Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Remodeling Chromatin Structure
Discussion Leader: Ali Shilatifard (Northwestern University, United States)
7:40 pm - 8:00 pm
Craig Peterson (University of Massachusetts Medical School, United States)
"Chromatin Dynamics and Transcriptional Homeostasis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Robert Porter (University of Michigan Medical School, United States)
"A Neuron-Specific Histone Demethylase Complex Fine Tunes Neurodevelopment"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Shiv Grewal (National Cancer Institute, NIH, United States)
"Mechanisms Underlying Heterochromatin Formation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Petra Hajkova (MRC London Institute of Medical Sciences, United Kingdom)
"Stability and Dynamics of Epigenetic Modifications"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Sebastian Deindl (Uppsala University, Sweden)
"Direct Observation of DNA Buffering on the Nucleosome During Chromatin Remodeling Under Single-Turnover Conditions"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Assembly, Replication and Repair
Discussion Leader: Peter Becker (Ludwig-Maximilians-University of Munich, Germany)
9:00 am - 9:20 am
Thomas Jenuwein (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"De Novo Heterochromatin Formation in the Mouse Genome"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Danny Reinberg (New York University School of Medicine/HHMI, United States)
"Chromatin Domains and Epigenetic Inheritance"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Claire Rougeulle (Université Paris Cité, France)
"Regulation of X Chromosome Inactivation in Humans"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Sundeep Kalantry (University of Michigan, United States)
"Activation of Xist by an Evolutionarily Conserved Function of KDM5C Demethylase"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Caroline Dean (John Innes Centre, United Kingdom)
"Molecular Basis of Epigenetic Switching"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Steven Jacobsen (University of California, Los Angeles, United States)
"Mechanisms of Gene Silencing Downstream of Methylation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
General Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Claire Rougeulle (Université Paris Cité, France) and Petra Hajkova (MRC London Institute of Medical Sciences, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Histone and RNA Modifications
Discussion Leader: Wendy Bickmore (MRC Human Genetics Unit, United Kingdom)
6:00 pm - 6:20 pm
Tony Kouzarides (University of Cambridge, United Kingdom)
"Modifications of RNA and Their Role in Cancer"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Alessandro Gardini (The Wistar Institute, United States)
"A Phosphatase Module of the Integrator Complex Regulates Pausing and Elongation"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Irene Cantone (University of Naples Federico II, Italy)
"Human X Chromosome Reactivation: Structural and Molecular Dynamics During Human Pluripotent Reprogramming"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Andreas Ladurner (Ludwig-Maximilians-University of Munich (LMU Munich), Germany)
"DNA-Damage Induced Regulation of Rapid Chromatin Remodeling by Nuclear PARPs"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
William Greenleaf (Stanford University, United States)
"Exploring the Physical Genome"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosomes and Genome Architecture
Discussion Leader: Andreas Ladurner (Ludwig-Maximilians-University of Munich (LMU Munich), Germany)
9:00 am - 9:20 am
Carl Wu (Johns Hopkins University, United States)
"Dynamics of Transcription and Chromatin Remodeling Proteins at Single Molecule Level"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Wendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"Enhancer Function in the Context of the 3D Genome"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Karolin Luger (University of Colorado Boulder, United States)
"Unfinished Business: Nucleosome Remodeling and Assembly"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Yidan Sun (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"MSL Complex Ensures Biallelic Gene Expression in Mammals"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Jumana AlHaj Abed (Harvard Medical School, United States)
"Investigating How Homolog Organization Shapes Regulatory Programs Using Genomic and Single-Cell Approaches"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Dirk Schübeler (Friedrich MIescher Institute for Biomedical Research, Switzerland)
"Transcription Factors as Sensors and Modifiers of Chromatin"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Vijay Ramani (Gladstone Institutes / UCSF, United States)
"Single-Fiber Nucleosome Density Shapes Regulation by a Chromatin Remodeler"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Peter Becker (Ludwig-Maximilians-University of Munich, Germany)
"Snapshots of Divergent Evolution Towards Sex Chromosome-Specific Gene Regulation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin, Metabolism and Physiology
Discussion Leaders: Karolin Luger (University of Colorado Boulder, United States)
6:00 pm - 6:20 pm
Raul Mostoslavsky (Massachusetts General Hospital and Harvard Medical School, United States)
"From Transcriptional Pausing to Metabolism and Cancer: Lessons From SIRT6"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Shelley Berger (University of Pennsylvania, United States)
"Acetylation and Metabolic Control"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Raffaella Santoro (University of Zurich, Switzerland)
"Genome Organization in and Around the Nucleolus"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Edith Heard (EMBL European Molecular Biology Laboratory, Germany)
"Mechanisms of Gene Silencing and Dosage Regulation During X-Chromosome Inactivation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Jamie Hackett (European Molecular Biology Laboratory (EMBL), Italy)
"Quantitative Impact of Chromatin Modifications on Transcription"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Deniz Goekbuget (University of California San Francisco, United States)
"Phasic Transcriptional Repression Protects Genome Integrity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reprogramming and Regeneration
Discussion Leader: Joanna Wysocka (Stanford University School of Medicine, United States)
9:00 am - 9:20 am
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"Mammalian Epigenetic Inheritance"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Michelle Percharde (MRC London Institute of Medical Sciences, United Kingdom)
"Nucleolar Chromatin-Based Control of Cell Fate in Early Development"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Yi Zhang (Harvard Medical School, United States)
"Distinct Dynamics and Function of H2AK119ub1 and H2K27me3 in Mouse Preimplantation Embryos"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Emma Chory (Massachusetts Insitute of Technology, United States)
"Nucleosome Turnover Regulates Epigenetic Modifications of the Genome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Bradley Cairns (University of Utah, United States)
"Mechanisms of Chromatin Remodeling"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Amanda Fisher (MRC London Institute of Medical Sciences, United Kingdom)
"Epigenetics and Inheritance"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Alexander Meissner (Max Planck Institute for Molecular Genetics, Germany)
"Mechanisms of Epigenetic Regulation in Early Development"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin and Disease Mechanisms
Discussion Leaders: Craig Peterson (University of Massachusetts Medical School, United States)
6:00 pm - 6:20 pm
Sharon Dent (University of Texas MD Anderson Cancer Center, United States)
"SAGA Functions in Development and Disease"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Ali Shilatifard (Northwestern University, United States)
"Principles of Epigenetics and Chromatin in Development and Human Disease"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Nicholas Prescott (Memorial Sloan Kettering Cancer Center, United States)
"Chromatin Assembly Facilitates Transcription of the Hepatitis B Virus Oncogene HBX"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Joanna Wysocka (Stanford University School of Medicine, United States)
"Long-Range Gene Regulations by Enhancers"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Neil Brockdorff (University of Oxford, United Kingdom)
"Dynamic Behaviour of Xist RNA in X Chromosome Inactivation"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chromatin Biophysics
Discussion Leader: Geeta Narlikar (University of California, San Francisco, United States)
9:00 am - 9:20 am
Xavier Darzacq (University of California, Berkeley, United States)
"Dynamics and Kinetics of Chromatin Organization and Transcription Regulation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Ibrahim Cisse (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Super Resolution Imaging of Transcription in Live Mammalian Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Michael Rosen (University of Texas Southwestern Medical Center, United States)
"Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Stefan Niekamp (Massachusetts General Hospital & Harvard Medical School, United States)
"Phase Separation of Polycomb-Repressive Complex 1 Is Promoted by a Chromatin Scaffold"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Leonid Mirny (Massachusetts Institute of Technology, United States)
"Loop Extrusion and Gene Regulation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Daniel Jost (CNRS - ENS Lyon - LBMC, France)
"Spatial Organization of Chromosomes Drives the Liquid- or Gel-like Dynamical Behavior of Chromatin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Laura Hsieh (UCSF, United States)
"A Hexasome Is the Preferred Substrate for the INO80 Chromatin Remodeling Complex, Allowing Versatility of Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Coral Zhou (University of California, Berkeley, United States)
"Mechanisms of Mitotic Chromosome Scaling During Xenopus Laevis Embryogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transcription and Post-Transcriptional Events
Discussion Leader: Ibrahim Cisse (Max Planck Institute of Immunobiology and Epigenetics, Germany)
6:00 pm - 6:20 pm
Nicola Iovino (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Establishment of Heterochromatin in the Early Embryo"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
David Tremethick (The Australian National University, Australia)
"An Evolutionary Advanced Mechanism of Gene Expression Control: the Regulation of SWI/SNF by the Histone Variant H2A.B"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
Hiroshi Kimura (Tokyo Institute of Technology, Japan)
"Histone Modification Dynamics During Transcription Activation in Living Cells and Embryos"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Lucas Farnung (Harvard Medical School, United States)
"Structural Basis of Nucleosome Retention During Transcription Elongation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Jerry Workman (Stowers Institute for Medical Research, United States)
"Nutrient Signaling Through Histone Modifications"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure