| SUNDAY | 
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) | 
| 6:00 pm | Dinner | 
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff | 
| 7:40 pm - 9:30 pm | FUNCTIONAL ORGANIZATION OF CHROMOSOMES | 
 | Discussion Leader: Sue Lovett (Brandeis University) | 
| 7:40 pm - 8:20 pm	 | David Sherratt (University of Oxford)  
"Watching molecules one by one in DNA replication and chromosome segregation" | 
| 8:20 pm - 8:35 pm	 | Discussion | 
| 8:35 pm - 9:15 pm	 | Susan Gasser (Friendrich Miescher Institute for Biomedical Reseach)  
"The biology of DNA dynamics: how remodelers facilitate repair" | 
| 9:15 pm - 9:30 pm	 | Discussion | 
| MONDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | VIEWS OF CHROMOSOMES AND CHROMOSOMAL PROTEINS | 
 | Discussion Leader: David Sherratt (Oxford University) | 
| 9:00 am - 9:20 am	 | James Berger (University of California-Berkeley)  
"Molecular mechanisms for initiating DNA replication" | 
| 9:20 am - 9:30 am	 | Discussion | 
| 9:30 am - 9:50 am	 | Nancy Kleckner (Harvard University) "The living E.coli nucleoid: structure, mechanics and short-time-scale dynamics" | 
| 9:50 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:20 am	 | Xiaowei Zhuang (Harvard University)  
"Single-molecule studies of chromosome dynamics and remodeling" | 
| 10:20 am - 10:30 am	 | Discussion | 
| 10:30 am - 11:00 am	 | Group Photo / Coffee Break | 
| 11:00 am - 11:20 am	 | Maria Spies (University of Illinois-Urbana Champaign)   
"Sorting posttranslationally modified DNA repair machines in single-molecule studies" | 
| 11:20 am - 11:30 am	 | Discussion  | 
| 11:30 am - 11:50 am	 | Kiyoshi Muzuuichi (NIDDK)  
"Visualizing the assembly and disassembly of segregation machines" | 
| 11:50 am - 12:00 pm	 | Discussion  | 
| 12:00 pm - 12:10 pm	 | Kazuhiro Maeshima (National Institute of Genetics, Mishima) "Mitotic chromosome structure: irregular folding of nucleosome fibers without the 30-nm chromatin fiber" | 
| 12:10 pm - 12:15 pm	 | Discussion | 
| 12:15 pm - 12:25 pm	 | Thomas Maresca (University of Massachusetts, Amherst) "Regulation of kinetochore-microtubule attachment by mitotic forces" | 
| 12:25 pm - 12:30 pm	 | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | CHROMOSOME INTERACTIONS | 
 | Discussion Leader: James Berger (University of California-Berkeley) | 
| 7:30 pm - 7:50 pm	 | Jennifer Fung (UCSF)  
"Kinetics of chromosome synapsis during meiosis" | 
| 7:50 pm - 8:00 pm	 | Discussion | 
| 8:00 pm - 8:20 pm	 | Aaron Straight (Stanford University)  
"In vitro centromere and kinetochore assembly on reconstituted centromeric chromatin" | 
| 8:20 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:50 pm	 | Abby Dernburg (University of California-Berkeley)  
"Dynamics of homolog interactions during meiosis" | 
| 8:50 pm - 9:00 pm	 | Discussion | 
| 9:00 pm - 9:10 pm	 | Jorge Schvartzman  (Centro de Investigaciones Biologicas, CSIC)  "Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication" | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:25 pm	 | Kingsley Boateng (NIDDK) "Novel early homolog pairing independent of meiotic double-strand breaks and homologous recombination during mammalian meiosis" | 
| 9:25 pm - 9:30 pm	 | Discussion | 
| TUESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | GENOME STRUCTURE AND EVOLUTION | 
 | Discussion Leader: Abby Dernburg (University of California-Berkeley) | 
| 9:00 am - 9:20 am	 | David Pellman (Harvard Medical School)  
 "Chromosome breaks from errors in mitosis" | 
| 9:20 am - 9:30 am	 | Discussion | 
| 9:30 am - 9:50 am	 | Ting Wu (Harvard Medical School)  
"Looking at homolog pairing" | 
| 9:50 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:20 am	 | Oliver Rando (University of Massachusetts-Worcester)  
"Chromatin dynamics in fungi: from 15 minutes to 1 billion years" | 
| 10:20 am - 10:30 am	 | Discussion | 
| 10:30 am - 11:00 am	 | Coffee Break | 
| 11:00 am - 11:20 am	 | Stuart Austin (NCI/Frederick)  "Dynamic mapping of the replicating E.coli chromosome shows it to be a hollow tube with an origin segregation machine within its central void"
  | 
| 11:20 am - 11:30 am	 | Discussion  | 
| 11:30 am - 11:50 am	 | Rachel O'Neill (University of Connecticut)   
"The role of ncRNA in centromeres: lessons from marsupials" | 
| 11:50 am - 12:00 pm	 | Discussion  | 
| 12:00 pm - 12:10 pm	 | Dhruba Chattoraj (NIH)  "Replication of Vibrio cholerae chromosome II: Features that endow a plasmid-like origin to function in a cell-cycle specific fashion" | 
| 12:10 pm - 12:15 pm	 | Discussion | 
| 12:15 pm - 12:25 pm	 | John Marko (Northwestern University)  "Micromechanics and structure of mitotic chromosomes" | 
| 12:25 pm - 12:30 pm	 | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | CHROMOSOME ARCHITECTURE | 
 | Discussion Leader: Oliver Rando (University of Massachusetts-Worcester) | 
| 7:30 pm - 7:50 pm	 | Rebecca Heald (University of California-Berkeley)  
"Mitotic chromosome compaction and scaling in Xenopus" | 
| 7:50 pm - 8:00 pm	 | Discussion | 
| 8:00 pm - 8:20 pm	 | Olivier Espeli (CNRS)  
 "Control of sister chromatid cohesion in bacteria" | 
| 8:20 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:50 pm	 | Job Dekker (University of Massachusetts-Worcester)  
"Folding principles of genomes" | 
| 8:50 pm - 9:00 pm	 | Discussion | 
| 9:00 pm - 9:10 pm	 | Kerstin Bystricky-Weiss (University of Toulouse)  "Dissecting chromatin conformation and dynamics in 3D" | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:25 pm	 | Christopher Weitzel (Brandeis University) "Transcription-dependent, H-NS mediated organization of the E. coli chromosome into a toroid"
 | 
| 9:25 pm - 9:30 pm	 | Discussion | 
| WEDNESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | CHROMOSOME TOPOLOGY AND REPLICATION | 
 | Discussion Leader: Olivier Espeli (CNRS) | 
| 9:00 am - 9:20 am	 | Joaquim Roca Bosch (Instituto de Biologia Molecular de Barcelona, CSIC)  
"DNA torsional stress in chromatin biology" | 
| 9:20 am - 9:30 am	 | Discussion | 
| 9:30 am - 9:50 am	 | Terry Orr-Weaver (MIT)  
"Differential DNA replication: Developmental control of replication initiation and fork progression" | 
| 9:50 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:20 am	 | Pat Higgins (University of Alabama Medical School)  
"The Impact of Gyrase, Topo I, and mobile DNA on the DNA topology of highly transcribed genes" | 
| 10:20 am - 10:30 am	 | Discussion | 
| 10:30 am - 11:00 am	 | Coffee Break | 
| 11:00 am - 11:20 am	 | Alan Leonard (Florida Institute of Technology)   
"OriC nucleotide sequences direct assembly of pre-replication complexes in E. coli" | 
| 11:20 am - 11:30 am	 | Discussion  | 
| 11:30 am - 11:50 am	 | Ken Marians (Memorial Sloan Kettering Institute)  
"Physical and functional interaction between the condensin MukB and the decatenase Topoisomerase IV" | 
| 11:50 am - 12:00 pm	 | Discussion  | 
| 12:00 pm - 12:10 pm	 | Thomas Beattie (University of Oxford)  "The role of the DNA sliding clamp in lagging strand DNA replication" | 
| 12:10 pm - 12:15 pm	 | Discussion | 
| 12:15 pm - 12:25 pm	 | Steven Jacobsen (University of California, Los Angeles) "Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases"
 | 
| 12:25 pm - 12:30 pm	 | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:00 pm - 7:30 pm | Business Meeting | 
 | Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair | 
| 7:30 pm - 9:30 pm | CHROMOSOME REPAIR AND RECOMBINATION | 
 | Discussion Leader: Terry Orr-Weaver (MIT) | 
| 7:30 pm - 7:50 pm	 | James Haber (Brandeis University) "Repair of a broken chromosome" | 
| 7:50 pm - 8:00 pm	 | Discussion | 
| 8:00 pm - 8:20 pm	 | Virginia Zakian  (Princeton University)  
"Role of Pif1 family helicases in genome maintenance" | 
| 8:20 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:40 pm	 | Jinmin Gao  (Harvard Medical School)  
"Maintaining genomic integrity and promoting chromosome synapsis in C. elegans" | 
| 8:40 pm - 8:45 pm	 | Discussion | 
| 8:45 pm - 8:55 pm	 | Syam Anand (University of Pittsburgh)  "Translocation of PcrA helicase is insufficient to displace RecA from DNA" | 
| 8:55 pm - 9:00 pm	 | Discussion | 
| 9:00 pm - 9:10 pm	 | Liisa Kauppi  (Sloan-Kettering Institute)  "How much is enough? Reduced meiotic double-strand breaks result in chromosome pairing defects in mice"
 | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:25 pm	 | Yasushi Hiraoka (Osaka University) "Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis"
 | 
| 9:25 pm - 9:30 pm	 | Discussion | 
| THURSDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | CHROMOSOME SEGREGATION | 
 | Discussion Leader: Virginia Zakian (Princeton University)  | 
| 9:00 am - 9:20 am	 | Doug Koshland (University of California-Berkeley)  
"When RNA goes rogue" | 
| 9:20 am - 9:30 am	 | Discussion | 
| 9:30 am - 9:50 am	 | Frank Uhlmann (Cancer Research UK)  
"A molecular view of mitotic chromosome condensation" | 
| 9:50 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:20 am	 | David Rudner (Harvard Medical School)  
"Chromosome remodeling and translocation during sporulation in Bacillus subtilis" | 
| 10:20 am - 10:30 am	 | Discussion | 
| 10:30 am - 11:00 am	 | Coffee Break | 
| 11:00 am - 11:20 am	 | Camilla Sjogren (Karolinska Institute)  
"The Smc5/6 complex and chromosome topology" | 
| 11:20 am - 11:30 am	 | Discussion  | 
| 11:30 am - 11:50 am	 | Hironori Funabiki (Rockefeller University)   
"Roles of histone modifications during mitosis" | 
| 11:50 am - 12:00 pm	 | Discussion  | 
| 12:00 pm - 12:10 pm	 | Barbara Funnell (University of Toronto) "P1 plasmid partition involves an ATP-driven association between the plasmid and the bacterial nucleoid via a dynamic adaptor complex" | 
| 12:10 pm - 12:15 pm	 | Discussion | 
| 12:15 pm - 12:25 pm	 | Christian Haering (EMBL)  "Condensin structures chromosomal DNA through topological links" | 
| 12:25 pm - 12:30 pm	 | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | TELOMERES AND CENTROMERES | 
 | Discussion Leader: Frank Uhlmann (Cancer Research UK) | 
| 7:30 pm - 7:50 pm	 | Julie Cooper (Cancer Research UK)  
"Telomeres and the challenges to chromosome integrity" | 
| 7:50 pm - 8:00 pm	 | Discussion | 
| 8:00 pm - 8:20 pm	 | Joachim Lingner (Swiss Institute for Experimental Cancer Research - ISREC)  
"Regulation of telomerase at chromosome ends" | 
| 8:20 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:50 pm	 | Gary Karpen (Lawrence Berkeley Laboratory)  
"Chromatin regulation of genome stability" | 
| 8:50 pm - 9:00 pm	 | Discussion | 
| 9:00 pm - 9:10 pm	 | Laura Burrack (University of Minnesota)   "Flexibility of kinetochore size and position in Candida albicans" | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:25 pm	 | Katsumi Kitagawa (Research Institute at Nationwide Children's Hospital)
 "CENP-A ubiquitylation by the CUL4-RBX1-COPS8 E3 ligase is required for CENP-A loading at centromeres"
 | 
| 9:25 pm - 9:30 pm	 | Discussion | 
| FRIDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am | Departure |