Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Bridging the Gap Between Fundamental and Applied Peptide Science
Discussion Leaders: Jennifer Cochran (Stanford University, USA) and James Nowick (University of California, Irvine, USA)
7:40 pm - 8:20 pm
Peter Dervan (California Institute of Technology, USA)
"Bridging the Gap Between Fundamental and Applied Science in DNA Recognition by Py-Im Polyamides"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
James Wells (University of California, San Francisco, USA)
"Engineering New Peptide Ligases"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stabilized Peptide Therapeutics
Discussion Leaders: Peter Dervan (California Institute of Technology, USA) and Terry Moore (University of Illinois at Chicago, USA)
9:00 am - 9:25 am
Rami Hannoush (Genentech, Inc., USA)
"Challenges and Emerging Approaches in Peptide Drug Discovery"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Dinesh Patel (Protagonist Therapeutics Inc., USA)
"Orally Stable Peptides - Fact or Fiction? Or Discovery and Development of Orally Stable Peptides for Gastro-Intestinal (GI) Diseases"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
James Checco (University of Illinois at Urbana-Champaign, USA)
"Exploring the Signaling of D-Amino Acid-Containing Neuropeptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Jutta Eichler (University of Erlangen-Nuremberg, Germany)
" Mimicking Protein-Protein Interactions Through Peptide-Peptide Interactions: CXCR4 and HIV-1 gp120"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
James Olson (Fred Hutchinson Cancer Research Center, USA)
"The Optide Platform: Designing, Engineering, and Evolving Peptide Drug Candidates"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Natia Tsomaia (Elucidata, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Peptide and Protein Synthesis
Discussion Leaders: James Wells (University of California, San Francisco, USA) and Caroline Proulx (North Carolina State University, USA)
7:30 pm - 7:55 pm
Brad Pentelute (Massachusetts Institute of Technology, USA)
"Automated Flow Peptide Synthesis: Toward Amide Bonds at Nature’s Pace"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Lauren Goodrich (Roche Madison, USA)
"Massively Parallel Synthesis and Screening of Linear Peptides and Macrocycles Using Peptide Microarrays"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
James Tam (Nanyang Technological University, Singapore)
"Ligases: Specific Peptide Staplers"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Peptide Design
Discussion Leaders: Lauren Goodrich (Roche Madison, USA) and Laura Kiessling (Massachusetts Institute of Technology, USA)
9:00 am - 9:25 am
Derek Woolfson (University of Bristol, United Kingdom)
" Peptide Design and Assembly: From Fundamental Principles to Real-Life Applications"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jonathan Lai (Albert Einstein College of Medicine, USA)
" Structure-Based Design of Broad Flavivirus Immunogens"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
He Dong (University of Texas at Arlington, USA)
"Shape-Specific Nanostructured Protein Mimics from De Novo Designed Chimeric Peptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
William Pomerantz (University of Minnesota, USA)
"Design and Synthesis of Highly Fluorinated Biopolymers as 19F MRI Contrast Agents"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Gabriel Rocklin (University of Washington, USA)
"Massively Parallel Investigation of De Novo Miniprotein Folding and Binding"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Amyloids and Peptide Self-Assembly
Discussion Leaders: Derek Woolfson (University of Bristol, United Kingdom) and Aphrodite Kapurniotu (Technical University of Munich, Germany)
7:30 pm - 7:55 pm
Charles Glabe (University of California, Irvine, USA)
"Conformational Polymorphisms of the Amyloid Aβ Peptide in Alzheimer’s Disease"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Wei Qiang (Binghamton University, State University of New York, USA)
"Understanding the Cellular Membrane Disruption Induced by Early-Stage Aggregation of Beta-Amyloid Peptides"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Jevgenij Raskatov (University of California, Santa Cruz, USA)
"Chirality, Alzheimer's Disease and Amyloid Beta"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Engineering
Discussion Leaders: Greg Thurber (University of Michigan, USA) and Marcey Waters (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:25 am
Andreas Plueckthun (University of Zurich, Switzerland)
"Engineering Armadillo Repeat Proteins as Modular Peptide Binders"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Amy Keating (Massachusetts Institute of Technology, USA)
"Exploring the Landscape of Bcl-2 Family Binding Peptides"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
Gaurav Bhardwaj (University of Washington, USA)
"Accurate Computational Design of Heterochiral Constrained Peptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Les Miranda (Amgen, USA)
"Engineering Complimentary Peptide and Antibody Attributes for Efficient Hybridization"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Laura Kiessling (Massachusetts Institute of Technology, USA)
"Molecular Basis of Protein-Carbohydrate Interactions"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Penetration and Drug Delivery
Discussion Leaders: Amy Keating (Massachusetts Institute of Technology, USA) and Joshua Kritzer (Tufts University, USA)
7:30 pm - 7:55 pm
Tomi Sawyer (Merck Research Laboratories, USA)
" Exploring Macrocyclic Peptide Cell Permeability: Screening Tools and Design Rules"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Greg Thurber (University of Michigan, USA)
" Molecular Engineering of Helical Peptides: Designing Intracellular Therapeutics"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Yftah Tal-Gan (University of Nevada, Reno, USA)
"Peptide-Based Tools to Study Cell Signaling in Bacteria"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next-Generation Peptide Therapeutics
Discussion Leaders: Carrie Haskell-Luevano (University of Minnesota, USA) and Ivan Korendovych (Syracuse University, USA)
9:00 am - 9:15 am
Terry Moore (University of Illinois at Chicago, USA)
"Stapled Peptide Inhibitors of the Estrogen Receptor/Coactivator Interaction"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Joshua Kritzer (Tufts University, USA)
"Cell Penetration Profiling Using the Chloroalkane Penetration Assay"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Eun Ji Chung (University of Southern California, USA)
"Targeting Peptides for Nanomedicine"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jacqueline Wilce (Monash University, Australia)
"Rational Development of Bicyclic Peptides Targeting the Grb7 Cancer Target"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
William Schief (The Scripps Research Institute, USA)
"Reductionist Vaccine Design for HIV"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
David Craik (The University of Queensland, Australia)
"Plants as Biofactories for Producing Peptide-Based Pharmaceuticals"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide-Based Materials
Discussion Leaders: Natia Tsomaia (Elucidata, USA) and Richard Roberts (University of Southern California, USA)
7:30 pm - 7:55 pm
Sarah Heilshorn (Stanford University, USA)
"Peptide-Based Materials for Regenerative Medicine Applications"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Vince Conticello (Emory University, USA)
"Peptide and Protein Nanomaterials: The Design Challenge"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Joel Schneider (National Cancer Institute, NIH, USA)
"Racemic Hydrogels from Mirror Image Peptides: Predictions from Pauling and Corey"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure