SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | FUNCTIONAL ORGANIZATION OF CHROMOSOMES |
| Discussion Leader: Sue Lovett (Brandeis University) |
7:40 pm - 8:20 pm | David Sherratt (University of Oxford)
"Watching molecules one by one in DNA replication and chromosome segregation" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Susan Gasser (Friendrich Miescher Institute for Biomedical Reseach)
"The biology of DNA dynamics: how remodelers facilitate repair" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VIEWS OF CHROMOSOMES AND CHROMOSOMAL PROTEINS |
| Discussion Leader: David Sherratt (Oxford University) |
9:00 am - 9:20 am | James Berger (University of California-Berkeley)
"Molecular mechanisms for initiating DNA replication" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Nancy Kleckner (Harvard University) "The living E.coli nucleoid: structure, mechanics and short-time-scale dynamics" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Xiaowei Zhuang (Harvard University)
"Single-molecule studies of chromosome dynamics and remodeling" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:20 am | Maria Spies (University of Illinois-Urbana Champaign)
"Sorting posttranslationally modified DNA repair machines in single-molecule studies" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kiyoshi Muzuuichi (NIDDK)
"Visualizing the assembly and disassembly of segregation machines" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kazuhiro Maeshima (National Institute of Genetics, Mishima) "Mitotic chromosome structure: irregular folding of nucleosome fibers without the 30-nm chromatin fiber" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Thomas Maresca (University of Massachusetts, Amherst) "Regulation of kinetochore-microtubule attachment by mitotic forces" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CHROMOSOME INTERACTIONS |
| Discussion Leader: James Berger (University of California-Berkeley) |
7:30 pm - 7:50 pm | Jennifer Fung (UCSF)
"Kinetics of chromosome synapsis during meiosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Aaron Straight (Stanford University)
"In vitro centromere and kinetochore assembly on reconstituted centromeric chromatin" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Abby Dernburg (University of California-Berkeley)
"Dynamics of homolog interactions during meiosis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Jorge Schvartzman (Centro de Investigaciones Biologicas, CSIC) "Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Kingsley Boateng (NIDDK) "Novel early homolog pairing independent of meiotic double-strand breaks and homologous recombination during mammalian meiosis" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENOME STRUCTURE AND EVOLUTION |
| Discussion Leader: Abby Dernburg (University of California-Berkeley) |
9:00 am - 9:20 am | David Pellman (Harvard Medical School)
"Chromosome breaks from errors in mitosis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ting Wu (Harvard Medical School)
"Looking at homolog pairing" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Oliver Rando (University of Massachusetts-Worcester)
"Chromatin dynamics in fungi: from 15 minutes to 1 billion years" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Stuart Austin (NCI/Frederick) "Dynamic mapping of the replicating E.coli chromosome shows it to be a hollow tube with an origin segregation machine within its central void"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Rachel O'Neill (University of Connecticut)
"The role of ncRNA in centromeres: lessons from marsupials" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Dhruba Chattoraj (NIH) "Replication of Vibrio cholerae chromosome II: Features that endow a plasmid-like origin to function in a cell-cycle specific fashion" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | John Marko (Northwestern University) "Micromechanics and structure of mitotic chromosomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CHROMOSOME ARCHITECTURE |
| Discussion Leader: Oliver Rando (University of Massachusetts-Worcester) |
7:30 pm - 7:50 pm | Rebecca Heald (University of California-Berkeley)
"Mitotic chromosome compaction and scaling in Xenopus" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Olivier Espeli (CNRS)
"Control of sister chromatid cohesion in bacteria" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Job Dekker (University of Massachusetts-Worcester)
"Folding principles of genomes" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Kerstin Bystricky-Weiss (University of Toulouse) "Dissecting chromatin conformation and dynamics in 3D" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Christopher Weitzel (Brandeis University) "Transcription-dependent, H-NS mediated organization of the E. coli chromosome into a toroid"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CHROMOSOME TOPOLOGY AND REPLICATION |
| Discussion Leader: Olivier Espeli (CNRS) |
9:00 am - 9:20 am | Joaquim Roca Bosch (Instituto de Biologia Molecular de Barcelona, CSIC)
"DNA torsional stress in chromatin biology" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Terry Orr-Weaver (MIT)
"Differential DNA replication: Developmental control of replication initiation and fork progression" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Pat Higgins (University of Alabama Medical School)
"The Impact of Gyrase, Topo I, and mobile DNA on the DNA topology of highly transcribed genes" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Alan Leonard (Florida Institute of Technology)
"OriC nucleotide sequences direct assembly of pre-replication complexes in E. coli" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ken Marians (Memorial Sloan Kettering Institute)
"Physical and functional interaction between the condensin MukB and the decatenase Topoisomerase IV" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Thomas Beattie (University of Oxford) "The role of the DNA sliding clamp in lagging strand DNA replication" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Steven Jacobsen (University of California, Los Angeles) "Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | CHROMOSOME REPAIR AND RECOMBINATION |
| Discussion Leader: Terry Orr-Weaver (MIT) |
7:30 pm - 7:50 pm | James Haber (Brandeis University) "Repair of a broken chromosome" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Virginia Zakian (Princeton University)
"Role of Pif1 family helicases in genome maintenance" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Jinmin Gao (Harvard Medical School)
"Maintaining genomic integrity and promoting chromosome synapsis in C. elegans" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Syam Anand (University of Pittsburgh) "Translocation of PcrA helicase is insufficient to displace RecA from DNA" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Liisa Kauppi (Sloan-Kettering Institute) "How much is enough? Reduced meiotic double-strand breaks result in chromosome pairing defects in mice"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Yasushi Hiraoka (Osaka University) "Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CHROMOSOME SEGREGATION |
| Discussion Leader: Virginia Zakian (Princeton University) |
9:00 am - 9:20 am | Doug Koshland (University of California-Berkeley)
"When RNA goes rogue" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Frank Uhlmann (Cancer Research UK)
"A molecular view of mitotic chromosome condensation" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | David Rudner (Harvard Medical School)
"Chromosome remodeling and translocation during sporulation in Bacillus subtilis" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Camilla Sjogren (Karolinska Institute)
"The Smc5/6 complex and chromosome topology" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hironori Funabiki (Rockefeller University)
"Roles of histone modifications during mitosis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Barbara Funnell (University of Toronto) "P1 plasmid partition involves an ATP-driven association between the plasmid and the bacterial nucleoid via a dynamic adaptor complex" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Christian Haering (EMBL) "Condensin structures chromosomal DNA through topological links" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TELOMERES AND CENTROMERES |
| Discussion Leader: Frank Uhlmann (Cancer Research UK) |
7:30 pm - 7:50 pm | Julie Cooper (Cancer Research UK)
"Telomeres and the challenges to chromosome integrity" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Joachim Lingner (Swiss Institute for Experimental Cancer Research - ISREC)
"Regulation of telomerase at chromosome ends" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gary Karpen (Lawrence Berkeley Laboratory)
"Chromatin regulation of genome stability" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Laura Burrack (University of Minnesota) "Flexibility of kinetochore size and position in Candida albicans" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Katsumi Kitagawa (Research Institute at Nationwide Children's Hospital)
"CENP-A ubiquitylation by the CUL4-RBX1-COPS8 E3 ligase is required for CENP-A loading at centromeres"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |