| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:20 pm | KEYNOTE SESSION |
| 7:30 pm - 8:00 pm | Welcome and Introduction - Barrett Rollins |
| 8:00 pm - 9:00 pm | Siamon Gordon, Sir William Dunn School of Pathology / Oxford University, UK
Keynote Address: "Membrane receptors and macrophage heterogeneity" |
| 9:00 pm - 9:20 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HOW CHEMOKINE RECEPTORS WORK |
| Discussion leader: Philip Murphy, NIH |
| 9:00 am - 9:10 am | Discussion Leader's Introduction |
| 9:10 am - 9:30 am | Tom Schall, ChemoCentryx Inc., Mountain View, CA
"CXCR7: a novel chemokine receptor regulating body patterning, vascularization, angiogenesis, and tumor formation" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Sergio Romagnani, University of Florence, Italy
"CXC chemokines: a link between inflammation and angiogenesis" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Carlos Martinez-A, University of Madrid, Spain
"Chemokine receptors: two do better than one" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | Coffee break / Photo |
| 11:00 am - 11:20 am | Ann Richmond, Vanderbilt University
"The 'in and out' of chemokine receptor mediated chemotaxis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Alberto Mantovani, Mario Negri Institute, Milan, Italy
"Inflammatory CC chemokine scavenging by the decoy receptor D6" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Mette Rosenkilde, Panum Institute, Copenhagen, Denmark
"Molecular mechanisms of chemokine receptor activation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | Short talk: Marc Parmentier, ULB, Brussels, Belgium
"Functional characterization of the ChemR23 ligand, chemerin" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | POSTER SESSION / MENTOR SESSION |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOW CHEMOKINES MAKE CELLS MOVE |
| Discussion Leader: Rick Firtel, UC San Diego |
| 7:30 pm - 7:50 pm | Rick Firtel, UC San Diego
"Finding their way - How cell sense direction" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Carole Parent, NIH
"Chemoattractant signal relay during chemotaxis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Tom Stossel, Harvard Medical School
"A contrarian view of actin remodeling mediating cell movement" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Marie-France Carlier, CNRS, Gif-sur-Yvette, France
"Signaling to actin: a biomimetic actin-based motility assay" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:10 am | HOW CHEMOKINES WORK |
| Discussion Leader: Marco Baggiolini, Università della Swizzera, Italiana, Lugano, Switzerland |
| 9:00 am - 9:10 am | Discussion Leader's Introduction |
| 9:10 am - 9:30 am | Tracy Handel, UC Berkeley
"Interactions of chemokines with glycosaminoglycans" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Amanda Proudfoot, Serono, Pharmaceutical Research Institute, Geneva, Switzerland
"The relevance and significance of glycosaminoglycan binding in chemokine biology" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 12:30 pm | HOW CHEMOKINES INFLUENCE LEUKOCYTE BIOLOGY |
| 10:10 am - 10:30 am | Dan Littman, NYU Medical School
"Chemokine receptors and T cell homeostasis" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Steve Kunkel, University of Michigan
"Novel contribution of chemokines to established immunologic paradigms" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Hal Broxmeyer, Indiana University
"Knowing where to go and live. A role for CD26 and the SDF-1/CXCL12-CXCR4 axis and homing/engraftment of hematopoietic stem cells" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Ronen Alon, Weizmann Institute, Israel
"GPCR signaling under stress: implications for leukocyte interactions with blood vessel walls" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | POSTER SESSION / MENTOR SESSION |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOW CHEMOKINES INFLUENCE INFECTIOUS DISEASE AND VICE VERSA |
| Discussion Leader: Eric Pamer, Memorial Sloan Kettering Cancer Center |
| 7:30 pm - 7:40 pm | Discussion Leader's Introduction |
| 7:40 pm - 8:00 pm | Daved Fremont, Washington University
"Chemokine sequestration by virally encoded decoy receptors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Julio Aliberti, Duke University
"Involvement of CCR5 in Toxoplasma gondii recognition by the innate immune system" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Thais Salazar-Mather, Brown University
"Regulation of innate antiviral inflammatory responses through cytokine/chemokine networks" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | George Diaz, Mt. Sinai School of Medicine
“The end of the tail: CXCR4 truncations and cell trafficking in WHIM syndrome” |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Business Meeting |
| 9:00 am - 12:30 pm | HOW CHEMOKINES AFFECT CANCER |
| Discussion Leader: Barrett Rollins, Harvard Medical School |
| 9:00 am - 9:10 am | Discussion Leader's Introduction |
| 9:10 am - 9:30 am | Ilaria Conti, Dana-Farber Cancer Institute
"Direct effects of CCL2/CCR2 on breast cancer in vivo" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Andrew Kung, Harvard Medical School
"CXCR4 signals in precursor cells and cancers of the central nervous system" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Fran Balkwill, Cancer Research UK
"Why do cancer cells express CXCR4?" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Nellie Polyak, Harvard Medical School
"The role of chemokines in epithelial-stromal cell interactions in breast tumorigenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Sergio Lira, Mt. Sinai School of Medicine
"The chemokine receptor encoded by HHV8 ORF74 triggers an angiogenic program in vivo" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Short talk: Ravindra Uppaluri, Washington University
"Role of chemokine receptor CXCR3 in tumor rejection" |
| 12:15 pm - 12:30 pm | Short talk: Jane Wu, Vanderbilt University
"Slit-Robo signaling in cell migration" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | POSTER SESSION / MENTOR SESSION |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOW CHEMOKINES AFFECT THE IMMUNE RESPONSE |
| Discussion Leader: Harvey Cantor, Harvard Medical School |
| 7:30 pm - 7:40 pm | Discussion Leader's Introduction |
| 7:40 pm - 8:00 pm | Martin Lipp, Max-Delbrück-Center, Berlin, Germany
"Chemokine-driven chronic inflammatory autoimmune responses" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Andrew Luster, Harvard Medical School
"Lipids grease the way for immune cell trafficking" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Wayne Hancock, University of Pennsylvania
"Chemokine-dependent recruitment of T-regulatory cells and allograft tolerance" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Short Talk: Takaharu Okada, UC San Francisco
"Dynamics of antigen-engaged B cell and helper T cell interactions within the lymph node" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HOW CHEMOKINES INFLUENCE INFLAMMATORY DISEASES AND NON-LEUKOCYTE BIOLOGY |
| Discussion Leader: Craig Gerard, Harvard Medical School |
| 9:00 am - 9:10 am | Discussion Leader's Introduction |
| 9:10 am - 9:30 am | Ruth Lehmann, NYU Medical School
"Navigating the embryo: germ cell migration in fly and mouse" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Israel Charo, UC San Francisco
"CCR2-dependent cell trafficking in atheroslcerosis and the immune response" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Robert Strieter, UC Los Angeles
"CXC chemokines: the good, the bad, and the ugly in regulating angiogenesis" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Richard Ransohoff, Cleveland Clinic Foundation
"The raw and the cooked: monocyte and lymphocyte chemokine receptors in lesions of multiple sclerosis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Christopher Power, U. of Calgary
"Chemokines in neuroinflammation: pathogenic or protective roles" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Short talk: Mark Taubman, U Rochester
"Direct interactions between MCP-1 mRNA and the glucocorticoid receptor: a novel mechanism for regulating MCP-1 expression" |
| 12:15 pm - 12:30 pm | Short talk: William Glass, NIH
"CCR5 and the pathogenesis of West Nile Virus infection" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | POSTER SESSION / MENTOR SESSION |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOW TO ANTAGONIZE THE CHEMOKINE SYSTEM |
| Discussion Leader: Martin Springer, Merck, Inc. |
| 7:30 pm - 7:35 pm | Discussion Leader's Introduction |
| 7:35 pm - 7:50 pm | Takashi Kei Kishimoto, Millennium Pharmaceuticals, Inc.
"Mechanistic insights in the biology of CCR2/MCP-1 obtained through the development of anti-CCR2 therapeutic Abs" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Julie DeMartino, Merck, Inc.
"Surprisingly beneficial effects of CCR5 blockade in primate allotransplantation" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Richard Horuk, Berlex Biosciences
"CCR1 antagonists: progress in the clinic" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Tassie Collins, Tularik
"T487: A Selective and Potent Small Molecule Antagonist of CXCR3" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Robert Newton, Incyte
"Real life or created reality: How does CCR2 antagonism compare to the CCR2 knockout?" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
