SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynotes in Peptide Design and Engineering |
7:40 pm - 8:20 pm | Robin Offord (Mintaka Foundation for Medical Research, Switzerland)
"Peptides and Proteins: Playing Variations on Mother Nature's Theme" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | David Baker (University of Washington, USA)
"Design of Protein Structures, Functions and Assemblies" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biomimetics of Peptide and Protein Structure and Function |
| Discussion Leaders: Laura Kiessling (University of Wisconsin-Madison, USA) and Joshua Kritzer (Tufts University, USA) |
9:00 am - 9:25 am | Sam Gellman (University of Wisconsin-Madison, USA)
"Mimicry of Polypeptide Recognition Surfaces with Peptidic Foldamers" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jennifer Cochran (Stanford, USA)
"Engineered Cystine Knot Peptide Conjugates for Cancer Imaging and Therapy"
|
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | Vince Pecoraro (University of Michigan, USA)
"De Novo Metalloprotein Design" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Roman Jerala (National Institute of Chemistry, Ljubljana, Slovenia)
"Designed Nanostructures Based on Concatenated Coiled-Coil Building Modules" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Adam Urbach (Trinity University, USA)
"Targeting the Terminus for Site-Specific Recognition, Sensing and Protection of Peptides and Proteins"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Macrocyclic Peptide Discovery |
| Discussion Leaders: Kurt Deshayes (Genentech Inc.) and Alethea Tabor (University College, London) |
7:30 pm - 7:55 pm | David Craik (University of Queensland, Australia)
"Going Round in Circles to Make Peptide Drugs" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Patrick Reid (PeptiDream, Japan)
"PeptiDream's PD Platform: Innovative Peptide Discovery Platform" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Christian Heinis (Bicyclic Therapeutics, UK)
"Phage Selection of Bicyclic Peptides" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Intervening in Biological Processes |
| Discussion Leaders: Jennifer Cochran (Stanford, USA) and Giovanna Ghirlanda (Arizona State University, USA) |
9:00 am - 9:25 am | Laura Kiessling (University of Wisconsin-Madison, USA)
"Peptides for Controlling Cell Fate Decisions" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Alan Saghatelian (Harvard University, USA)
"Discovery and Characterization of sORF-Encoded Peptides" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | Jim Wells (University California San Francisco, USA)
"Engineered Proteins for Detecting PTMs in Biology" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Beth Levine (University of Texas Southwestern Medical Center, USA)
"A Candidate Therapeutic Autophagy-Inducing Peptide" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Joshua Kritzer (Tufts University, USA)
"Cell-Penetrant Bicyclic Peptides that Target SH2 Domains and Tyrosine Phosphatases"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Controlling Macromolecular Assembly and Binding |
| Discussion Leaders: Scott Miller (Yale, USA) and Adam Urbach (Trinity University, USA) |
7:30 pm - 7:55 pm | Sijbren Otto (University of Groningen, Netherlands)
"Emergence of Self-Replicators from Dynamic Molecular Networks Driven by Peptide Self-Assembly" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Marcey Waters (University of North Carolina, Chapel Hill, USA)
"Designing Folded Peptides with Function" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Tanja Kortemme (University California San Francisco, USA)
"Design of Small Molecule Sensor/Actuators and Light-Controlled Protein Machines" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptides as Catalysts and Enzyme Mimetics |
| Discussion Leaders: Robin Offord (Mintaka Foundation for Medical Research, Switzerland) and Anna Rising (Swedish University of Agricultural Sciences, Sweden / Karolinska Institute, Sweden)
|
9:00 am - 9:25 am | David Leigh (Manchester, UK)
"Making the Tiniest Machines" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Scott Miller (Yale, USA)
"Peptide-Based Catalysts and the Search for Efficient Reactions in Complex Molecular Environment" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | Cheryl Woolhead (University of Glasgow, UK)
"Co-Translational Folding of Ribosome Bound Nascent Peptides" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Birte Hocker (Max Planck Institute for Developmental Biology, Tübingen, Germany)
"Design of Proteins from Smaller Fragments" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Giovanna Ghirlanda (Arizona State University, USA)
"Directed Evolution of Protein-Based Hybrid Catalysts for Hydrogen Production"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Design, Discovery and Exploitation of Bioactive Peptides |
| Discussion Leaders: Sam Gellman (University of Wisconsin-Madison, USA) and Jody Mason (University of Essex, UK) |
7:30 pm - 7:55 pm | Glenn King (University of Queensland, Australia)
"Venoms to Drugs: Translating Venom Peptides into Therapeutics for the Treatment of Chronic Pain" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Reto Stocklin (Atheris Laboratories, Switzerland)
"Reverse-Discovery: Drug Discovery and Lead Optimization Tools Inspired by Nature" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Ivan Korendovych (Syracuse University, USA)
"Design of Catalytic Amyloids" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptides as the Basis for Biomaterials Design |
| Discussion Leaders: Alexander Kros (Leiden, Holland) and Jianfeng Cai (University of Southern Florida, USA) |
9:00 am - 9:25 am | Dennis E. Discher (University of Pennsylvania, USA)
"Minimal 'Self' Peptides that Inhibit Phagocytic Clearance" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jeff Hartgerink (Rice, USA)
"Design Criteria for the Collagen Triple Helix" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | Louise Serpell (University of Sussex, UK)
"Amyloidogenic Peptides as a Basis for Functional Materials" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Ken Shea (University of California, Irvine, USA)
"Synthetic Polymer Nanoparticle Receptors for Peptides and Proteins" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | TBA (Young Investigator Speaker Selected from the GRS) |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Approaches to Peptide Chemistry & Bioconjugations |
| Discussion Leaders: Phil Dawson (Scripps Research Institute, USA) and Anna Papini (University of Florence, Italy) |
7:30 pm - 7:55 pm | Mark Howarth (Oxford, UK)
"Spontaneous Isopeptide Bond Formation to Peptides, Applied for Protein Assembly and Cell Capture" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Anna Rising (Swedish University of Agricultural Sciences, Sweden/Karolinksa Institute, Sweden)
"The N-Terminal Domain of Spider Silk Proteins is a pH-Dependent Relay that Can be Harnessed for Heterologous Peptide Production" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Matt Francis (University of California, Berkeley)
"New Chemical Methods for N-Terminal Protein and Peptide Modification" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |