Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Pushing the Boundaries of Peptide Science
Discussion Leaders: Paramjit Arora (New York University, United States) and Anna Mapp (University of Michigan, United States)
7:40 pm - 8:20 pm
Samuel Gellman (University of Wisconsin - Madison, United States)
"Probing Informational Properties of Polypeptides with Non-Canonical Modifications"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Donald Hilvert (ETH Zurich, Switzerland)
"High-Throughput Evolution of Biosynthetic Assembly Lines"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovation in Peptide Chemistry
Discussion Leaders: Nina Hartrampf (University of Zurich, Switzerland) and Caroline Proulx (North Carolina State University, United States)
9:00 am - 9:20 am
Jennifer Stockdill (Wayne State University, United States)
"Recent Advances in Greener Peptide Synthesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Talk Selected from GRS
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Ivan Korendovych (Syracuse University, United States)
"Catalytic Amyloids"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Jayanta Chatterjee (Indian Institute of Science, India)
"Understanding the Oral Bioavailability of Macrocyclic Peptides by Masking the Backbone H-Bond Acceptors and Donors"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Talk Selected from GRS
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Beate Koksch (Freie Universitat Berlin, Germany)
"Fluorine in Peptide, Protein and Cell Engineering"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Andrew Roberts (University of Utah, United States)
"Natural Product-Inspired Synthesis of Cyclic Antimicrobial Peptides"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Juan Del Valle (University of Notre Dame, United States) and Florence Brunel (Novo Nordisk, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Therapeutics: From Bench to Clinic
Discussion Leaders: Dave Garman (NoNO Inc, Canada) and Emel Adaligil (Genentech, Inc., United States)
7:30 pm - 7:50 pm
John McGee (Fog Pharmaceuticals, United States)
"Technologies for the Discovery of Helically Constrained Peptide Therapeutics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
William Blackwell III (Aktis Oncology, United States)
"Next-Generation Peptide Therapeutics for the Treatment of Metabolic Diseases"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jim Rotolo (Sapience Therapeutics, Inc., United States)
"Anti-Tumor Activity of ST101, A Peptide Antagonist of the Transcription Factor CCAAT/Enhancer Binding Protein ß"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kaustav Biswas (Merck and Co., United States)
"Engineering Passive Permeability into Macrocyclic Peptides Targeting KRAS"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Peptidomimetics and Alterative Scaffolds
Discussion Leaders: Scott Medina (The Pennsylvania State University, United States) and Seth Horne (University of Pittsburgh, United States)
9:00 am - 9:20 am
Kent Kirshenbaum (New York University, United States)
"(Not) Sorry to Burst your Bubble: Peptoids as Membrane-Active Antivirals"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lesley Chow (Lehigh University, United States)
"3D-Printed Scaffolds with Tunable Growth Factor-Mimetic Peptide Presentation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Thomas Mindt (University of Vienna, Austria)
"Metabolically Stabilized Triazolo-Peptidomimetics for Tumor Targeting"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Chenoweth (University of Pennsylvania, United States)
"Peptide Mimics of the Collagen Triple Helix"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Giuliano (College of Charleston, United States)
"Irregular Secondary Structures as Minimal Preorganizing Units in Peptides"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Samuel Stupp (Northwestern University, United States)
"Peptides in Motion to Create Biomimetic and Bioactive Soft Matter"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tools and Technologies Enabling Peptide Discovery
Discussion Leader: Maria Soloveychik (SyntheX, United States)
7:30 pm - 7:50 pm
Sonia Cantel (IBMM UMR 5247, France)
"Empower Accurate Peptide and Protein Insights with Game-Changing Chemical Probes and Advanced MALDI-MS Strategies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Florian Meier-Rosar (Jena University Hospital, Germany)
"Ion Mobility Separation of Modified Peptides"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Dominik Sarma (Mesa Germany GmbH, Germany)
"A Small Molecule with Big Impact: The Story of a Multifunctional Catch-and-Release Linker for Simple to Complex Peptides"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Louise Walport (Imperial College London and the Francis Crick Institute, United Kingdom)
"Beyond Purified Proteins: Cyclic Peptide Discovery in a More Native Environment"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptides and Delivery
Discussion Leader: Scott Lokey (University of California, Santa Cruz, United States)
9:00 am - 9:20 am
Alex Abramson (Georgia Tech, United States)
"Oral Biologic Drug Delivery using Robotic Microneedle Pills"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kathlynn Brown (SRI International, United States)
"FOX-Three Intracellular Delivery Platform: Peptidic Molecular Guidance Systems for Cell Specific Delivery of Biologics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Allon Hochbaum (University of California, Irvine, United States)
"Sequence Programmable Order-Disorder Transitions in Peptide Self-Assembly"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Muriel Amblard ( French National Centre for Scientific Research (CNRS) - Institute of Biomolecules Max Mousseron, France)
"Harnessing the Potential of Structured Oligomers for Biomolecule and siRNA Intracellular Delivery"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Nathan Gianneschi (Northwestern University, United States)
"Proteomimetic Polymers for Expanding the Druggable Proteome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Wenjing Wang (University of Michigan, United States)
"Optogenetic Sensors and Chemogenetic Tools for Studying Brain Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Naturally and Unnaturally Modified Peptides
Discussion Leader: Annelise Barron (Stanford University, United States)
7:30 pm - 7:50 pm
Tania Lupoli (New York University, United States)
"Unnatural Peptides for Selective Recognition of Hsp70s"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Baptiste Aussedat (Chemitope Glycopeptide, United States)
"Molecular Craftsmanship: Techniques and Advancements in Glycopeptide Synthesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Craig Hutton (University of Melbourne, Australia)
"Traceless C–H Functionalization of Peptides"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Michael Harris (Novo Nordisk, United States)
"Photochemically-Enabled, Post-Translational Production of Therapeutic C-Terminal Amides"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Peptides and Chemical Biology
Discussion Leaders: Michael Bertucci (Lafayette College, United States) and Samuel Gellman (University of Wisconsin - Madison, United States)
9:00 am - 9:20 am
Knud Jensen (University of Copenhagen, Denmark)
"Selective Chemistry on Proteins - His Tag Acylations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
James Checco (University of Nebraska-Lincoln, United States)
"Unraveling the Signaling of Endogenous Cell-Cell Signaling Peptides"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Anna Barnard (Imperial College London, United Kingdom)
"Innovative Approaches to Targeting Protein-Protein Interactions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Richard Payne (The University of Sydney, Australia)
"New Technologies for the Synthesis and Semi-Synthesis of Modified Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ross Cheloha (National Institutes of Health, United States)
"Leveraging Peptide Chemistry and Antibody Recognition to Target Cell Surface Receptors"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Marcos Pires (University of Virginia, United States)
"Permeation of Peptides Across the Outer Membrane Layer of Bacteria"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Expanding Beyond Metathesis
Discussion Leaders: Florence Brunel (Novo Nordisk, United States) and Juan Del Valle (University of Notre Dame, United States)
7:30 pm - 8:15 pm
Scott Miller (Yale University, United States)
"Peptide-Based Catalysis Version[2.0] – Selectivity in High-Complexity Reactions"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Alexander M. Cruickshank Lecture: Helen Blackwell (University of Wisconsin-Madison, United States)
"Chemical Strategies to Intercept and Alter Bacterial Communication Pathways"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
