SATURDAY |
1:30 pm - 4:30 pm | Arrival and Check-in |
3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:15 pm - 4:00 pm | Highlights: Three sides of CXCR3 in Immunity and Inflammation |
| Discussion Leader: Sergio Lira |
3:15 pm - 3:25 pm | Joanna Groom (Massachusetts General Hospital)
"A role for CXCR3 receptor-ligand interactions during CD4+ T helper 1 differentiation"
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3:25 pm - 3:30 pm | Discussion |
3:30 pm - 3:40 pm | Graeme O'Boyle (Newcastle University)
"A CXCR3 agonist prevents human T cell migration in a humanized model of arthritic inflammation"
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3:40 pm - 3:45 pm | Discussion |
3:45 pm - 3:55 pm | Ye Oo (University of Birmingham)
"CXCR3 dependent recruitment and CCR6 mediated positioning of Th17 cells in the inflamed human liver"
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3:55 pm - 4:00 pm | Discussion |
4:00 pm - 5:30 pm | Poster Session I |
| Antal Rot, Albert Zlotnik and Barrett Rollins |
5:30 pm - 6:30 pm | Chemokine Biochemistry and Cell Biology |
| Discussion Leader: Amanda Proudfoot |
5:30 pm - 5:40 pm | Jamie Wieting (Medical College of Wisconsin)
"Structural and Functional Studies of Lymphotactin (XCL1) and XCL2"
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5:40 pm - 5:45 pm | Discussion |
5:45 pm - 5:55 pm | Gemma White (University of Oxford)
"Investigating the function of the CX3C chemokine fractalkine as a key mediator of human monocyte survival"
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5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Thinh Nguyen-Duc (Memorial Sloan Kettering Cancer Center)
"Development of a photo-activation system for the studying of SDF1-CXCR4 signaling dynamics in T-cell"
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6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Emma Pepperell (University of Oxford)
"A novel method to track human CD133+ haemopoietic stem/progenitor cell chemoktaxis towards CXCL12"
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6:25 pm - 6:30 pm | Discussion |
6:30 pm - 7:30 pm | Atypical Chemokine Receptors |
| Discussion Leader: Antal Rot |
6:30 pm - 6:40 pm | Darren Asquith (University of Glasgow)
"The atypical chemokine receptor CCX-CKR regulates CCL19 and CCL21, and fine-tunes immune responses in the lung"
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6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Igor Novitzky-Basso (University of Birmingham)
"The development of humanized DARC FYB(ES) transgenic mouse"
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6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Benedetta Savino (Istituto Clinico Humanitas)
"Control of Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6"
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7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Luise Humpert (IRB)
"Molecular mechanisms of CXCR7 sorting and potential signaling properties"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:00 am | Chemokines in Host Defense and Infection |
| Discussion Leader: Albert Zlotnik |
9:00 am - 9:10 am | Clive McKimmie (University of Glasgow)
"From bite to brain: chemokine-mediated innate immune responses to mosquito bites and their viruses"
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9:10 am - 9:15 am | Discussion |
9:15 am - 9:25 am | Susana Bardina (Mount Sinai School of Medicine)
"Regulation of West Nile virus Pathogenesis by Chemokine Receptor CCR7 in mice"
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9:25 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Jennifer Goldblatt (Imperial College)
"Streptococcus pyogenes and CXCL8: C-terminal cleavage and signaling interruption"
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9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Amanda Burkhardt (University of California, Irvine)
"CXCL17: A Novel Mucosal Chemokine With Antimicrobial Activity"
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9:55 am - 10:00 am | Discussion |
10:00 am - 11:00 am | Chemokines in Cancer and Chronic Inflammation |
| Discussion Leader: Barrett Rollins |
10:00 am - 10:10 am | Xuguang Chen (Dana Farber Cancer Institute)
"Distinct roles for CCL2/MCP-1 and CCR2 in mammary cancer development and tumor neovascularization"
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10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Sebastian Hofbauer (University Clinic Salzburg)
"Alterations in CXCR4 and beta1 integrin induced Rho/Rac signaling and its impact on motility, homing, and survival of chronic lymphocytic leukemia cells"
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10:25 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Johan Duchene (Delbruck-Centrum)
"CXCL5 modulates foam cell formation in atherosclerosis"
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10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | Wuzhuo Wan (National Institutes of Health)
"Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient Mice"
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10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session II |
| Amanda Proudfoot, Sergio Lira and Antal Rot |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Chemokines in Health and Disease |
| Discussion Leader: Uli von Andrian |
1:30 pm - 1:40 pm | Timm Schlegelmilch (EMBL)
"Towards understanding neuron-microglia communication in the living brain"
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1:40 pm - 1:45 pm | Discussion |
1:45 pm - 1:55 pm | Silke Muehlstedt (Max Delbruck-Centrum)
"The dark side of cardiomyocyte-specific CXCL12/SDF-1"
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1:55 pm - 2:00 pm | Discussion |
2:00 pm - 2:10 pm | Moira Francois (Imperial College)
"Niche specific chemokine receptor expression of mesenchymal stromal cells"
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2:10 pm - 2:15 pm | Discussion |
2:15 pm - 2:25 pm | Corinna Weber (Karl-Franzens University Graz)
"Proteomic exploration of downstream signaling induced by CXCL8 binding to lung endothelial cells"
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2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |