SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Chromosome Dynamics: From nucleotides to chromosomes |
| Discussion Leader: Julie Cooper (Cancer Research UK Lincoln's Inn Fields Laboratories) |
7:40 pm - 8:30 pm | Keynote Lecture: Tomas Lindahl (Cancer Research UK Clare Hall Laboratories)
"Intrinsic DNA damage and degradation of ssDNA in mammalian cell nuclei" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | John Marko (Northwestern University, Chicago)
"Micromechanical analysis of chromosome-folding proteins and of whole chromosomes" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Views of Chromosomes |
| Discussion Leader: James Berger (University of California, Berkeley) |
9:00 am - 9:20 am | James Berger (University of California, Berkeley)
"How far does the rabbit hole go: plumbing the depths of molecular control in a DNA disentangling machine (and not hitting bottom)" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Steve Harrison (Harvard Medical School)
"Molecular architecture of kinetochores |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Kazuhiro Maeshima (National Institute of Genetics, Mishima)
"Local structural similarity between interphase chromatin and mitotic chromosomes in living mammalian cells" |
10:10 am - 10:15 am | Discussion |
10:15 am | Group Photo / Coffee Break |
10:45 am - 11:05 am | Barbara Funnell (University of Toronto)
"P1 ParA and plasmid dynamics on the bacterial nucleoid" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Tatsuya Hirano (RIKEN Advanced Science Institute)
"Functional dissection of condensin I by using recombinant subunits" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Peter Fraser (Babraham Institute, Cambridge)
"Single cell analysis of chromosome structure" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Damien Hudson (Murdoch Childrens Research Institute, Australia)
"Genome-wide map and analysis of condensin I binding sites in vertebrates" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Chromosome Interactions |
| Discussion Leader: Abby Dernburg (University of California, Berkeley) |
5:30 pm - 5:50 pm | Abby Dernburg (University of California, Berkeley)
"Feedback regulation of chromosome transactions during meiotic prophase" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Yasushi Hiraoka (Osaka University)
"Inner nuclear membrane proteins that affect chromosome dynamics in fission yeast" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Nancy Kleckner (Harvard University)
"Chromosome dynamics: from meiotic chromosomes to mitotic chromosomes by way of E.coli" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Xindan Wang (Harvard Medical School)
"Bacillus subtilis chromosome organization alternates between two distinct patterns" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Kimberly Collins (Stowers Institute)
"Corolla encodes a central element protein within the Drosophila synaptonemal complex" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Structure and Evolution |
| Discussion Leader: David Sherratt (University of Oxford) |
9:00 am - 9:20 am | David Sherratt (University of Oxford)
"Architecture of the Escherichia coli SMC complex, MukBEF, and its action in chromosome segregation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Daniela Barilla (University of York)
"Life pushed to extremes: genome segregation in archaea" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Ann Kirchmaier (Purdue University)
"Epigenetic profiling at single cell and single molecule resolution" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Bas van Steensel (NKI Amsterdam)
"Probing chromatin position effects in high-throughput mode" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Nick Luscombe (University College London)
"Computational analyses of nuclear organisation and gene expression" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Frederic Boccard (CNRS-CGM, Gif-sur-Yvette)
"Structuring the Ter macrodomain of the E. coli chromosome: mechanisms and consequences" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Makkuni Jayaram (University of Texas, Austin)
"Germ line propagation of a selfish DNA element by engaging a meiotic motor system and motor associated telomeres" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sarah Zanders (Fred Hutchinson Cancer Research Center)
"How to cheat at sex and win: meiotic drive in fission yeast" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Chromosome Architecture |
| Discussion Leader: John Marko (Northwestern University, Chicago) |
5:30 pm - 5:50 pm | Edith Heard (Institut Curie, Paris)
"Dynamic changes in chromosome structure and chromatin content during X inactivation" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Olivier Espeli (CNRS Centre de Génétique Moléculaire, Gif-sur-Yvette)
"Control of sister chromatid cohesion in E. coli" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Yves Barral (ETH Zurich)
"Partitioning DNA circles away from bona fide chromosomes" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Remus Dame (Leiden University)
"Unravelling the role of chromatin proteins in archaeal nucleoid organization" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | James Taylor (University of Bristol)
"Interactions between the SMC-complex, Spo0J and DNA" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromosome Replication |
| Discussion Leader: Sue Lovett (Brandeis University) |
9:00 am - 9:20 am | Sue Lovett (Brandeis University)
"Bacterial chromosome compaction and dynamics" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | John Diffley (Cancer Research UK Clare Hall Laboratories)
"Mechanism of DNA replication origin licensing" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jorge Schvartzman (Centro de Investigaciones Biologicas, Madrid)
"Topoisomerases are dispensable for the replication and segregation of yeast artificial chromosomes (YACs)" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Pat Higgins (University of Alabama Medical School)
"Mechanism of linkage between rates of type-2 topoisomerase turnover and transcription elongation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Kirsten Skarstad (University of Oslo)
"Organization of newly synthesized DNA in Escherichia coli" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Vincent Croquette (Ecole Normale Superieure, Paris)
"Single-molecule study of the T4 replisome and its rescue by fork reversion mediated by UvsW" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Karl Duderstadt (University of Groningen)
"Single replication machines at work: the coordination of daughter strand synthesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Chromosome Repair and Recombination |
| Discussion Leader: David Rudner (Harvard Medical School) |
5:30 pm - 5:50 pm | Graham Walker (Massachusetts Institute of Technology)
"Translesion DNA polymerases: From chemotherapy to bactericidal antibiotics" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Karl-Peter Hopfner (University of Munich)
"Structural mechanisms of DNA double-strand break repair enzymes" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Scott Keeney (Memorial Sloan-Kettering Cancer Center)
"Mechanism and regulation of meiotic recombination initiation" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Kerstin Bystricky (University of Toulouse)
"Early steps of double-strand break processing revealed by non-intrusive imaging of DNA loci in living cells" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Emanuelle Fabre (Institut Pasteur)
"Effect of nuclear architecture on the efficiency of double-strand break repair" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromosome Segregation |
| Discussion Leader: Rebecca Heald (University of California, Berkeley) |
9:00 am - 9:20 am | Rebecca Heald (University of California, Berkeley)
"Investigating mitotic chromosome size and dynamics in Xenopus" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jef Boeke (Johns Hopkins University)
"Synthesizing and scrambling yeast chromosomes" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Christian Haering (EMBL, Heidelberg)
"Topological linkage by condensin rings prevents chromosome breakage" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Jan Loewe (MRC Laboratory of Molecular Biology, Cambridge)
"Bacterial plasmid segregation mechanisms" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Jeff Errington (University of Newcastle)
"Chromosome dynamics and the spatial regulation of cell division in B. subtilis" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Stephan Gruber (Max Planck Institute of Biochemistry, Martinsried)
"Architecture of a prototype SMC-kleisin complex: Smc-ScpA-ScpB" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Ginger Zakian (Princeton University)
"Preventing de novo telomere addition: helicases to the rescue" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Centromeres and Telomeres |
| Discussion Leader: Aaron Straight (Stanford University) |
5:30 pm - 5:50 pm | Julie Cooper (Cancer Research UK Lincoln's Inn Fields Laboratories)
"Telomeres and nuclear microenvironments: surprising means and ends" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Francois Cornet (CNRS, Toulouse)
"Active segregation of chromosome ends in bacteria"
|
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Stephane Marcand (CEA, Fontenay-aux-Roses)
"Dicentric chromosomes breakage at centromeres"
|
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Aaron Straight (Stanford University)
"Chromatin specialization and the assembly of metazoan centromeres" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Joseph Loparo (Harvard Medical School)
"The Bacillus subtilis ParB protein Spo0J spreads by trapping DNA loops" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Anthony Vecchiarelli (NIDDK, National Institutes of Health)
"Surfing the Bacterial Nucleoid: A key role for Spatial Confinement in ParA-mediated Partition and Transport" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |