SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff, S. Gellman and M. Spaller |
7:40 pm - 9:30 pm | KEYNOTE ADDRESSES: PUSHING THE BOUNDARIES OF PEPTIDE SCIENCE |
7:40 pm - 8:25 pm | Lila Gierasch
"The In Vivo Protein Folding Landscape" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | William DeGrado (University of Pennsylvania)
"Membrane-active Peptides and Peptide Mimics" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | PEPTIDE ASSEMBLY |
| Discussion Leader: Hanna Rapaport (Ben-Gurion University) |
9:00 am - 9:25 am | Joel Schneider (University of Delaware)
"Enabling Therapeutic Delivery via Peptide Self Assembly" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dek Woolfson (Bristol University)
"10 years in the Sticks: Learning About Peptide Self-assembly Through Design" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Amy Keating (Massachusetts Institute of Technology)
"Elucidating Specificity Determinants in Bcl-2 Family Protein-Peptide Interactions" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Samuel Stupp (Northwestern University)
"Supramolecular and Hierarchical Architectures of Peptide Amphiphiles" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Poster Presentation: Bradley Nilsson (University of Rochester)
"Co-Assembly and Self-Sorting Behavior in Peptide Self-Assembly" |
12:00 pm - 12:10 pm | Poster Presentation: Richard Cheng (National Taiwan University)
"Effect of Highly Fluorinated Amino Acids on Protein Secondary Structure Stability" |
12:10 pm - 12:20 pm | Poster Presentation: Jonathan Lai (Albert Einstein College of Medicine)
"Dissecting and Engineering High-Affinity Antibody-Antigen Interactions: Application to Viral Epitopes" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ANTIMICROBIAL PEPTIDES |
| Discussion Leader: Luisa Bracci (University of Siena) |
7:30 pm - 7:55 pm | Tom Ganz (UCLA)
"Small Peptide Mimics of the Iron Regulatory Hormone Hepcidin" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Yechiel Shai (Weizmann Institute)
"Mimicking Host-Defense Antimicrobial Peptides and Lipopeptides to Combat Bacteria, Fungi and Cancer" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Poster Presentation: Alessandro Pini (University of Siena)
"A Novel Tetrabranched Antimicrobial Peptide that Neutralizes Bacterial Lipopolysaccharide and Prevents Septic Shock in vivo" |
8:50 pm - 9:15 pm | Jared Silverman (Cubist Pharmaceuticals)
"Mechanism of Action of the Lipopeptide Antibiotic Daptomycin: Studies in Artificial Membranes and Bacterial Cell Biology" |
9:15 pm - 9:25 pm | Discussion |
9:30 pm | Poster Session I |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PEPTIDE-BASED MEDICINAL CHEMISTRY |
| Discussion Leader: Teresa Kubiak (Pfizer Inc.) |
9:00 am - 9:25 am | Les Miranda (Amgen)
"Chemistry, Biology, & Structure of Hepcidin" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dean Madden (Dartmouth Medical School)
"The CAL PDZ Domain: A Therapeutic Target for Cystic Fibrosis" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Kurt Deshayes (Genentech)
"The Development of Peptide-based Tools for the Analysis of Angiogenesis" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Soumitra Ghosh (Amylin Pharmaceuticals)
"Peptide-based Therapeutics for Obesity and Diabetes" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Poster Presentation: Jutta Eichler (University of Erlangen-Nuremberg)
"Synthetic Mimicry of the CD4 Binding Site of HIV-1 gp120 for the Design of Immunogens" |
12:00 pm - 12:10 pm | Poster Presentation: Scott Lokey (University of California, Santa Cruz)
"Selective, On-resin N-Methylation of Cyclic Peptides and Implication for Design of Membrane Permeable Scaffolds" |
12:10 pm - 12:20 pm | Poster Presentation: Giovanna Ghirlanda (Arizona State University)
"Structure-based Design of Artificial Lectins" |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Excursion |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PEPTIDES & SYNTHESIS |
| Discussion Leader: Michael Carrasco (Santa Clara University) |
7:30 pm - 7:55 pm | Jeffrey Bode (University of Pennsylvania)
"The Ketoacid-hydroxylamine Amide Formation as a General Method for Peptide Ligation" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Helma Wennemers (University of Basel)
"Peptides as Asymmetric Catalysts and Templates for the Formation of Silver Nanoparticles" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Poster Presentation: Andrei Yudin (University of Toronto)
"Macrocyclization of Linear Peptides Enabled by Unprotected Amino Aldehydes" |
8:50 pm - 9:15 pm | Ronald Raines (University of Wisconsin)
"Stereoelectronic Effects on Peptide and Protein Conformation" |
9:15 pm - 9:25 pm | Discussion |
9:30 pm | Poster Session I |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PEPTIDES IN MEMBRANES & PHYSICAL ANALYSIS |
| Discussion Leader: Nick Fisk (Colorado State University) |
9:00 am - 9:25 am | Donald Engelman (Yale University)
"Biophysics and Biological uses of a pH triggered Transmembrane Insertion Peptide: pHLIP" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Stephen Martin (University of Texas at Austin)
"Correlating Structure and Energetics in Protein-Ligand Interactions: Paradigms and Paradoxes" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Mei Hong (Iowa State University)
"High-Resolution Structure of the Influenza M2 Protein in Lipid Bilayers from Solid-State NMR" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Karen Fleming (Johns Hopkins University)
"Folding Membrane Proteins into Lipid Bilayers" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Poster Presentation: Roman Manetsch (University of South Florida)
"Kinetic Target-Guided Synthesis for the Identification of Bcl-xL-Protein Interaction Modulators" |
12:00 pm - 12:30 pm | Business Meeting |
| Maria Bednarek (MedImmune) and Fred Naider (College of Staten Island, CUNY) |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BIOLOGICAL APPLICATIONS |
| Discussion Leader: Jonathan Lai (Albert Einstein College of Medicine) |
7:30 pm - 7:55 pm | Sachdev Sidhu (University of Toronto)
"Natural and Synthetic PDZ Domains" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Hiroaki Suga (University of Tokyo)
"Ribosomal Synthesis of Natural Product-like Non-standard Peptides" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | David Lawrence (University of North Caroline)
"Scrutinizing the Secrets of Cell Signaling with Peptide-Based Probes" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Presentation: Jaehoon Yu (Seoul National University)
"Amphiphilic Peptides Against RNA Hairpins" |
9:30 pm | Poster Session II |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PEPTIDE ENGINEERING |
| Discussion Leader: Scott Lokey (University of California, Santa Cruz) |
9:00 am - 9:25 am | Paramjit Arora (New York University)
"Biomolecular Recognition with Artificial Alpha Helices" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Beate Koksch (University of Berlin)
"Peptide Models to Study Aggregation" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | John Robinson (University of Zurich)
"Design and Applications of Protein Epitope Mimetics" |
11:05 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Hanna Rapaport (Ben-Gurion University)
"Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic α/β-Peptides at the Air-Water Interface" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Poster Presentation: James Nowick (University of California, Irvine)
"Exploring beta-Sheet Structure and Interactions with Chemical Model Systems" |
12:15 pm - 12:25 pm | Poster Presentation: Vikas Nanda (University of Medicine and Dentistry of New Jersey)
"Computational Design of Collagen Peptide Self Assembly" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE LECTURES |
| Discussion Leaders: Maria Bednarek (MedImmune) and Fred Naider (College of Staten Island, CUNY) |
7:30 pm - 8:20 pm | Phil Dawson (Scripps Research Institute)
"Chemoselective Strategies for the Synthesis and Labeling of Proteins" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Reza Ghadiri (Scripps Research Institute)
"Systems Chemistry" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Chair's Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |