Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Immune Cell Migration
Discussion Leader: Reinhold Förster (Hannover Medical School, Germany)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
Andrew Luster (Massachusetts General Hospital, USA)
"Chemokines: Three Decades of Insight"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokines in Immune Cell Release and Their Targeting to Non-Lymphoid Organs
Discussion Leader: Bernhard Moser (Cardiff University, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Matteo Iannacone (San Raffaele Scientific Institute, Italy)
"In Vivo Imaging of Antiviral Immune Responses"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Richard Ransohoff (Third Rock Ventures, USA)
"Transcriptome Regulation by Cx3cr1 in Microglial Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Alexander Flugel (University Medical Center Gottingen, Germany)
"The Role of Chemokines in Autoimmune T-Cell Trafficking to the Brain"
10:30 am - 10:40 am
Discussion
10:40 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Philip Murphy (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Cure Strategies for WHIM Syndrome Immunodeficiency"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Paul Proost (Rega Institute, KU Leuven, Belgium)
"Inhibition of Neutrophil-Driven Inflammation with Chemokine-Derived Glycosaminoglycan Binding Peptides"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ariadni Kouzeli (Cardiff University, United Kingdom)
"Identification of CXCL14-Responsive Cells in Healthy Peripheral Tissues"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Johan Duchene (Ludwig Maximilian University of Munich, Germany)
"Atypical Chemokine Receptor 1 Affects the Development of Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Matthew Albert (Genentech, USA)
"Monocyte Homeostasis Is Coordinated by N-Terminal Cyclization of CCR2 Ligands"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Tracy Handel (University of California, San Diego, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Atypical Chemokine Receptors
Discussion Leader: Ronen Alon (The Weizmann Institute of Science, Israel)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gerry Graham (University of Glasgow, United Kingdom)
"A Novel Role for ACKR2 as a Key Regulator of Macrophage Development in Embryogenesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Antal Rot (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
"WHAT4? ACKR4!"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Marcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
"Scavenging Activity of ACKR3 in Health and Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Kathrin Werth (Hannover Medical School, Germany)
"Expression of ACKR4 Defines a Draining Venous Sinus System in the Spleen"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokines and Lipid Mediators in Lymphoid Organ Organization and Function
Discussion Leader: Gudrun Debes (Thomas Jefferson University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Jason Cyster (University of California, San Francisco, USA)
"Oxysterols and Immune Cell Migration"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Susan Schwab (New York University School of Medicine, USA)
"S1P Signaling in the Immune System"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Wolfgang Kastenmüller (University of Würzburg, Germany)
"Chemotaxis-Driven Reorganization of the Dendritic Cell Network upon Viral Infection"
10:30 am - 10:40 am
Discussion
10:40 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ulf Panzer (University Medical Center Hamburg-Eppendorf, Germany)
"Regulation of Th17 and Treg Cell Trafficking in Autoimmune Kidney Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
"Unique Cellular Sources of CXCR3 Ligands Direct Intranodal T Cell Positioning and Interactions Following Viral Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Caroline Sokol (Massachusetts General Hospital, USA)
"CCR8 Controls the Stepwise Migration of Dendritic Cells into the Lymph Node and the Initiation and Polarization of the Allergic Immune Response"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Joshua Farber (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Single-Cell Analysis of CCR6+ Human Th Cells Suggests that Co-Expression of Opposing Pathways Precedes Progressive Th17, Th1 and Th2 Polarization of TEM In Vivo "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
James Pease (Imperial College London, United Kingdom)
"Not All Chemokines Are Created Equal: Probing Ligand Bias at CCR4"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemokines in Effector T Cell Function and Positioning
Discussion Leader: Daniel Legler (University of Konstanz, Switzerland)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Ulrich Von Andrian (Harvard Medical School, USA)
"Mechanisms of Immune Surveillance by Antigen-Experienced T Cell Subsets"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jens Stein (University of Bern, Switzerland)
"Guidance Cues for CD8+ T Cells in Non-Lymphoid Tissues"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Axel Kallies (University of Melbourne, Australia)
"Regulation of Effector Regulatory T Cell Differentiation and Maintenance in Non-Lymphoid Tissues"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Anja Mueller (University of East Anglia, United Kingdom)
"CXCL12 but Not CCL3-Induced Chemotaxis Relies on Rac 1 Activation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Crystal Structure and Therapeutic Targeting of the Chemokine System
Discussion Leader: Brian Volkman (Medical College of Wisconsin, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Tracy Handel (University of California, San Diego, USA)
"What Structure Tells Us About Activation and Inhibition of Chemokine Receptors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Michel Bouvier (Université de Montréal, Canada)
"Functional Selectivity and Regulation of CXCR4 Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:05 am
Thomas Schall (ChemoCentryx, USA)
"Topology Is Destiny: How 'Shape' Shapes Therapeutic Efficacy in the Chemokine System"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Mette Rosenkilde (University of Copenhagen, Denmark)
"Bias in the Chemokine System: How, When, Where and Why?"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Caroline Nguyen (University of Colorado School of Medicine, USA)
"Small Molecule Inhibition of CXCR3 Attenuates Experimental Model of Crohn's Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Natasha Moussouras (Medical College of Wisconsin, USA)
"Structural Studies into Autoinhibition by CCL21"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yoshikazu Takada (UC Davis School of Medicine, USA)
"Chemokines Activate Integrins by Binding to an Allosteric Site (Site 2) of Integrins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Lymphatic and Stromal Cells in Chemokine Biology
Discussion Leader: Antal Rot (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:00 pm
Karl Balabanian (INSERM UMRS-996, Université Paris-Sud, France)
"CXCR4 Desensitization at the Crossroad Between Bone Marrow Hematopoietic and Stromal Cells"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:30 pm
Gwendalyn Randolph (Washington University in St. Louis, USA)
"Immune Cell Crosstalk with Collecting Lymphatic Vessels"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Burkhard Ludewig (Institute of Immunobiology, Kantonsspital St. Gallen, Switzerland)
"Lymphoid Tissue Organizer Cells"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Sabrina Casella (Institute for Research in Biomedicine, Università della Svizzera Italiana, Switzerland)
"The APEX System: An Approach for the Identification of CXCR4 and ACKR3 Interacting Proteins"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chemokines in Myeloid Cell Migration
Discussion Leader: Philip Murphy (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Paul Kubes (University of Calgary, Canada)
"Leukocyte Recruitment in Sterile Injury - Chemokines and a Whole Lot More"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Klaus Ley (La Jolla Institute for Allergy and Immunology, USA)
"Differential Migration Behavior and Chemokine Expression in Four New Subsets of Vascular Macrophages"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Anna Huttenlocher (University of Wisconsin-Madison, USA)
"Imaging Inflammation and Its Resolution"
10:30 am - 10:40 am
Discussion
10:40 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Milka Sarris (University of Cambridge, United Kingdom)
"Signalling Dynamics Governing Neutrophil Guidance in Complex Tissue Environments"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yi Fu (Peking University Health Science Center, China)
"Deficiency of FAM3D, a Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kai Yu (Institute of Immunology, Hannover Medical School, Germany)
"Targeting Regulatory Macrophages to Lymph Nodes for Suppressing Undesired Immune Responses by Forced Overexpression of CCR7"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Acacia Dishman (Medical College of Wisconsin, USA)
"Unfolding the Mysteries of the Metamorphic Chemokine XCL1"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tamara Girbl (Queen Mary University of London, United Kingdom)
"Distinct Vascular Compartmentalisation of Related Chemokines Decisively Supports Neutrophil Diapedesis In Vivo "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sensing of Chemokines
Discussion Leader: Klaus Ley (La Jolla Institute for Allergy and Immunology, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Ronen Alon (The Weizmann Institute of Science, Israel)
"Nuclear Barriers for Leukocyte and Tumor Cell Migration in Chemotactic Fields"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Philippe Bousso (Institut Pasteur, France)
"Propagation and Integration of Immunological Information In Vivo "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Martin Meier-Schellersheim (National Institutes of Health, USA)
"Cellular Sensing of Temporally Changing Chemotactic Stimuli"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Bianca Calì (University of Padova, Italy)
"CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure