SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
7:40 pm - 8:00 pm | Discussion Leader: Andrew D. Luster (Massachusetts General Hospital)
"Introduction" |
8:00 pm - 9:00 pm | Ron Germain (NIH)
"Dissecting Immune Cell Navigation Control Using Systems Methods in In Vivo Imaging" |
9:00 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemokine Gradient Sensing |
9:00 am - 9:10 am | Discussion Leader: Ronen Alon (Weizmann Institute of Science)
"Introduction" |
9:10 am - 9:30 am | Michael Sixt (Institute of Science and Technology Austria)
"Leukocyte Navigation in Physiological Chemokine Gradients" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Carol Parent (NCI, National Institutes of Health)
"Live Imaging of Signal Relay During Chemotaxis and Its Relevance to Inflammation and Cancer" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:50 am | Holger Knaut (New York University School of Medicine)
"Generation and Dynamics of Self-Generated SDF1 Signaling Gradient Across a Migrating Tissue" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Susan Schwab (New York University Langone Medical Center)
"Mapping Sphingosine 1-Phosphate Distribution in the Spleen"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Cornelia Halin Winter (ETH Zurich)
"CCL21 Guides Intralymphatic Dendritic Cell Migration in Downstream Direction of the Draining Lymph Node"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Jingsong Xu (University of Illinois)
"Neutrophil Chasing Bacteria Requires a Symmetry-Keeping Mechanism"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Hai Qi (Tsinghua University)
"Total Chemical Synthesis of a Two-Photon-Activable Chemokine and Photon-Guided T Cell Migration In Vivo"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Previews |
| Short Presentations Selected from Posters, Including Brief Discussion |
|
- Gertrud Hjortoe (University of Copenhagen)
"Autocrine CCL19 Blocks Dendritic Cell Migration Against Weak Gradients of CCL21 and May Affect Lymph Node Homing"
- Wei-Jen Tang (The University of Chicago)
"Structures of Human CCL3, CCL4, and CCL18 Reveal the Molecular Basis of Oligomerization and Oligomerization-Mediated Functions"
- Alison Gaylo (University of Rochester Medical Center)
"The Inflamed Dermal Microenvironment Influences Requirements for CD4+ T Cell Interstitial Motility"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemokines in Innate Immune Responses |
7:30 pm - 7:45 pm | Discussion Leader: Phil Murphy (NIAID, National Institutes of Health)
"Introduction" |
7:45 pm - 8:05 pm | G. Scott Worthen (University of Pennsylvania)
"Chemokines and Granulocyte Mobilization" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Wolfgang Weninger (Centenary Institute for Cancer Medicine and Cell Biology)
"Perivascular Macrophages as Regulators of Immune Cell Trafficking and Activation" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Stefan Kaufmann (Max Planck Institute for Infection Biology)
"Control of Neutrophile Influx into the Lung During Tuberculosis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Lai Guan Ng (Singapore Immunology Network)
"Dynamic Imaging of Neutrophil Responses During Immune Complex-Mediated Inflammation"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Chemokines in Adaptive Immunity |
9:00 am - 9:10 am | Discussion Leader: Michael Dee Gunn (Duke University)
"Introduction" |
9:10 am - 9:30 am | Frances Lund (University of Alabama at Birmingham)
"CXCL13 Tunes the Th2 Priming Capacity of DCs and Regulates Th2 Development in LNs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Dan Littman (New York University Langone Medical Center)
"Signals Guiding Effector and Regulatory T Cells to the Intestinal Lamina Propia" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:50 am | Reinhold Forster (Hannover Medical School)
"A Differential Role for CXCL12, CXCL13, and IL17 in Development and Function of Tertiary Lymphoid Tissue" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Adrian Erlebacher (New York University Cancer Institute)
"Epigenetic Regulation of the Decidual Immune Response" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | John Harris (University of Massachusetts Medical School)
"Spatial, Temporal, and Cell-Specific Differences in the Expression of CXCL10 in the Skin Conduct T Cell Activity During the Progression of Vitiligo"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Albert Zlotnik (University of California Irvine)
"The CXCL17/CXCR8 Axis Is a Major Macrophage Recruitment Signal in Mucosal Tissues"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | General Discussion |
12:15 pm - 12:30 pm | Poster Previews |
| Short Presentations Selected from Posters, Including Brief Discussion |
|
- Graeme O'Boyle (University of Sunderland)
"Graft-Versus-Host Disease: Anti-Inflmmatory Efficacy of a CXCR3 Agonist"
- Ji Ming Wang (National Cancer Institute)
"A Chemoattractant Receptor FPR2 Is Critical for Colon Epithelial Homeostasis, Inflammation and Tumorigenesis"
- Amanda Nevins (Medical College of Wisconsin)
"Effect of Structural Alterations on the Antimicrobial Activity of Chemokines"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of Chemokine Function |
7:30 pm - 7:40 pm | Discussion Leader: Marcus Thelen (Institute for Research in Biomedicine)
"Introduction" |
7:40 pm - 8:00 pm | Gerry Graham (University of Glasgow)
"Modelling of the Lymphatic Vasculature by the Atypical Chemokine Receptor ACKR2" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Antal Rot (University of Birmingham)
"Expression and Function of CCRL1 (ACKR4)" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Tracy Handel (University of California, San Diego)
"Structure of a CXCR4: Chemokine Complex and Role of Receptor Dimers" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Mette Rosenkilde (University of Copenhagen)
"Biased and G Protein-Independent Signaling in CCR5 and CCR7"
|
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Poster Preview |
| Short Presentation Selected from Posters, Including Brief Discussion |
|
- James Pease (Imperial College London)
"Biased Agonism at Chemokine Receptors - Challenge or Opportunity for Drug Discovery?"
|
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemokines in Memory Cell Function |
| Discussion Leader: Joshua Farber (NIAID, National Institutes of Health) |
9:00 am - 9:20 am | Joshua Farber (NIAID, National Institutes of Health)
"Regulation of the Differentiation of Human Memory T Cell Subsets" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Akiko Iwasaki (Yale University School of Medicine)
"Chemokine Control of Tissue Resident Memory T Cells" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Thomas Gebhardt (University of Melbourne)
"Skin Immune Surveillance by Tissue-Resident Memory T Cells" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:10 am | Ulrich von Andrian (Harvard Medical School)
"CX3CR1 Expression Distinguishes Three Distinct Subsets of Antigen-Experienced CD8 T Cells" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Michelle McCully (Cardiff University School of Medicine)
"Vitamin D3 Synergizes with cAMP/PKA-Mediated Signaling to Drive Expression of the Skin Homing Receptor CCR8 in Human T Cells" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Gerold Bongers (Icahn School of Medicine at Mount Sinai)
"The HCMV Encoded Chemokine Receptor US28 Modulates Autophagy and Promotes Pancreatitis in Mice"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Krishna Rajarathnam (University of Texas Medical Branch)
"Molecular Bases of How CXCL1-Glycosaminoglycan Interactions Orchestrate In Vivo Neutrophil Trafficking"
|
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:30 pm | Poster Previews |
| Short Presentations Selected from Posters, Including Brief Discussion |
|
- Gudrun Debes (University of Pennsylvania)
"T Cell Egress from the Skin via the Afferent Lymph Determines the Course of Local Tissue Inflammation"
- Aleksandra Ozga (Theodor Kocher Institute, University of Bern)
"Dynamic Control of T Cell Activation by Peptide Affinity"
- Richard Gomer (Texas A&M University)
"The Human Protein DPPIV Is a Neutrophil Chemorepellent"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Chemokines in Inflammatory Diseases in the Clinic |
7:30 pm - 7:40 pm | Discussion Leader: Amanda Proudfoot (Novimmune)
"Introduction" |
7:40 pm - 8:00 pm | Ziad Mallat (Addenbrooke's Hospital)
"B Cell Control of Monocyte Mobilization to the Ischemic Myocardium" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Jose-Carlos Gutierrez-Ramos (Pfizer)
"Therapeutic Control of Diabetic Nephropathy Through CCR2 Inhibition" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Tom Schall (ChemoCentryx)
"Lessons from the Clinic: CCR9 and Other Chemokine Receptor Antagonists" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Yun Sok Lee (University of California San Diego)
"A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System"
|
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Poster Preview |
| Short Presentation Selected from Posters, Including Brief Discussion |
|
- Wanming Zhao (Mount Sinai School of Medicine)
"CX3CR1 Deficiency Delayed Acute Skeletal Muscle Injury Repair by Impairing Macrophage Functions"
|
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemokines in Cancer |
9:00 am - 9:10 am | Discussion Leader: Ann Richmond (Vanderbilt University School of Medicine)
"Introduction" |
9:10 am - 9:30 am | Sharon Evans (Roswell Park Cancer Institute)
"Chemokine Landscape Dictating Tumor Immunity: A Tale of Two Niches" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Mihaela Skobe (Mount Sinai Hospital)
"Role of Chemokines in Lymphatic Metastasis" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:50 am | Naofumi Mukaida (Kanazawa University)
"Crucial Roles of CCL3 in Leukemogenesis and Hematopoiesis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Bodduluri Haribabu (University of Louisville)
"Chemoattractant Regulated Leukocyte Networks in Tumors" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Matthew Albert (Institut Pasteur)
"Dipeptidylpeptidase 4 Diminishes Chemokine-Mediated Leucocyte Trafficking and Limits Naturally Occurring Tumor Immunity"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Raffaella Bonecchi (Humanitas Clinical and Research Center)
"ERK-Dependent Downregulation of the Atypical Chemokine Receptor D6 Drives Tumor Aggressiveness in Kaposi's Sarcoma"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Robert Loewe (Medical University of Vienna)
"Identification of a Chemokine Profile Associated to Melanoma Progression"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Previews |
| Short Presentations Selected from Posters, Including Brief Discussion |
|
- Amnon Peled (Hadassah Hebrew University Hospital)
"The CXCR4 Antagonist BL-8040 Synergizes with the FLT3 Inhibitor AC220 to Induce Apoptosis and Reduce Minimal Residual Disease of AML Cells In Vivo"
- Martine Smit (VU University Amsterdam)
"Targeting the Chemokine Receptor System Using Llama-Derived Antibodies (Nanobodies)"
- Laetitia Comps-Agrar (Genentech)
"CXCL17 Promotes Angiogionesis In Vitro Through Release of PDGF-BB by Monocytes"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemokines in CNS Function and Disease |
7:30 pm - 7:40 pm | Discussion Leader: Sergio Lira (Mount Sinai Hospital)
"Introduction" |
7:40 pm - 8:00 pm | Richard Ransohoff (Cleveland Clinic)
"CXCR2: Surprises from a Conditional Knock-Out" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Robyn Klein (Washington University)
"Control of T Cell Entry at CNS Endothelial Barriers During Neuroinflammation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Marie-Eve Tremblay (Laval University)
"Microglial Chemokine Receptors and Synaptic Refinement" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Nathan Karin (Technioin, Rappaport Faculty of Medicine)
"The Role of Chemokines in Directing the Polarization and Biological Function of Regulatory T Cells"
|
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Poster Preview |
| Short Presentation Selected from Posters, Including Brief Discussion |
|
- Yongting Wang (Shanghai Jiao Tong University)
"Post-Acute CXCL12 Gene Therapy Protects Against Cerebral White Matter Injury in Ischemic Mice by Promoting Oligodendrocyte Progenitor Cell Proliferation, Migration and Remyelination"
|
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |