharmacology)
"Synthesis of Multiple-Branched and Cyclic Protein Mimics Using Recombinant, Chemical and Enzymatic Techniques"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm MATERIAL SCIENCE AND NANOTECHNOLOGY
Discussion Leader: Hiroshi Matsui (Hunter College)
7:30 pm - 7:55 pmGregg Fields (Florida Atlantic University)
"Exosite Probes and Inhibitors of Matrix Metalloproteinases"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmMorley Stone (Air Force Research Laboratory)
"Defense Applications of Peptide-Based Research: New Tools for Materials Science and Diagnostics"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Presentation: Katharina Welser (University of Nottingham)
"Switch the Light On: Novel Polymeric Protease Responsive Nanoprobes (PPRNs) Based on Fluorogenic Coumarin Peptide Substrates"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmHiroshi Matsui (Hunter College)
"How Can Biomimetics Impact Device Fabrication and Material Synthesis"
9:20 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Chair’s Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Conference Links

Conference History
Additional Fee Info

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July 14 - 19, 2024


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