Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Peptide Engineering and Biology
Discussion Leader: Philip Dawson (Scripps Research, USA)
7:40 pm - 8:20 pm
Lila Gierasch (University of Massachusetts Amherst, USA)
"How Do Hsp70 Molecular Chaperones Recognize Their Client Proteins? The Molecular Origins of 'Promiscuous Selectivity'"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Matthew Tirrell (University of Chicago, USA)
"Peptide-Polymer Conjugates for Therapeutic DNA Delivery"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology of Peptides
Discussion Leader: Joshua Kritzer (Tufts University, USA)
9:00 am - 9:25 am
Marcey Waters (University of North Carolina at Chapel Hill, USA)
"New Strategies for Selective Recognition and Sensing of Post-Translational Modifications in Histone Peptides"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Philip Dawson (Scripps Research, USA)
"Customizing Macromolecules Through Chemical Ligation"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Yftah Tal-Gan (University of Nevada, Reno, USA)
"Utilizing Peptide-Based Tools to Investigate Cell-Cell Communication in Bacteria"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
Carly Schissel (Massachusetts Institute of Technology, USA)
"Machine Learning-Enabled Design of Cell-Penetrating Peptides"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Andrew Buller (University of Wisconsin-Madison, USA)
"Facile Biocatalytic Synthesis of Hydroxylated Non-Canonical Amino Acids"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Wendy Hartsock (Allergan, USA) and Christina Schroeder (Institute for Molecular Bioscience, The University of Queensland, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Materials
Discussion Leaders: Joel Schneider (National Cancer Institute, NIH, USA) and Matthew Tirrell (University of Chicago, USA)
7:30 pm - 7:55 pm
Jean Chmielewski (Purdue University, USA)
"Hierarchical Assembly of Collagen and Coiled Coil Peptide Motifs for Regenerative Medicine"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Lorraine Leon (University of Central Florida, USA)
"Engineering Peptide-Based Complex Coacervates for Therapeutic Delivery"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Eun Ji Chung (University of Southern California, USA)
"Exploiting Peptides to Overcome Barriers in Nanomedicine and Drug Delivery"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neurobiology of Peptides
Discussion Leaders: Matthew Pratt (University of Southern California, USA) and Eileen Kennedy (University of Georgia, USA)
9:00 am - 9:25 am
James Nowick (University of California, Irvine, USA)
"The Supramolecular Chemistry of the Antibiotic Teixobactin"
9:25 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ana Salome Veiga (Instituto de Medicina Molecular, Portugal)
"Anti-HIV-1 Activity and Mode of Action of a Viral-Derived and Proteolysis-Resistant Peptide CXCR4 Antagonist"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Ralf Langen (University of Southern California, USA)
"Targeting Huntingtin Misfolding Using Conformationally Specific Binders: Implications for Therapy and Biomarker Development in Huntington's Disease"
10:55 am - 11:10 am
Discussion
11:10 am - 11:35 am
Thomas Reiner (Memorial Sloan Kettering Cancer Center, USA)
"Neuronal Imaging with Selective Nav1.7 Targeted Peptides"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
K. Johan Rosengren (The University of Queensland, Australia)
"Structure Based Design Targeting the The Neuropeptide Receptor RXFP3"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Peptide Design
Discussion Leader: Carrie Haskell-Luevano (University of Minnesota, USA)
7:30 pm - 7:55 pm
Gaurav Bhardwaj (University of Washington, USA)
"Computational Peptide Design for Targeted Therapeutics"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Armin Geyer (University of Marburg, Germany)
"Enhanced Sampling of Peptide Hairpin Loops to Map out Unusual Folds and Functions"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
E. James Petersson (University of Pennsylvania, USA)
"Experimentally-Constrained Computational Models for Studying Dynamic Proteins and Designing Synthetic Peptides"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Libraries and Lead Discovery
Discussion Leader: Ratmir Derda (University of Alberta, Canada)
9:00 am - 9:25 am
James Van Deventer (Tufts University, USA)
"Laying the Foundation for Performing Drug Discovery on the Yeast Surface"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Steven Millward (University of Texas MD Anderson Cancer Center, USA)
"Directed Evolution of Cyclic Peptides for Inhibition of Autophagy in Ovarian Cancer"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Eline Sijbesma (Eindhoven University of Technology, The Netherlands)
"Stabilization of 14-3-3 Protein-Protein Interactions as a Drug Discovery Strategy"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
Vanessa Carle (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"Phage Display Selection of Peptides that Resist Proteases in the Gastrointestinal Tract"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Hiroaki Suga (University of Tokyo, Japan)
"Displayable Pseudo-Natural Products"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Therapeutics: From Clinical Trials to Market
Discussion Leaders: Ved Srivastava (Intarcia Therapeutics, USA) and Rami Hannoush (Genentech, Inc., USA)
7:30 pm - 7:55 pm
Michael Wagner (Sanofi, Germany)
"Recent Developments and Insights in the Discovery of GLP-1/Glucagon Agonists for the Treatment of Diabetes and Obesity"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Vincent Guerlavais (Aileron Therapeutics, USA)
"Illustrations of Harnessing Intrinsic Properties of Peptides for Therapeutic Benefits with Discovery and Development of Macimorelin and ALRN-6924"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Robert Garbaccio (Merck and Co., Inc., USA)
"Developing Peptides into Drugs for Intracellular Targets: Lessons Learned from p53/MDMX"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Peptide Chemistry, Synthesis and Biosynthesis
Discussion Leader: Marcey Waters (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:25 am
Michelle Chang (University of California, Berkeley, USA)
"Synthetic Biology Approaches to Bioorthogonal Chemistry"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Norman Metanis (The Hebrew University of Jerusalem, Israel)
"Selenium as a Tool for Chemical Synthesis and Folding of Proteins"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Katarzyna Slowinska (California State University, Long Beach, USA)
"Self-Assembled Hybrid Collagen/Cell Penetrating Peptides in Drug Delivery Applications"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Monika Raj (Auburn University, USA)
"Chemical Tools Selective Recognition of Posttranslational Modifications"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Clay Wang (University of Southern California, USA)
"Genome Mining of Fungal Nonribosomal Peptides"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Pathologies and Vaccines
Discussion Leader: Jonathan Lai (Albert Einstein College of Medicine, USA)
7:30 pm - 7:55 pm
Anne De Groot (EpiVax, Inc., USA)
"Immunogenicity of Peptide Drugs and Their Impurities: Taspoglutide Case Study"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Tania Lopez Silva (Rice University, USA)
"Chemical Functionality of Multidomain Peptide Hydrogels Governs Early Host Immune Responses"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Darci Trader (Purdue University, USA)
"Activity-Based Probes with Unnatural Amino Acids to Monitor the Proteasome in Live Cells"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure