Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Crossing the Barrier from Academics to Industry (and Back) |
| Discussion Leaders: Philip Dawson (The Scripps Research Institute, USA) and Anna Maria Papini (University of Florence, Italy / University of Cergy-Pontoise, France) |
7:40 pm - 8:20 pm | Richard DiMarchi (Indiana University, USA) "Peptide-Based Therapeutics: From Hormones to Polypharmacy" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Peter Kim (Stanford University School of Medicine, USA) "Toward an HIV Vaccine" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptide Discovery: Biological and Chemical Libraries |
| Discussion Leaders: Kit Lam (UC Davis School of Medicine, USA) and John Nuss (Ferring Research Institute, USA) |
9:00 am - 9:20 am | Introduction by Discussion Leader |
9:20 am - 9:45 am | Thomas Kodadek (The Scripps Research Institute, Scripps Florida, USA) "Synthesis and Screening of Large Libraries of Conformationally Restricted Oligomers" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Richard Roberts (University of Southern California, USA) "Directed Evolution of Scanning Unnatural Protease Resistant (SUPR) Peptides for In Vivo Applications" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:35 am | Ratmir Derda (University of Alberta, Canada) "Novel Chemical and Genetics Approaches Chemically-Modified Peptide Libraries" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | James Heath (California Institute of Technology, USA) "Precise Epitope Targeting of Synthetic Macrocyclic Peptides for Biomedical Applications" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Jennifer Cochran (Stanford University, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Peptide Discovery: Where to Look Next |
| Discussion Leaders: Paul Alewood (The University of Queensland, Australia) and Natia Tsomaia (Ipsen, USA) |
7:30 pm - 7:55 pm | Roderich Sussmuth (Technische Universität Berlin, Germany) "Peptide Antibiotics from Pathogenic Microorganisms - Structure, Biosynthesis and Engineering" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Mohamed Marahiel (Philipps-Universität Marburg, Germany) "Insights into the Biosynthesis and Structural Diversity of Bacterial Lasso Peptides" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Richard Lewis (The University of Queensland, Australia) "Unique Defensive and Predatory Envenomation Strategies in Cone Snails" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Posttranslationally Modified Proteins and Conjugates |
| Discussion Leaders: Jeffery Kelly (The Scripps Research Institute, USA) and Geoffrey Wahl (The Salk Institute, USA) |
9:00 am - 9:25 am | Hilal Lashuel (École Polytechnique Fédérale de Lausanne, Switzerland) "Posttranslational Modifications in Neurodegenerative Disease" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Matthew Pratt (University of Southern California, USA) "Investigating the Side-Specific Effects of Posttranslational Modifications with Protein Chemistry" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Christian Becker (University of Vienna, Austria) "Semisynthesis of Posttranslationally Modified Proteins" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Jianmin Gao (Boston College, USA) "Application of Iminoboronate Chemistry in Targeting Biomolecules and Peptide Cyclization" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Jennifer Stockdill (Wayne State University, USA) "Progress Toward a Universal Strategy for the Controlled Folding of Disulfide-Rich Peptides" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Joshua Price (Brigham Young University, USA) "Predictive Structure-Based Guidelines for Identifying Optimal Protein PEGylation Sites" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Peptides in the Immune System |
| Discussion Leaders: Charles Deber (University of Toronto, Canada) and Thomas Nielsen (Novo Nordisk, Denmark) |
7:30 pm - 7:55 pm | Huib Ovaa (The Netherlands Cancer Institute, The Netherlands) "Chemistry of MHC Class I Antigen Presentation" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Dana Ault-Riche (Reflexion Pharmaceuticals, USA) "Immunological Evaluation of Mirror Image Protein Therapeutics" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Michael Chorev (Harvard Medical School, USA) "Glycated CD59: A Novel, Disease Relevant Biomarker in Diabetes" |
9:15 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Critical Analysis of Cell Penetrating
Peptides |
| Discussion Leader: Joel Schneider (National Cancer Institute, NIH, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader: Critical Analysis of Cell Penetrating Peptides |
9:10 am - 9:35 am | Niels Geijsen (Hubrecht Institute, The Netherlands) "iTOP, a Novel Method for the Intracellular Delivery of Native Proteins" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Loren Walensky (Dana-Farber Cancer Institute, USA) "Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptides" |
10:15 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Dehua Pei (The Ohio State University, USA) "Drugging Undruggable Targets with Macrocycles" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Yao-Cheng Leo Li (The Salk Institute for Biological Studies, USA) "ReBiL, a Powerful Platform Technology for Detecting Protein-Protein Interactions and for Identifying Specific Antagonists" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Henry Herce (Technische Universitat Darmstadt, Germany) "Drugs Design and Delivery Using Cell-Penetrating Peptides: A Journey from Molecular Mechanisms to In Vivo Applications" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Peptide Vaccines |
| Discussion Leaders: Peter Kim (Stanford University School of Medicine, USA) and Michael Kay (University of Utah, USA) |
7:30 pm - 7:55 pm | Elisabetta Bianchi (IRBM Science Park S.p.A., Italy) "Strategies for the Development of Effective Peptide Vaccines" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Michael Zwick (The Scripps Research Institute, USA) "Recognition Requirements of Membrane-Proximal 'Linear' Epitopes on HIV-1 gp41" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Regan Anderson (Victoria University of Wellington, New Zealand) "Synthetic Peptide Vaccines Based on Glycolipid-Peptide Conjugates" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jonathan Lai (Albert Einstein College of Medicine, USA) "Engineered Dengue Virus EDIIIs as Immunogen (Vaccine) Candidates" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptides in Epigenetic Regulation |
| Discussion Leaders: Dewey McCafferty (Duke University, USA) and Christian Adam Olsen (University of Copenhagen, Denmark) |
9:00 am - 9:25 am | Champak Chatterjee (University of Washington, USA) "Learning the Language of Histone Modifications with Semisynthetic Tools" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Danica Fujimori (University of California, San Francisco, USA) "Crossttalk Between Chromatin Reader and Eraser Domains in Histone Demethylases" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Beat Fierz (École Polytechnique Fédérale de Lausanne, Switzerland) "Probing the Dynamic Function of Histone PTMs, One Molecule at a Time" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Daniel Baxter (University of Bath, United Kingdom) "Cell-Permeable Helix-Constrained Peptides Inhibit Activator Protein-1 and Reduce Cancer Cell Viability" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Brian Strahl (University of North Carolina, USA) "Using Peptide Arrays to Uncover New Insights into Chromatin Regulation" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Intelligent Materials and Nanoparticles |
| Discussion Leaders: Jennifer Cochran (Stanford University, USA) and James Nowick (University of California, Irvine, USA) |
7:30 pm - 7:55 pm | Nicole Steinmetz (Case Western Reserve University School of Medicine, USA) "Virus Based Therapeutics and Contrast Agents" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Kamaljit Kaur (University of Alberta, Canada) "Microcantilever Arrays Functionalized with a Breast Cancer Targeting Peptide as Detection Platforms for Circulating Tumor Cells" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Annelise Barron (Stanford University, USA) "Deceptively Simple? Peptides that Form Toxin-Antitoxin Complexes" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |