Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Chemokines in Rare Diseases
Discussion Leaders: Tracy Handel (University of California, San Diego, United States)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:45 pm
Philip Murphy (National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States)
"Immunology on a WHIM"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Gillian Wilson (University of Glasgow, United Kingdom)
"ACKR2 Control of Macrophage Dynamics"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokine Receptor-Dependent Signal Transduction
Discussion Leader: Bernhard Moser (Cardiff University, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Mario Mellado (Centro Nacional de Biotecnología, CSIC, Spain)
"Receptor Nanoclustering Modulates Chemokine Responses"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Silvano Sozzani (Sapienza University of Rome, Italy)
"CCRL2 Orchestrates Lung Cancer Immune Response"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Sergio Pontejo (National Institute of Allergy and Infectious Diseases, United States)
"Anionic Phospholipids: A New Class of Chemokine-Binding Site Important for both Dying Cell Clearance and Antibiotic Activity by Chemokines"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christoph Scheiermann (University of Geneva, Switzerland)
"Circadian Leukocyte Trafficking in Health and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mette Rosenkilde (University of Copenhagen, Denmark)
"Ligand-Recognition in Viral and Endogenous Chemokine Receptors"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Laura Martínez Muñoz (Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) / Universidad de Sevilla, Spain)
"CXCR4 Organization Dynamics During T Cell Migration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sean Giblin (Imperial College London, United Kingdom)
"CXCL17: an Atypical Chemokine that Negatively Regulates Leukocyte Chemotaxis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Ann Richmond (Vanderbilt University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structures and In Silico Modeling
Discussion Leader: Mette Rosenkilde (University of Copenhagen, Denmark)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Tracy Handel (University of California, San Diego, United States)
"Atypical Structure and Activation of an Atypical Chemokine Receptor"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Thomas Schall (ChemoCentryx, United States)
"‘Overnight Success’: First Phase 3 Pivotal Trial Proof that Inhibition of a Single Chemoattractant Receptor Provides a Novel Treatment in a Human Inflammatory/Autoimmune Disease"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Acacia Dishman (Medical College of Wisconsin, United States)
"Evolution of Metamorphic Protein Folding in the Chemokine XCL1"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Brian Volkman (Medical College of Wisconsin, United States)
"Conformational Selection in ACKR3 Activation and Inhibition"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokine-Mediated Cell Migration
Discussion Leader: Daniel Legler (University of Konstanz, Switzerland)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Philippe Bousso (Institut Pasteur, France)
"Decoding the Mode of Action of CAR T Cells In Vivo "
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Holger Knaut (New York University School of Medicine, United States)
"Robust Migration through Chemokine Buffering"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Katharina Glaser (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Combinatorial Genetic Depletion of GPCR Kinase (GRK) Family Members Identifies Pleiotropic and Cell Type-Specific Roles of GRKs in Leukocytes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Abigail Roberts (University of Leeds, United Kingdom)
"Glycosaminoglycans in the Extracellular Matrix Slow Chemokine Diffusion and Cause Clustering"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Carole Parent (University of Michigan, United States)
"Leukotriene B4 Signaling during NET Release and Chemotaxis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tal Arnon (University of Oxford, United Kingdom)
"Humoral Immunity in the Lung"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Giulia D'Uonnolo (Luxembourg Institute of Health, Luxembourg)
"The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jaisel Cervantes (The University of Texas at El Paso, United States)
"CCR7 Differentially Regulates Migration of Effector T cells to the Bone Marrow to Limit the Secondary Immune Response"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Atypical Chemokine Receptors
Discussion Leader: Reinhold Förster (Hannover Medical School, Germany)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Martyna Szpakowska (Luxembourg Institute of Health, Luxembourg)
"Modulating the Scavenging Function of Atypical Chemokine Receptors for Improved Cancer Therapy"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Daniel Legler (University of Konstanz, Switzerland)
"Typical and Atypical Signaling by the Chemokines CCL19 and CCL21"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Serena Melgrati (Institute for Research in Biomedicine, Bellinzona, Switzerland)
"Characterization of GPR182: a Broad Chemokine Scavenger"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Ralf Stumm (Jena University Hospital, Germany)
"ACKR3 Functions in the CNS"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokines in Cancer
Discussion Leader: Thomas Schall (ChemoCentryx, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Aleksandra Ozga (Department of Biosystems Science and Engineering, ETHZ, Switzerland)
"The CXCR3 Chemokine System and T Cell Responses to Chronic Infection and Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Burkhard Ludewig (Kantonsspital St. Gallen, Switzerland)
"Chemokine-Producing Fibroblast Shape the Tumor Microenvironment"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Raffaella Bonecchi (Humanitas University Humanitas Research Hospital, Italy)
"Role of the Atypical Chemokine Receptor ACKR2 in the Immune Response to Tumors"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Johan Duchene (Ludwig Maximilian University of Munich, Germany)
"Activated Neutrophil Phenotype in Mice with Erythroid-specific ACKR1-Deficiency due to an African FyB(ES)-like Polymorphism"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Adit Ben-Baruch (Tel Aviv University, Israel)
"The PD-L1-Chemokine Connection in Breast Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ann Richmond (Vanderbilt University, United States)
"CXCR2 Modulates Gene Expression in Melanocytes with BRAF/PTEN and NRAS/INK4a Alterations to Mediate Melanoma Tumor Formation and Growth"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Tanja Hartmann (Medical Center University Freiburg, Department of Internal Medicine I, Germany)
"Kindlin-3 Limits CXCR5 Responsiveness in B Cell Homeostasis and Malignancy but Promotes Tumor Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Marco Emilio Bianchi (Universita' Vita-Salute San Raffaele , Italy)
"CXCR4 Engagement with CXCL12 Triggers CD47 Internalization and Antitumor Immunization in a Mouse Model of Mesothelioma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chemokines in Pathologies
Discussion Leader: Antal Rot (Queen Mary University of London, United Kingdom)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
"Interplay of Type I and II IFNs for the Organisation of T Cell Position, Differentiation, and Function"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Jens Stein (University of Fribourg, Switzerland)
"Chemokine Control of T Cell Activation and Differentation"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Paul Proost (Rega Institute, KU Leuven, Belgium)
"Proteoforms of Chemokines with Modified Activities in Infection and Sterile Inflammation"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Berislav Bosnjak (Hannover Medical School, Germany)
"Identification of Novel Receptors Enabling MCK2-Mediated MCMV Infection of Macrophages and Virus Dissemination to the Salivary Gland"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chemokines in Health and Disease
Discussion Leader: Philip Murphy (National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Rosa Barreira da Silva (Genentech Inc., United States)
"Targeting Post-Translational Modifications of Chemokines as an Immunotherapy for Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Davide Robbiani (Institute for Research in Biomedicine, Switzerland)
"Chemokines and COVID-19"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Howard Zhang (National Institutes of Health, United States)
"Leukocyte Trafficking in Severe COVID-19"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Deborah Fowell (Cornell University, United States)
"Spatiotemporal Transcriptional Regulation of CXCR3 Following Inflamed Tissue Entry Optimizes Th1 Function"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Reinhold Förster (Hannover Medical School, Germany)
"Multiple Facets of ACKR4 in Organizing Lymphoid Compartments"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michel Bouvier (Université de Montréal, Canada)
"Oligomeric Assembly and Functional Selectivity of Chemokine Receptors"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Valentina Cecchinato (Institute for Research in Biomedicine, Università della Svizzera italiana, Switzerland)
"Deciphering the Mechanisms Regulating the CXCL12/HMGB1 Heterocomplex Activity in Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Oliver Hartley (Orion Biotechnology, Switzerland)
"Discovery of a Chemokine Analog CCR2 Antagonist with Best-in-Class Potency"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Chemokines in Immune Responses
Discussion Leader: Ronen Alon (Weizmann Institute of Science, Israel)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
Eugene Butcher (Stanford University, United States)
"Chemokines and Novel Chemoattractants in Establishment of the Mucosal Immune System"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Sussan Nourshargh (Queen Mary University of London, United Kingdom)
"Dysregulated Generation and Localisation of Chemokines Drives Aberrant Neutrophil Trafficking"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Antal Rot (Queen Mary University of London, United Kingdom)
"Chemokine Interactions with Erythroid Cells: DARC, Darker and Pitch-Dark"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure