SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Generation and Control of Ciliary Movement |
| Discussion Leaders: Mary Porter (University of Minnesota); Pinfen Yang (Marquette University) |
7:35 pm - 7:45 pm | Mary Porter (University of Minnesota) "Introduction" |
7:45 pm - 8:05 pm | Stephen King (University of Connecticut)
"Structure and regulation of axonemal dyneins" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | David Mitchell (SUNY Upstate Medical University, NY)
"New insights into axonemal dynein assembly" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Elizabeth Smith (Dartmouth College)
"Regulation of axonemal dynein is mediated by a calmodulin and radial spoke associated complex" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jonathan Howard (Max Planck Institute, Germany)
"How sliding-controlled molecular motors and basal properties shape the flagellar beat" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Basal Bodies, Cilia Assembly and Intraflagellar Transport (IFT) |
| Discussion Leaders: Lynne Quarmby (Simon Fraser University, Burnaby, Canada); Cynthia Jensen (University of Auckland) |
9:00 am - 9:05 am | Lynne Quarmby (Simon Fraser University, Burnaby, Canada) "Introduction to basal bodies and cilia assembly" |
9:05 am - 9:25 am | Susan Dutcher (Washington University, St. Louis)
"Two hybrid screens for basal body genes" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Tomer Avidor-Reiss (Harvard Medical School)
"Cilium inheritance and formation - the fly standpoint" |
9:45 am - 9:50 am | Discussion |
9:50 am | Coffee Break |
10:10 am - 10:30 am | Douglas Cole (University of Idaho)
"Molecular architecture of the IFT particle" |
10:30 am - 10:35 am | Discussion |
10:35 am - 10:55 am | Nedra Wilson (Oklahoma State University)
"Regulation of ciliary assembly and length control" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Group Photo |
11:30 am - 11:35 am | Cynthia Jensen (University of Auckland) "Introduction to sensory and primary cilia" |
11:35 am - 11:55 am | Jon Scholey (University of California at Davis)
"Kinesin-2 motors and sensory cilium biogenesis in C. elegans neurons" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Gregory Pazour (University of Massachusetts)
"IFT targeting of membrane proteins to the mammalian cilium" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I: Cilia and Ciliary Structure and Function |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Primary Ciliary Dyskinesia (PCD) and Diseases of the Cilium |
| Discussion Leaders: Serge Amselem (INSERM u. 654 Creteil, France); Michel Leroux (Simon Fraser University) Introduction |
7:30 pm - 7:35 pm | Serge Amselem (INSERM u. 654 Creteil, France) Introduction |
7:35 pm - 7:55 pm | Nobutaka Hirokawa (University of Tokyo, Japan)
"Cilia, KIF3 motor, nodal flow, and left-right determination" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Martin Blum (University of Hohenheim, Stuttgart, Germany)
"A cilia-driven leftward flow specifies laterality upstream of asymmetric nodal signaling in the frog Xenopus laevis" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Heymut Omran (University of Freiburg, Germany)
"Novel molecular insights in PCD" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Friedhelm Hildebrandt (University of Michigan)
"Cilia and cystic kidney disease" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Max Nachury (Genentech)
"A core complex of conserved BBS proteins links phosphoinositide signaling to primary cilium biogenesis" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mucins and Mucus: Gene and Epigenetic Regulation |
| Discussion Leaders: Judith Voynow (Duke University); Sandra Gendler (Mayo Clinic, Scottsdale) |
9:00 am - 9:25 am | Dallas Swallow (University College, London)
"Polymorphic cis-regulation of MUC gene expression" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Yin Chen (CIIT Centers for Health Research, RTP, NC)
"MUC19; complete genomic structure and its function beyond mucociliary clearance" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Peter Koo (MD Anderson Cancer Center)
"CREB, a key regulator of mucin gene expression" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Artem Loukoianov (University of California at Davis)
"Epigenetic regulation of airway mucin gene expression" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Peter Di (University of Pittsburgh)
"Transcriptional regulation of cigarette smoke-induced MUC5AC expression in airway epithelium" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Shuo Zheng (Duke University)
"Neutrophil elastase increases MUC5AC mucin mRNA via the polyA signal in the 3'- untranslated region" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I: Cilia and Ciliary Structure and Function |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mucins and Mucus: Disease |
| Discussion Leaders: Scott Randell (University of North Carolina); Kenneth Adler (North Carolina State University) |
7:30 pm - 7:55 pm | Mary Rose (Children's Research Institute, Washington DC)
"Glucocorticoid-induced repression of basal and induced MUC5AC expression in airway epithelial cells" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Olivera Finn (University of Pittsburgh)
"MUC1 as an immunogen for anti-cancer antibodies" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Anna Velcich (Albert Einstein / Montefiore Cancer Center, NY)
"Muc2 depletion and risk of gastrointestinal cancer development" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Kermit Carraway (University of Miami)
"MUC4 function and regulation" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mucins and Mucus: Development and Secretion |
| Discussion Leaders: Burton Dickey (MD Anderson Cancer Center); John Sheehan (University of North Carolina) |
9:00 am - 9:25 am | Anand Patel (Washington University, St. Louis)
"CLCA gene clusters control mucous cell metaplasia" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Christopher Evans (MD Anderson Cancer Center)
"Origins of goblet cell development and hyperplasia" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | David Erle (University of California, San Francisco)
"IL-13 and EGFR signaling" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Duncan Rogers (Imperial College, London)
"Function of goblet cells in mucin secretion" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Yohannes Tesfaigzi (Lovelace Respiratory Research Institute)
"IFNgamma-induced cell death in airway epithelium: role of Bik-mediated ERK activation" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | YunXiang Zhu (University of North Carolina)
"Munc13-2 knockout mouse reveals Clara cells as natural mucin-secreting cells" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II: Mucus, Lining Fluid and Mucociliary Clearance |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mucins and Mucus: Intracellular Signaling |
| Discussion Leaders: Reen Wu (University of California at Davis); C. William Davis (University of North Carolina) |
7:30 pm - 7:55 pm | Bernard Fischer (Duke University)
"Oxidant regulation of mucin gene expression in airway inflammation" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Jin-Ah Park (North Carolina State University)
"Role of PKC delta in airway mucin secretion" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Kwang Chul Kim (Lovelace Respiratory Research Institute)
"Anti-inflammatory role of MUC1 in mucin during airway bacterial infection" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Anurag Agrawal (Baylor)
"Excess mucus contribution to airway obstruction in a mouse model of asthma" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | Modeling of the System and its Components |
| Discussion Leaders: Richard Superfine (University of North Carolina); Matthias Salathe (University if Miami) |
9:00 am - 9:25 am | Patrick Sears (University of North Carolina)
"Empirical model of ciliary dynamics for normal and PCD human airway epithelium" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | John Sheehan (University of North Carolina)
"Mucus: its composition and relation to rheology" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Richard Superfine (University of North Carolina)
"The virtual lung" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:45 am - 11:05 am | Sorin Mitran (University of North Carolina)
"Models of mucociliary clearance I: fluid-structure interactions" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Jaro Ricka (University of Bern, Switzerland)
"Models of mucociliary clearance II: functional imaging of mucociliary phenomena. Do the models work?" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Michael Rubenstein (University of North Carolina)
"Models of mucociliary clearance III: Molecular model of periciliary layer - mucus interactions" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II: Mucus, Lining Fluid and Mucociliary Clearance |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Airway Surface Liquid and Periciliary Fluid |
| Discussion Leaders: Richard Boucher (University of North Carolina); Marcus Mall (University of Heidelberg) |
7:30 pm - 7:55 pm | Robert Tarran (University of North Carolina)
"Proteomic and functional characterization of a pH-sensitive soluble protein regulator of airway surface liquid volume" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | George Caughey (University of California - San Francisco)
"Regulation of epithelial sodium transport by peptidases" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jeffrey Wine (Stanford University)
"Origins and properties of mucus in healthy and cystic fibrosis airways" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Steven Ballard (University of South Alabama)
"Airway surface liquid in disease" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |