| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Chemokine Requirements During Immune Activation |
| Discussion Leader: Sergio Lira (Mount Sinai School of Medicine) |
| 3:45 pm - 3:55 pm | Lehn Weaver (The Children's Hospital of Philadelphia)
"CCR2+ Inflammatory Monocytes Bypass Toll-Like Receptor 9 Tolerance During CpG-Induced Cytokine Storm" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 4:10 pm | Aleksandra Ozga (Theodor Kocher Institute, University of Bern)
"Dynamic Control of T Cell Activation by Peptide Affinity" |
| 4:10 pm - 4:15 pm | Discussion |
| 4:15 pm - 4:25 pm | Marieke Pingen (University of Glasgow)
"Chemokine-Mediated Innate Immune Response to Mosquito Bites Facilitates the Transmission and Dissemination of Mosquito-Borne Viruses" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 8:30 pm | Chemokine Control of Inflammation |
| Discussion Leader: Gerry Graham (University of Glasgow) |
| 7:30 pm - 7:40 pm | Seddon Thomas (NIEHS/ NIH)
"Epithelial and Dendritic Cell Expression of the Adaptor Protein MyD88 Trigger Distinct Types of Allergic Inflammatory Responses in the Lung" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Kave Shams (University of Glasgow, Chemokine Research Group)
"Psoriasis-Associated MicroRNAs and Tensile Cell Stress Modulate Expression of the Atypical Chemokine-Scavenging Receptor ACKR2" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Jiqing Sai (Vanderbilt University)
"Altered Leukocyte Infiltration Inhibits Mammary Cancer Growth and Metastasis in PI3K Inhibited Mice" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Alison Gaylo (University of Rochester Medical Center)
"The Inflamed Dermal Microenvironment Influences Requirements for CD4+ T Cell Interstitial Motility"
|
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:30 pm | Chemokine Function During Infection |
| Discussion Leader: Antal Rot (University of York) |
| 8:30 pm - 8:40 pm | Maud Deruaz (Massachusetts General Hospital)
"Role of Immune Cell Trafficking in HIV Transmission Following Intravaginal Exposure" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Susana Bardina (Ichan School of Medicine at Mount Sinai)
"Differential Roles of Chemokines CCL2 and CCL7 During West Nile Virus Infection" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Nils Lannes (University of Fribourg)
"Japanese Encephalitis Virus Modulates the Expression of Chemokine Receptors on HLA-DR Expressing Human Microglial cells" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Elizabeth Sorensen (Massachusetts General Hospital)
"Imaging the Role of CXCR3 and Its Ligands in the Interaction of T Cells with the Brain Vasculature in a Murine Model of Cerebral Malaria" |
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:45 am | Chemokine Biochemistry and Interactions |
| Discussion Leader: Amanda Proudfoot (Chemokine Biologist, Freelance Consultant) |
| 9:00 am - 9:10 am | Catriona Barker (Newcastle University)
"CCL2: The Immunoregulatory Potential of Oxidative Stress" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Amanda Nevins (Medical College of Wisconsin)
"Effect of Structural Alterations on the Antimicrobial Activity of Chemokines" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Douglas Dyer (University of California, San Diego)
"The Role of Glycosaminoglycan-Binding and Oligomerisation of Chemokines in Their Presentation on, and Modification of, Cell-Surface Glycosaminoglycans" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Development of Novel Mice for Chemokine Research |
| Discussion Leader: Amanda Proudfoot (Chemokine Biologist, Freelance Consultant) |
| 9:45 am - 9:55 am | Laura Medina-Ruiz (University of Glasgow)
"Generation of a Reporter Mouse Strain for the Inflammatory CC Chemokine Receptors" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Fabian Schuette (University of Glasgow)
"Generation of Reversible iCCR Null Mice" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 11:00 am | Development of Chemokine-Based Therapeutics |
| Discussion Leader: Phil Murphy (NIAID/NIH) |
| 10:15 am - 10:25 am | Graeme O'Boyle (University of Sunderland)
"Graft-Versus-Host Disease: Anti-Inflmmatory Efficacy of a CXCR3 Agonist" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Djevdet Ahmet (University of Bradford)
"Targeting the Formylpeptide Receptor-1 for Treatment of Glioma" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Pauline Bonvin (NovImmune S.A.)
"Understanding the Properties of Antibodies Targeting CXCL10 in Order to Inhibit the Chemokine's In Vivo Activity" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Panel Discussion: Exploring the Next Step |
| Panelists:
- Laurie Dempsey (Nature Immunology)
- Jean Lim (Mount Sinai)
- Tom Schall (Chemocentryx)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
