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Chromosome Dynamics

Gordon Research Conference

Chromosome Biology From Cellular, Molecular and Physical Perspectives

June 25 - 30, 2023

Chair Camilla Björkegren

Vice Chair Steve Bell

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Chromosome Dynamics GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Deciphering the regulation and functional consequences of chromosome dynamics is essential for our understanding of cellular function, organism survival and development of disease. Having evolved from the study of inherited traits in pea plants, the field of chromosome biology now encompasses a large number of model systems in all three domains of life and exploits approaches ranging from cell-, molecular- and structural biology to biophysics and computational modelling. The conference aims to bring together scientists from all areas of chromosome research to share new results and ideas. By gathering an international and diverse group of researchers, the conference will promote collaborations, accelerate young scientists’ career advancement and direct future development of the field.

Related Meeting

This GRC will be held in conjunction with the "Chromosome Dynamics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Chromosomes: From Molecules to Cells and Organisms Discussion Leader: John Marko (Northwestern University, United States)
7:40 pm - 7:45 pm	General Discussion
7:45 pm - 8:10 pm	Susan Gasser (ISREC Foundation, Switzerland) "Chromatin and Chromosomal domains: The Antagonism of Eu- and Hetero-Chromatin"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	Geeta Narlikar (University of California, San Francisco, United States) "Alexander M. Cruickshank Lecture: Mechanisms of Chromatin Remodeling Machines: Different or the Same?"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	Romain Koszul (Institut Pasteur / CNRS, France) "Using Exogenous Chromosomes to Explore how Sequence Composition Drives Chromatin Assembly, Activity and 3D Folding"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chromosome Organization and Gene Regulation Discussion Leader: Katsuhiko Shirahige (Institute for Quantitative Biosciences, The University of Tokyo, Japan)
9:00 am - 9:20 am	Wendy Bickmore (MRC Human Genetics Unit, United Kingdom) "Reconciling Different Views of Enhancer-Promoter Interaction: Seeing is Believing?"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Shanelle Mullany (University of Toronto, Canada) "Euchromatin Hopping; Active Enhancers Drive Accessibility, Histone Modifications, RNA- Polymerase Recruitment, and Transcription at Distal Chromatin Through a Chromatin loop Mechanism"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Daniele Canzio (UCSF, United States) "The role of Genome Architecture in Shaping Brain Architecture"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Molly Zych (Fred Hutchinson Cancer Center, United States) "Micronucleus chromatin state Influences Lamina Structure and Stability Through Nuclear Growth"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Imke Mandemaker (Hubrecht Institute, The Netherlands) "The Histone Chaperone ANP32B Regulates Chromatin Incorporation of the Atypical Human Histone Variant MacroH2A"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Hitoshi Kurumizaka (Institute for Quantitative Biosciences, The University of Tokyo, Japan) "Cryo-EM Studies of Chromatin Structure and Dynamics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Yasuhiro Arimura (Rockefeller University, United States) "Sub-Nanometer Resolution Structural Features of Chromatin-Related Complexes in Chromosomes"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Viviana Risca (The Rockefeller University, United States) "Probing Sub-kilobase Chromatin Fiber Folding and Its Regulation by Linker Histones"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Ana Stankovic (Brain Research Institute, University of Zurich, Switzerland) "Repurposing of CENP-A Chromatin for Neuronal Activation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Stefan Niekamp (Massachusetts General Hospital & Harvard Medical School, United States) "Polycomb Repressive Complex I Composition and Nucleosomal Scaffold Properties Determine Extend of Chromatin Condensation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Coral Zhou (University of California, Berkeley, United States) and Susan Gasser (ISREC Foundation, Switzerland)
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Chromosome Replication Discussion Leader: Susan Lovett (Brandeis University, United States)
6:00 pm - 6:20 pm	Rodrigo Reyes Lamothe (McGill University, Canada) "Fast DNA Polymerase Target Search Stabilizes the Bacterial Replisome"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Remi Sonneville (MRC-PPU - University of Dundee, United Kingdom) "DNSN-1 Recruits GINS for CMG Helicase Assembly During DNA Replication Initiation in Caenorhabditis Elegans"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	John Diffley (The Francis Crick Institute, United Kingdom) "The Initiation of Eukaryotic DNA Replication: Mechanism, Regulation and Misregulation"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Paul Wiggins (University of Washington, United States) "The in vivo Measurement of Replication Fork Velocity and Pausing by lag-time Analysis"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Francesca Mattiroli (Hubrecht Institute, The Netherlands) "Mechanism of de novo Chromatin Assembly During DNA Replication"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chromosome Instability and Repair Discussion Leader: Julia Cooper (University of Colorado Anschutz Medical Campus, United States)
9:00 am - 9:20 am	Karlene Cimprich (Stanford University School of Medicine, United States) "Mechanisms for the Maintenance of Genome Stability"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Thalia Sass (Brandeis University, United States) "Activation of the RpoS Stress Response & Replication Restart After Transcriptional Conflicts in E. coli"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Pierre-Alexandre Vidi (Institut de Cancérologie de l'Ouest, France) "Chromatin Motions in Response to DNA Damage"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Houra Merrikh (Vanderbilt University, United States) "Inhibiting the Evolution of Drug Resistance"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Gaelle Legube (CBI, CNRS, University of Toulouse, France) "Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Lydia R. Heasley (University of Colorado School of Medicine, United States) "The Karyotypic Landscape of Clonal Populations"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Cristina González Garrido (CSIC, Spain) "Parental Histone Distribution and Location of the Replication Obstacle at Nascent Strands Control Homologous Recombination"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Eric Greene (Columbia University, United States) "Single Molecule Studies of Genetic Recombination"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Meiotic Chromosomes Discussion Leader: Abby Dernburg (University of California, Berkeley, United States)
6:00 pm - 6:20 pm	Jennifer Fung (University of California, San Francisco, United States) "Chromosome Dynamics and the Control of Meiotic Pairing and Synapsis"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Anuradha Mukherjee (Wellcome Trust Centre for Cell Biology, University of Edinburgh, United Kingdom) "Homolog Biorientation in Meiosis I Requires Non-Canonical Functions of Spindle Checkpoint proteins"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	Hasibe Tuncay Elbasi (University of Hamburg, Germany) "Control of male Meiosis by DREAM Complex"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	Ana Cobos (European Molecular Biology Laboratory (EMBL), Germany) "RNA in Pairing Centers in C. Elegans Meiosis"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Dipesh kumar Singh (Max planck institute for plant breeding research Cologne, Germany) "HEIP1 is Required for Efficient Meiotic Crossover Implementation and is Conserved from Plants to Humans"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Franz K. Klein (Max Perutz Laboratories, University of Vienna, Austria) "Disassembling and Reassembling the Synaptonemal Complex in Vivo"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Genome Organization Discussion Leader: Coral Zhou (University of California, Berkeley, United States)
9:00 am - 9:20 am	Xindan Wang (Indiana University, United States) "Organization of a Multipartite Bacterial Genome"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Maximilian Spicer (Institute of Molecular Biotechnology (IMBA), Vienna, Austria) "Chromatin Compaction: A Matter of Life and Death"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Coral Zhou (University of California, Berkeley, United States) "Mechanisms of Genome Scaling During Embryogenesis and Evolution"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Lu Gan (National University of Singapore, Singapore) "Non-Canonical Insights from in Situ Cryo-ET Studies of Yeast Chromatin"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	Ana Losada (Spanish National Cancer Research Centre, Spain) "Mechanisms of Cohesin-STAG1 and Cohesin-STAG2 Specificity"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	Roman Barth (Technische Universiteit Delft, The Netherlands) "Cohesin is not a Symmetric, but a Sequentially Unidirectional DNA loop Extruder"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	Benjamin Rowland (The Netherlands Cancer Institute, The Netherlands) "Genome control by cohesin"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Naomichi Takemata (Kyoto University, Japan) "Molecular Mechanism of SMC-Mediated Domain Formation in Archaea"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Elham Ghobadpour (Centre National de la Recherche Scientifique (CNRS), France) "Multiple Scale Polymer Model of Bacterial Chromosome Organisation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Centromere Structure and Function Discussion Leader: Aaron Straight (Stanford University School of Medicine, United States)
6:00 pm - 6:20 pm	Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom) "Epigenetic Regulation, Heterochromatin and Antifungal Resistance"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Julia Schweighofer (Max Planck Institute of Molecular Physiology, Dortmund, Germany) "Centromere-Enriched Histone Chaperone FACT Associates Directly with the Inner Kinetochore"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	Duccio Conti (Max Planck Institute of Molecular Physiology, Germany) "Insights into the role of PLK1 in the Epigenetic Maintenance of Centromeres"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Jennifer Gerton (Stowers Institute for Medical Research, United States) "Defining a core Configuration for Human Centromeres During Mitosis"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Mihailo Mirkovic (ETH Zurich, Switzerland) "Introns drive Asymmetric Chromosome Inheritance in Ageing"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Martina Richeldi (The Francis Crick Institute, United Kingdom) "Mechanical Disengagement of the Cohesin Ring"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Chromosomes, DNA and Supercoiling Discussion Leader: Adele Marston (University of Edinburgh, United Kingdom)
9:00 am - 9:20 am	Marco Foiani (IFOM ETS - The AIRC Institute of Molecular Oncology, Italy) "Topological Mechanisms Mediating Intra and Inter-Chromosomal Interactions"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Olivier Espeli (College de France - CIRB, France) "Transcriptional Units form the Elementary Constraining Building Blocks of the Bacterial Chromosome"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Andres Canela (Kyoto University, Japan) "MukBEF Ensures Proper Chromosome Segregation of Highly Transcribed Regions"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Laura Baranello (Karolinska Institutet, Sweden) "The Regulation of Transcription by Topoisomerases, Supercoiling and MYC"
10:50 am - 11:00 am	Discussion
11:00 am - 11:10 am	Eugene Kim (Max-Planck Institute of Biophysics, Germany) "Revealing Mechanism of Smc5/6-Mediated DNA loop Extrusion"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	Xiaolan Zhao (Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, United States) "Cryo-EM Structures of Smc5/6 Provide Insights into its Assembly and Functional Mechanisms"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	Ànnia Carré Simon (INSERM, France) "Genome Stability: Interplay Between Double Strand Break (DSB), Chromatin Mobility and SMC Complexes"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Nynke Dekker (TU Delft, The Netherlands) "Single-Molecule Studies of Chromatin Replication"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Frederic BECKOUET (CBI, CNRS, France) "Cohesin Dynamics Controls Epansion of DNA Loop by SMC Complexes"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Structural Maintenance of Chromosomes Discussion Leader: Frank Uhlmann (The Francis Crick Institute, United Kingdom)
6:00 pm - 6:20 pm	Tatsuya Hirano (RIKEN, Japan) "A Tale of Two Condensins: Molecular Dissection of Mitotic Genome Folding Machines"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Alessandro Borsellini (Human Technopole, Italy) "M18BP1 is a Condensin II Loading Factor"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	Stephan Gruber (University of Lausanne, Switzerland) "DNA Topology Sensing in SMC-Based Immunity Systems in Bacteria"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Samson Glaser (The Francis Crick Institute, United Kingdom) "A Single Molecule Approach to Understanding Sister Chromatid Cohesion Establishment"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Jan-Michael Peters (Research Institute of Molecular Pathology (IMP), Austria) "Regulation of Cohesin-Mediated Loop Extrusion by CTCF"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13CA284570-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official polices of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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