Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Beyond Circadian Oscillations
Discussion Leader: Carl Johnson (Vanderbilt University, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Tobias Kaiser (Max Planck Institute for Evolutionary Biology, Germany)
"How Evolution's Signatures Shed New Light on Circalunar and Circadian Clocks"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Erquan Zhang (National Institute of Biological Sciences, China)
"Hypoxia Adaptation Cripples the Circadian Clock in Tibetan Plateau Pika"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
John O'Neill (MRC Laboratory of Molecular Biology, United Kingdom) and Helen Causton (Columbia University Medical Center, USA)
"Metabolic Rhythms in Yeast"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Milou Meeuse (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Mechanisms of a Developmental Clock in C. elegans "
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Insights into Clock Mechanisms and Outputs
Discussion Leader: Deborah Bell-Pedersen (Texas A&M University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Anita Gondor (Karolinska Institutet, Sweden)
"The Circadian Clock Collaborates with 3D Genome Organizers in the Regulation of Oscillating Transcription"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Achim Kramer (Charité - Universitätsmedizin Berlin, Germany)
"Posttranscriptional Mechanism in the Mammalian Circadian Clock"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yi Liu (University of Texas Southwestern Medical Center, USA)
"Codon Usage of Clock Proteins Uncovers a New Code Within Genetic Codons"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Andy Liwang (University of California, Merced, USA)
"Real-Time Observations of a Circadian Clock at Atomic Resolution"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Joseph Takahashi (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, USA)
"Transcriptional Architecture of the Mammalian Circadian Clock"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Carla Finkielstein (Virginia Tech, USA)
"Interplay Between E3 Ligases Modulate Period 2's Accumulation and Influences Circadian Oscillations"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Paul Humphries (Reset Therapeutics, USA)
"Cry Modulators: From the Bench to the Clinic"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Circadian Regulation in
Multi-Oscillator Systems
Discussion Leader: John Hogenesch (Cincinnati Children's Hospital Medical Center, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
John Ewer (Centro Interdisciplinario de Neurociencia, Universidad de Valparaíso, Chile)
"Control of Drosophila Ecdysis by Peptidergic Circadian Oscillators"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Stacey Harmer (University of California, Davis, USA)
"Circadian Tracking in Sunflowers"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Paolo Sassone-Corsi (University of California, Irvine, USA)
"Cross-Talk Between Circadian Oscillators in Mammals"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Hiroki Ueda (The University of Tokyo / RIKEN (QBiC), Japan)
"Towards System-Level Understanding of Period-Determining Mechanisms in Mammalian Clock and Sleep"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Interaction Between Clocks
and Metabolism
Discussion Leader: Carla Green (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Joseph Bass (Northwestern University, USA)
"Circadian Regulation of Cellular Metabolic Activity"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jay Dunlap (Geisel School of Medicine, Dartmouth College, USA)
"Circadian Control of Fat Metabolism"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sibel Kayitmazbatir (Koc University, Turkey)
"Physical Interaction Between CRY1 and CBS Provide Bi-Directional Regulation in both Circadian Clock Function and Metabolism"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Filipa Rijo-Ferreira (University of Texas Southwestern Medical Center, USA)
"Trypanosoma brucei Metabolism Is Under Circadian Control"
10:25 am - 10:30 am
Discussion
10:30 am - 10:35 am
General Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Gianluca Tosini (Morehouse School of Medicine, USA)
"Melatonin Signaling Modulates Insulin Sensitivity"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michelle Gumz (University of Florida, USA)
"Per1 and the Kidney Clock in Hypertension"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Aalim Weljie (University of Pennsylvania, USA)
"Oncogenic MYC Disrupts Circadian Oscillation and Induces a Novel Ultradian Metabolic Profile"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rhythms of Life and Lifespan: Circadian Physiology and Aging
Discussion Leader: Joke Meijer (Leiden University Medical Center, The Netherlands)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Salvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"Altered Pattern of Circadian Gene Expression with Age"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Garret FitzGerald (University of Pennsylvania, USA)
"The Human Physiological Chronobiome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jaga Giebultowicz (Oregon State University, USA)
"Molecular Signatures of Circadian Aging"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Art Petronis (University of Toronto / Centre for Addiction and Mental Health (CAMH), Canada)
"Circadian Epigenetic Hallmarks of Aging and Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Entrainment and Plasticity
of Circadian Networks
Discussion Leader: Jennifer Loros (Geisel School of Medicine, Dartmouth College, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Samer Hattar (National Institutes of Health, USA)
"Light Affects Mood and Learning Through Parallel Brain Circuits"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Guy Bloch (The Hebrew University of Jerusalem, Israel)
"Circadian Plasticity in Honey Bees"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Martha Merrow (Ludwig Maximilian University of Munich, Germany)
"Entrainment Characteristics Throughout the Circadian System - From Molecule to Cell to Organism"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Elzbieta Pyza (Jagiellonian University, Poland)
"Circadian Plasticity of Synapses, Neurons and Glial Cells"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Francois Rouyer (University of Paris-Saclay, France)
"Synchronization and Reorganization of the Brain Circadian Network by Visual Inputs"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Luis Larrondo (Pontificia Universidad Catolica de Chile, Chile)
"Synthetic Oscillators, Live Images and Clock-Based Eidetic Memory"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jeffrey Swan (University of California, Santa Cruz, USA)
"Mechanisms of Output Signaling in the Cyanobacterial Clock"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics of Sleep
Discussion Leader: Leslie Griffith (Brandeis University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Kyunghee Koh (Thomas Jefferson University, USA)
"Genes and Neural Circuits Regulating Sleep in Drosophila "
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Ketema Paul (Morehouse School of Medicine, USA)
"Effects of Peripheral Clocks on Sleep"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Dragana Rogulja (Harvard University, USA)
"Why Is Sleep Essential?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Michael Young (Rockefeller University, USA)
"Molecular Basis of Delayed Sleep Phase Syndrome"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Oscillations in Circadian
Circuits
Discussion Leader: Ravi Allada (Northwestern University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Erik Herzog (Washington University in St. Louis, USA)
"Clock Stars: Roles for Astrocytes in Circadian Timing"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Michael Hastings (MRC Laboratory of Molecular Biology, United Kingdom)
"Clock Stars: Shining Light on Mechanisms"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andrea Meredith (University of Maryland School of Medicine, USA)
"Big Time for BK: Integrative Mechanisms Driving Circadian Patterning of SCN Neuronal Activity"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Michael Rosbash (Brandeis University, USA)
"Cellular Basis of Rest: Activity Rhythms in Drosophila "
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Xitong Liang (Washington University, USA)
"A Series of Suppressive Signals Within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
Jennifer Evans (Marquette University, USA)
"Circuit Mechanisms of the SCN Network"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Eric Bittman (University of Massachusetts, USA)
"There's More than One Way to Speed up a Hamster Clock: An Update on Duper"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Adaptation
and Maladaptation: Rhythms Under Normal and Pathological Conditions
Discussion Leader: Till Roenneberg (Ludwig Maximilian University of Munich, Germany)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
Sarah Geiger (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Feeding Immunity: The Regulation of Circadian Immune Responses by Mealtimes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Satchidananda Panda (Salk Institute for Biological Studies, USA)
"Molecular Changes Underlying Adaptation to Diurnal Feeding-Fasting Rhythms"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Richa Saxena (Harvard Medical School / Massachusetts General Hospital, USA)
"Genetic Underpinnings of Circadian Variations in Humans"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Han Wang (Soochow University, China)
"Circadian Modulation of Major Depressive Disorder (MDD)"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure