SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Circadian control of output, DNA repair (cancer) and physiology |
| Discussion Leader: Marina Antoch (Roswell Park) |
7:40 pm - 8:00 pm | Michael Brunner (Heidelberg)
"Functional Characterization of the FRQ-interacting RNA helicase" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Aziz Sancar (UNC Chapel Hill)
"Control of DNA Repair and Cancer by the Circadian Clock" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Mukesh Jain (Case Western Reserve)
"KLF15 and circadian control of cardiac function" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | TBA (Selected from GRS) |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Systems vs. autonomous control of the clock |
| Discussion Leader: Hiroki Ueda (Riken) |
9:00 am - 9:20 am | Ravi Allada (Northwestern)
"Neural clocks in Drosophila" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Erik Herzog (Wash. U)
"GABA and VIP: A Yin-yang couple for circadian synchrony" |
9:45 am - 9:50 am | Discussion |
9:50 am | Group Photo / Coffee Break |
10:20 am - 10:45 am | Sato Honma (Hokkaido Univ)
"The circadian system in the SCN; genes, development and environments" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:10 am | Maria Ceriani (Fundacion Instituto Leloir Buenos Aires)
"Circadian period integrates network information through activation of the BMP signaling pathway" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Michael Hastings (MRC LMB Cambridge UK)
"Analysis and manipulation of cell-autonomous and network-level circadian pacemaking in the suprachiasmatic nucleus" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | TBA (Selected from GRS) |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Hot topic talk: Sebastian Kadener (The Hebrew University of Jerusalem)
"Clk RNA turnover control denoises circaidan transcription in time and space"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Entrainment: light, temperature, food and other entraining molecules |
| Discussion Leader: Michael Rosbash (Brandeis) |
7:30 pm - 7:50 pm | Ueli Schibler (Geneva)
"Identification of circadian signaling pathways by synthetic tandem repeat promoter (STAR-PROM) screening" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Samer Hattar (Hopkins)
"From molecules to circuits to behavior: how light influences physiology" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Joke Meijer (Leiden Univ Medical Center Holland)
"Light responsiveness and adaptive significance of the circadian system" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Charlotte Helfrich-Förster (Universität Wuerzburg)
"Role of external and internal photoreceptors in timing Drosophila's daily activity" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Hot topic talk: Jeffrey Price (UMKC)
"Noncanonical FK506-binding Protein BDBT Binds DBT and Forms Foci at Night to Promote Circadian Rhythms"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clock mechanisms: transcription, protein turnover, structure, and post-transcriptional mechanisms |
| Discussion Leader: Paul Hardin (Texas A&M) |
9:00 am - 9:20 am | Joseph Takahashi (UT Southwestern)
"Transcriptional architecture of the circadian clock in mammals" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Charles Weitz (Harvard)
"Analysis of the PERIOD complex of the mammalian circadian clock" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Jay Dunlap (Dartmouth)
"Genetic and molecular analysis of the Neurospora clock" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Felix Naef (École Polytechnique Fédérale De Lausanne)
"Mechanisms of phase-specific circadian transcription in mouse liver" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Achim Kramer (Charité Berlin)
"Posttranscriptional control of mammalian circadian rhythms" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Hot topic talk: Frédéric Gachon (Nestlé Institute of Health Sciences)
"Post-transcriptional orchestration of the proteome in the mouse liver: is it a circadian matter?"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Hot topic talk: Carrie Partch (University of California Santa Cruz)
"A slow conformational switch regulates the 24-hour circadian clock"
|
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Non-transcriptional-translational oscillator mechanisms |
| Discussion Leader: Carl Johnson (Vanderbilt) |
7:30 pm - 7:50 pm | Akhilesh Reddy (Univ. Cambridge)
"Redox and metabolic oscillations in the clockwork" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Susan Golden (UC San Diego)
"Intrinsic input and output functions of the Kai oscillator of cyanobacteria" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Erin O'Shea (Harvard)
"Timekeeping with a Three-Protein Circadian Clock" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | John O'Neill (Univ Cambridge)
"Circadian rhythms in erythrocyte redox state, in vitro & in vivo" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Epigenetics and chromatin with an emphasis on aging |
| Discussion Leader: Paloma Mas (Center for Research in Agricultural Genomics, CRAG) |
9:00 am - 9:20 am | Paolo Sassone-Corsi (UC Irvine)
"Coordinated Epigenetic Control by the Clock" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Steve Brown (Univ. Zurich)
"Neural networking and epigenetics within the suprachiasmatic nucleus"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Jürgen Ripperger (Univ Fribourg Switzerland)
"Role of circadian transcription factors in aging"
|
10:05 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Leonard Guarente (MIT)
"Aging-sensitive control of central circadian rhythm by SIRT1" |
10:30 am - 10:35 am | Discussion |
10:35 am | Coffee Break |
11:05 am - 11:25 am | Satchidananda Panda (Salk) |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hot topic talk: Jerome Menet (Brandeis University)
"CLOCK:BMAL1 is a Pioneer-like Transcription Factor"
|
11:50 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | TBA (Selected from GRS) |
12:15 pm - 12:20 am | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Plants including agriculturally or industrially interesting organisms |
| Discussion Leader: Susan Golden (UC San Diego) |
7:30 pm - 7:50 pm | Paloma Mas (Center for Research in Agricultural Genomics, CRAG)
"Chromatin and the Arabidopsis circadian clock: a question of time"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Takeshi Izawa (National Institute of Agrobiological Sciences)
"Time-keeping in rice under fluctuating field conditions"
|
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Alison Smith (John Innes Center)
"Timing starch consumption prevents starvation in Arabidopsis plants" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Daniel Forger (Univ Michigan)
"Supermodels see the light of day: How high performance computing can help the next generation of circadian research" |
9:05 pm - 9:25 pm | Andrew Millar (Univ. Edinburgh)
"Models and infrastructure for systems chronobiology"
|
9:25 pm - 9:30 pm | Combined Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Metabolic diseases II: metabolic syndrome, diabetes and aging |
| Discussion Leader: Amita Sehgal (UPenn) |
9:00 am - 9:20 am | Carla Green (Univ of Texas Southwestern Medical Center)
"Circadian post-transcriptional control of metabolism" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Joe Bass (Northwestern)
"Circadian Control of Bioenergetics and Fuel Selection in Mice" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Gad Asher (Weizmann Institute of Science)
"A cross talk between metabolism and circadian rhythmicity" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | TBA (Selected from GRS) |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Hot topic talk: Erik Musiek (Washington University School of Medicine)
"Impairment of the positive limb of the core circadian clock disrupts neuronal redox homeostasis and promotes neurodegeneration"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | TBA (Selected from GRS) |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Masashi Yanagisawa (UT Southwestern Medical Center/HHMI and Univ of Tsukuba)
"Forward genetic analysis of sleep in ENU-mutagenized mice: Identification of pedigrees with heritable sleep/wake abnormalities"
|
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Sleep |
| Discussion Leader: Mike Young (Rockefeller) and Mehdi Tafti (Lausanne) |
7:30 pm - 7:50 pm | Amita Sehgal (UPenn)
"Molecular and cellular circuits underlying Drosophila behavior"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Paul Shaw (Washington Univ of St. Louis)
"Enhanced sleep reverses cognitive impairment in classic memory-mutants" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Leslie Griffith (Brandeis Univ)
"Peptidergic regulation of sleep in Drosophila" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Paul Franken (Univ Lausanne)
"Sleep homeostasis and circadian rhythms: shared molecular pathways?" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |