| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 5:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 - 7:45 pm | Phil Murphy (NIH)
Introduction |
| 7:45 pm - 9:30 pm | KEYNOTE SESSION |
| Chair: Marty Springer (Merck Research Laboratories) |
| 7:45 pm | Keynote address: Robert Lefkowitz (Duke)
Beta-Arrestins: Traffic Cops of Cell Signaling |
| Dhaval Patel (Duke)
Role of beta arrestin-GRK system in lymphocyte chemotaxis |
| George Diaz (Mt. Sinai School of Medicine)
Mutations in the CXCR4 gene cause a combined immunodeficiency disease, WHIM syndrome |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Gi-DEPENDENT AND -INDEPENDENT CHEMOKINE SIGNALING |
| Chair: Kevin Bacon (Bayer) |
| Ann Richmond (Vanderbilt)
Chemokine receptor trafficking: A tale of tails |
| Marcus Thelen (Institute for Research in Biomedicine, Bellinzona)
Chemokine receptor mediated signal transduction |
| Steven Ward (Bath University)
Dissecting Out the Roles of Multiple PI3Ks in Chemokine Signalling and Function |
| Matthias Wymann (University of Fribourg)
Integration of chemokine and GPCR signals by PI3Kγ in allergy and inflammation |
| Jacques Bertoglio (INSERM U461, Chatenay-Malabry)
Rho GTPases in T lymphocyte chemotaxis |
| Ramesh Ganju (Harvard)
Chemokine receptor signaling in physiological and pathological processes |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NOVEL STRUCTURES AND FUNCTIONS |
| Chair: Mette Rosenkilde Roed (Panum Institute) |
| Gerry Graham (Beatson Inst for Cancer Research)
Unravelling novel modes of chemokine function:studies into the biology and biochemistry of ESkine/CTACK/CCL27 |
| Daved Fremont (Washington Univ.)
Promiscuous chemokine sequestration by a herpesvirus decoy receptor |
| Antonio Alcami (Univ of Cambridge)
Novel chemokine binding proteins encoded by viruses |
| Josh Farber (NIAID/NIH)
CXCR3 in the service of host and pathogen |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | REGULATION OF CHEMOKINE ACTION |
| Chair: John Westwick (Novartis) |
| Tracy Handel (University of California at Berkeley)
Oligomerization and CAG binding in chemokine function |
| Amanda Proudfoot (Serono Pharmaceutical Research Inst.)
Novel anti-inflammatory strategy |
| Jeff Shaw (Serono)
Crystallographic studies on the RANTES-Glycosaminoglycan interaction |
| Ronen Alon (Weizmann Inst)
Checks and balances in apical endothelial chemokine functions: destabilizing selectin rolling prior to promoting transendothelial migration |
| Sam Silverstein (College of Physicians and Surgeons, Columbia Univ.)
Neutrophil bactericidal activity in three dimensional fibrin gels |
| Antal Rot (Novartis)
On the DARC side |
| Massimo Locati (University of Milan)
Scavenging of inflammatory CC chemokines by the "silent" receptor D6 |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMOKINES IN HEMATOPOIESIS AND ADAPTIVE IMMUNITY |
| Chair: Alberto Mantovani (Mario Negri Institute) |
| Hal Broxmeyer (Walther Oncology Center, Indiana Univ.)
Involvement of SDF-1 in the survival, homing and mobilization of hematopoietic stem and progenitor cells |
| Antonio Lanzavecchia (Inst. for Research in Biomedicine, Bellinzona)
Chemokines and T cell polarization |
| Martin Lipp (Max-Delbrueck-Center)
Systemic immunoregulatory role of homeostatic chemokine receptors |
| Gwen Randolph (Mt. Sinai School of Medicine)
The chemokines CLL1, CCL17, CCL22 and the chemokine receptor CCR8 are mediators of dendritic cell migration |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHEMOKINE REGULATION OF ADAPTIVE IMMUNITY-II |
| Chair: Sergio Lira (Schering-Plough Research Institiute) |
| Eric Kunkel (Stanford University)
Chemokines and B immunoblast localization to effector tissues |
| Andy Luster (Massachusetts General Hospital)
Chemokines and effector T cell trafficking |
| Barrett Rollins (Dana-Farber Cancer Institute)
Chemokine Function in Adaptive Immunity and Malignancies of the Immune System |
| Kouji Matsushima(Univ of Tokyo)
Role of Chemokines in the Polarization and CTL Induction |
| Reinhold Forster(Hannover Medical School)
CCR7 controls distinct stages of dendritic cell differentiation, mobilization and localization |
| Nathan Karin(Technion)
Plasmid DNA vaccines encoding inflammatory chemokines amplify a pre-existing network that participates in the regulation of T cell-mediated autoimmunity |
| Zach Howard(NCI/NIH)
Identification of auto-antigens with chemotactic activity |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMOKINE ROLES IN IMMUNOLOGICALLY-MEDIATED DISEASE |
| Chair: Joost Oppenheim (NCI) |
| Detlef Schloendorff (University of Munich)
Role of chemokines in kidney diseases |
| Wayne Hancock (Children's Hospital of Philadelphia)
In Vivo Targeting of Chemokine Receptors to Modulate Allograft Rejection |
| Israel Charo (Gladstone Institute)
Chemokines in atherosclerosis, macrophage trafficking, and regulation of the immune response |
| David McDermott (NIAID/NIH)
CX3CR1 and atherosclerosis in man |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHEMOKINE ROLES IN THE CENTRAL NERVOUS SYSTEM AND CANCER |
| Chair: Richard Ransahoff (Case Western Reserve University) |
| Robert Miller (Case Western Reserve University)
The role of chemokines in patterning glial development in the spinal cord |
| Meredith Halks-Miller (Berlex Biosciences)
Chemokine Receptors in Neurodegenerative Diseases |
| Rosalind Segal (Dana-Farber Cancer Institute)
SDF-1α in cerebellar development and disease |
| Albert Zlotnik (Eos Biotech)
Chemokines and cancer |
| Fran Balkwill (Barts and The London, Queen Mary's School of Medicine & Dentistry)
Chemokines and their Receptors in Human Ovarian Cancer |
| Sam Hwang (NCI/NIH)
Chemokine receptors alter metastatic pathways in murine melanoma |
| Ed Roos (Netherlands Cancer Institute)
Chemokine-induced invasion of lymphoma cells depends on synaptotagmin-regulated vesicle fusion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMOKINE-BASED INTERVENTIONS IN DISEASE |
| Chair: Julie DeMartino (Merck Research Laboratories) |
| Richard Horuk (Berlex Biosciences)
Chemokine receptor antagonists |
| Robin Pierson (Vanderbilt University)
CCR5 Blockade Modulates Innate and Adaptive Immunity in Primates |
| Mark Laughlin (Schering-Plough Research Institute)
CCR5 receptor as a target for antiretroviral therapy |
| Greg LaRosa (Millennium)
Successes and challenges in chemokine receptor drug discovery |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
