Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Exploration of Protein Function
Discussion Leaders: Jane Aldrich (University of Florida, United States) and Anne Conibear (Technische Universität Wien (TU Wien), Austria)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
Tom Muir (Princeton University, United States)
"Janus Particles: On the Role of Molecular Symmetry in Epigenetic Regulation"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Anna Mapp (University of Michigan, United States)
"Writing the Rules for Targeting Dynamic Transcriptional Coactivators"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Chemistry, Synthesis and Biosynthesis
Discussion Leaders: Jennifer Stockdill (Wayne State University, United States) and James Checco (University of Nebraska-Lincoln, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Fernando Albericio (University of KwaZulu-Natal, South Africa)
"New Tools for Solid-Phase Peptide Synthesis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jennifer Heemstra (Washington University in St. Louis, United States)
"Bilingual Biopolymers: Harnessing Dual Information Codes to Control Assembly"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Christina Boville (Aralez Bio, United States)
"Engineering Enzymes for Green Manufacturing of Noncanonical Amino Acids"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Lara Malins (Australian National University, Australia)
"Synthetic Strategies for the Late-Stage Modification of Peptides"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Arunika Ekanayake (University of Alberta, Canada)
"Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Caroline Proulx (North Carolina State University, United States)
"Late-stage azapeptide functionalizations"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Denton (Biotage, United States) and Yftah Tal-Gan (University of Nevada, Reno, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptides in Oncology
Discussion Leaders: Kamaljit Kaur (Chapman University, United States) and Elizabeth Parkinson (Purdue University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Daniel DeOliveira (Mytide Therapeutics, United States)
"Peptide Production Re-invented: Connecting Synthesis, Analysis, Purification and Delivery with a Digital Thread"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Peter Jordan (Lassogen Inc., United States)
"Lasso Peptides as a New Therapeutic Modality"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Eileen Kennedy (University of Georgia, United States)
"Disrupting WASF3-Mediated Metastasis via Constrained Peptides"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Pravin Kaumaya (Ohio State University, United States)
"Peptide B-Cell Epitope Vaccines Synergizes with Combination Checkpoint Blockade Immunotherapy in Solid Tumors"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Peptide Chemistry and Biology
Discussion Leaders: Florence Brunel (Novo Nordisk, United States) and Philip Dawson (Scripps Research, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Meritxell Teixido (Gate2Brain, Spain)
"Gate2Brain Opening the Gate to Cure CNS Diseases"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Carrie Haskell-Luevano (University of Minnesota, United States)
"New Paradigms for GPCR Signaling in Neuroscience"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Jan Pawlas (Polypeptide Group, Sweden)
"Perspectives on Sustainable Peptide Synthesis in the Context of Circular Economy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Late-Breaking Topic
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Nina Hartrampf (University of Zurich, Switzerland)
"Flow-Based Methods in Peptide Chemistry"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jillian Smith-Carpenter (Fairfield University, United States)
"Controlling Reactions on the Surfaces of Peptide Self-Assembled Structures"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Materials
Discussion Leaders: Julie Champion (Georgia Institute of Technology, United States) and Joel Schneider (National Cancer Institute, NIH, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Michael Yu (University of Utah, United States)
"Collagen Hybridizing Peptides and Peptoids: From Protein Folding to Disease Targeting"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Scott Medina (The Pennsylvania State University, United States)
"Building Beyond Biology: Bioinspired Materials with Non-Natural Adaptive Capabilities"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Artemis Stamboulis (University of Birmingham, United Kingdom)
"Development of Antimicrobial Peptide-Based Methods for Biomedical Applications"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andrea Merg (University of California Merced, United States)
"Design and Synthesis of Programmable 2D and 3D Peptide-Based Materials"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology of Peptides
Discussion Leaders: Jutta Eichler (University of Erlangen-Nuremberg, Germany) and David Craik (The University of Queensland, Australia)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Paramjit Arora (New York University, United States)
"Rational Design of Pan-Ras Inhibitors: A Journey with Twists and Turns"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Ashraf Brik (Technion-Israel Institute of Technology, Israel)
"Transition Metals in Peptide and Protein Synthesis"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Olalla Vázquez (University of Marburg, Germany)
"Photoswitchable Peptides as Tools for Light-Controlled Modulation of Protein Complexes"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Late-Breaking Topic
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Cameron Pye (Unnatural Products Inc., United States)
"Aggressively Passive: Achieving Truly Small-Molecule-Like Properties in bRo5 Macrocyclic Peptides"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Juan Del Valle (University of Notre Dame, United States)
"Minimalist Beta-Strand Mimics Targeting Amyloid Assemblies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Peptide Therapeutics: From Clinical Trials to Market
Discussion Leaders: Robert Garbaccio (Merck and Co., Inc., United States) and Lauren Goodrich (Nimble Therapeutics, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Lauren Monovich (Novartis Institutes for Biomedical Research, United States)
"Identification of a PCSK9-LDLR Disruptor Peptide with In Vivo Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Roopa Taranath (Protagonist Therapeutics, United States)
"Discovery and Development of Rusfertide (PTG-300) for the Treatment of Polycythemia Vera (PV)"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Abbas Walji (Merck Research Laboratories, United States)
"Invention of Macrocyclic Peptide PCSK9 Inhibitors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Emel Adaligil (Genentech, Inc., United States)
"mRNA Display Platform for the Discovery of Natural Product-like Macrocyclic Peptides"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Tools, Technologies, and Techniques
Discussion Leaders: Ewa Lis (Koliber Biosciences Inc., United States) and Gaurav Bhardwaj (University of Washington, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Adriaan Bax (National Institutes of Health, United States)
"NMR Search for Hidden Transient Structure in Disordered Polypeptides by Chemical Denaturation"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Stephan Pless (University of Copenhagen, Denmark)
"Semi-Synthesis of Membrane Proteins Using Protein Trans-Splicing"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Lucy Colwell (University of Cambridge, Google Research, United Kingdom)
"Using Machine Learning and Artificial Intelligence for Peptide and Protein Design"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Kendra Frederick (UT Southwestern, United States)
"Sensitivity Enhanced NMR for Structural Biology Inside Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Alison Narayan (University of Michigan, United States)
"Biocatalysis and Complex Molecule Synthesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Cesar de la Fuente (University of Pennsylvania, United States)
"Toward Digital Antibiotic Discovery"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Pushing the Boundaries of Peptide Science
Discussion Leaders: Elizabeth Denton (Biotage, United States), Yftah Tal-Gan (University of Nevada, Reno, United States) and Ved Srivastava (Aktis Oncology, Inc, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:15 pm
Yu-Shan Lin (Tufts University, United States)
"Structure Prediction of Cyclic Peptides Using Molecular Dynamics and Machine Learning"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:05 pm
Alanna Schepartz (University of California, Berkeley, United States)
"Programmed Synthesis of Unusual Peptides and Proteins"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
