Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Advances in Sleep and Circadian Research
Discussion Leader: Phyllis Zee (Northwestern University, United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
Charles Bourque (Research Institute McGill University Health Centre, Canada)
"Multimodal Non-Photic Inputs to the Suprachiasmatic Nucleus in Mice"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Mimi Shirasu-Hiza (Columbia University, United States)
"How to Eat More, Lose Fat, and Live Longer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Carla Green (University of Texas Southwestern Medical Center, United States)
"Time Matters: Circadian Control of Metabolism"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Dylan Ma (Brandeis University, United States)
"Novel Clock Neuron Subtypes Regulate Temporal Aspects of Sleep"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Clock Outputs
Discussion Leader: Till Roenneberg (LMU Munich, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Kenneth Wright (University of Colorado Boulder, United States)
"Circadian and Sleep Disruption and the Microbiome"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Horacio de la Iglesia (University of Washington, United States)
"How The Sun and The Moon Time Our Sleep"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Valerie Mongrain (Université de Montréal, Canada)
"The Electrophysiological and Transcriptomic Responses to an Alkaloid Sleep Inducer are Shaped by Clock Time"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jennifer Hurley (Rensselaer Polytechnic Institute, United States)
"Disordered Proteoforms in the Negative Arm of the Clock Regulate Interactomes to Control Circadian Temperature Responses"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Dragana Rogulja (Harvard University, United States)
"Temperature and Time"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Lamya Ghenim (Commissariat à l'énergie atomique et aux énergies alternatives Grenoble , France)
"A new Ultradian Rhythm in Mammalian Cell Dry Mass Observed by Holography"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Eva Herrero Serrano (University of Cambridge, United Kingdom)
"TLWD Scaffold Proteins Sustain Sircadian Function in Arabidopsis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elizabeth Klerman (Mass General Hospital/Brigham and Women's Hospital / Harvard Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Discoveries from Across the Phylogenetic Tree
Discussion Leader: Charalambos Kyriacou (University of Leicester, United Kingdom)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Martha Merrow (LMU Munich, Germany)
"Circadian Clocks in the Non-Photosynthetic Bacteria"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Robert Lucas (University of Manchester, United Kingdom)
"Moving on from Lux to Facilitate Cross-Species Comparisons of Photosensitivity"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Takato Imaizumi (University of Washington, United States)
"Photoperiodic Measurement Mechanisms in Plants"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Alex Keene (Texas A&M University, United States)
"The Evolution of Sleep Loss in Cavefish"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Circadian Photoentrainment
Discussion Leader: Kathleen Merikangas (National Institute of Mental Health, Intramural Research Program, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Tiffany Schmidt (Northwestern University, United States)
"Genetic Underpinnings of ipRGC Diversity"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Takashi Yoshimura (Nagoya University, Japan)
"Towards Understanding Molecular Bases of Infradian Rhythms"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Sujata Rao (Cleveland Clinic, United States)
"A novel Role for Melanopsin Signaling in Diurnal Photoreceptor Phagocytosis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Susan Golden (University of California, San Diego, United States)
"Watching the Gears of the Circadian Clock Reset in Real Time"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Kristin Tessmar-Raible (Max Perutz Labs , University of Vienna, Austria/ AWI, Germany, Austria)
"Timing Physiology and Behavior by the Moon"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Wanhe Li (Texas A&M University, United States)
"A Genetic Model for Understanding the Timekeeping Mechanism During Chronic Social Isolation"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Maria Luísa Jabbur (7221 Highway 70S, United States)
"Do Bacteria Care About the Seasons? Evidence of Photoperiodic Time-Measurement in Cyanobacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Circadian Clocks in Microbes
Discussion Leader: Carl Johnson (Vanderbilt University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Sarah Reece (University of Edinburgh, United Kingdom)
"Punctual Parasites: Why Rhythmic Replication is Advantageous for Malaria Parasites"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Chelsea Powell (Harvard Medical School, United States)
"Gut Microbially Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Helene Borrmann (University of Oxford, United Kingdom)
"Circadian Regulation of Viruses"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christoph Scheiermann (University of Geneva, Switzerland)
"Circadian Anti-Tumor Immune Responses"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Core Clock Mechanisms
Discussion Leader: Michael Rosbash (Brandeis University / Howard Hughes Medical Institute, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Achim Kramer (Charité - Universitätsmedizin Berlin, Germany)
"The Cell Biology of the Circadian Clock in Mammals"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
María Ceriani (Fundación Instituto Leloir- IIBBA-CONICET, Argentina)
"Remodeling of Circadian Pacemaker Projections, Not Merely a Neuronal Tale"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Priya Crosby (University of California, Santa Cruz, United States)
"Cooperativity and Competition in CLOCK:BMAL1 Regulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Joanna Chiu (University of California, Davis, United States)
"Nutrient-Dependent Regulation of Biological Rhythms"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Katja Lamia (Scripps Research, United States)
"BMAL1-HIF2a Heterodimers Contribute to Renal Cancer Growth"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Melissa Richardson (Oakwood University, United States)
"Divided and Conquered: Fragmenting the Day-Night Cycle Negatively Impacts Circadian Rhythms, Mood, and Development in Mice"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Shixuan Liu (Stanford University, United States)
"A Non-Human Primate Model to Study Circannual Rhythm"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clocks Role in Diseases
Discussion Leader: Erik Herzog (Washington University in St. Louis, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Miho Sato (University of Zurich, Switzerland)
"Development of the Circadian Rhythm"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Selma Masri (University of California, Irvine, United States)
"Dissecting the Role of the Circadian Clock in Cancer"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Karen Gamble (University of Alabama at Birmingham, United States)
"A Novel Role for Endothelin B Receptors in High Salt Diet-Induced Circadian Disruption"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Luoying Zhang (Huazhong University of Science & Technology, China)
"Human Period3 Variants Lead to Winter Depression-Like Phenotypes Via Glucocorticoid and Serotonin"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Clock Circuits and Connectivity
Discussion Leader: Joseph Takahashi (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Jennifer Evans (Marquette University, United States)
"Sex Differences in Central Clock Circuits Controlling Daily Rhythms"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Maria de la Paz Fernandez (Barnard College, United States)
"Sex Differences in the Drosophila Circadian Clock Neuron Network"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Jeff Jones (Texas A&M University, United States)
"Ins and Outs of Circadian Time"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lauren Hablitz (University of Rochester, United States)
"The Glymphatic System as a Target for Circadian Entrainment?"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Andrew Liu (University of Florida College of Medicine, United States)
"Circadian Sleep/Wake Dysregulation in Neurodevelopmental Disorders"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Anna-Marie Finger (University of California San Francisco & Charite University Medicine Berlin, United States)
"Defining the Role of TGF-beta Signaling for Intercellular Coupling and Circadian Entrainment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Andrew Beale (MRC Laboratory of Molecular Biology, United Kingdom)
"Differential Temperature Sensitivity of Protein Synthesis Drives the Mammalian Nocturnal-Diurnal Switch"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Clocks in Physiology and Metabolism
Discussion Leader: Amita Sehgal (University of Pennsylvania, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Stacey Harmer (University of California, Davis, United States)
"Circadian Control of Floret Development in Sunflower"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Megumi Hatori (Nagoya University, Japan)
"Time Restricted Feeding in Mammals Including Non-Human Primates"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Richa Saxena (Mass General Hospital/ Harvard Medical School, United States)
"Melatonin Receptor 1b Variation, Chronotype and Glucose Metabolism"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Julie Pendergast (University of Kentucky, United States)
"Circadian Regulation of Metabolic Risk in Mice and Women"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure