SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | I. Prospects and Themes |
7:40 pm - 7:45 pm | Discussion Leaders: Win Sale (Emory University School of Medicine, Atlanta, GA) and Burton Dickey (MD Anderson Cancer Ctr, Houston TX) "Introduction" |
7:45 pm - 8:25 pm | Peter Satir (Albert Einstein College of Medicine, Bronx, NY)
"40 years after the sliding-microtubule model for ciliary movement: Prospects for the next 40 years" |
8:25 pm - 8:35 pm | Discussion |
8:40 pm - 9:20 pm | Richard Boucher (University of North Carolina, Chapel Hill, NC)
"Mucus, cilia, mucociliary clearance and airway diseases" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | II. Development I - Morphogenesis and Differentiation |
9:00 am - 9:05 am | Discussion Leaders: Peter K.
Jackson (Genentech, Inc., South San Francisco, CA) and Bill Snell (Univ. Texas Southwestern Medical Center, Dallas, TX) "Introduction" |
9:05 am - 9:25 am | Brian Mitchell (Northwestern University, Evanston, IL)
"Planar cell polarity of cilia in the development of ciliated epithelia" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Kimberly McDermott (UCSF, San Francisco, CA)
"Role of cilia in branching morphogenesis during lung development" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Tamara Caspary (Emory University School of Med., Atlanta, GA)
"Cilia and sonic hedgehog signaling" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break / Group Photo |
10:55 am - 11:05 am | Benedicte Durand (University of Lyon, France)
"Novel functions of primary cilia during mouse lung development" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:15 am | Discussion Leaders: Peter K.
Jackson (Genentech, Inc., South San Francisco, CA) and Bill Snell (Univ. Texas Southwestern Medical Center, Dallas, TX) "Introduction" |
11:15 am - 11:35 am | Jeff Whitsett (Children's Hospital Medical Center, Cincinnati, Ohio)
"Induction of goblet cell hyperplasia in the airway epithelium" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Anand Patel (Washington University School of Medicine, St. Louis, MO)
"Molecular mechanism for hCLCA1 regulation of mucous cell metaplasia" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Yohannes Tesfaigzi (Lovelace Institute, Albuquerque, NM)
"Resolution of mucous cell metaplasia" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session A (first viewing) |
5:30 pm - 7:30 pm | III. Signaling and transcriptional control of cilia and mucins |
5:30 pm - 5:35 pm | Discussion Leaders: Steven L. Brody (Washington University Sch. Med., St. Louis MO) and Mary C. Rose (Children's National Medical Center, Washington D.C.) "Introduction" |
5:35 pm - 5:55 pm | Dave W. Burt (Roslin Institute (Edinburgh), Roslin, Midlothian, UK)
"A genetic analysis of Hedgehog signaling in the chicken embryo" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Soeren Christensen (Institute for Molecular Biology and Physiology, University of Copenhagen, Denmark)
"The PDGFRαα signaling pathway in cilia" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Christopher M. Evans (The University of Texas M. D. Anderson Cancer Center, Houston, TX)
"Function and control of Muc5ac gene expression in murine airways" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | Mary Chang (University of California, Davis)
"Regulation of MUC5B gene expression in the airways" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:55 am | IV. Fundamental Processes in Cilia and Mucus I |
| A. Centrioles and Ciliary Assembly |
9:00 am - 9:05 am | Discussion Leader: Michel Bornens (Institut Curie, CNRS, Paris France) "Introduction" |
9:05 am - 9:25 am | Juliette Azimzadeh (UCSF, San Francisco, CA)
"Basal body assembly and orientation: Planaria as a model for the airway" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Masafumi Hirono (University of Tokyo, Tokyo, Japan)
"Building a centriole" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Michael McGuckin (Mater Medical Research Institute, Brisbane, Australia)
"Aberrant assembly of a secreted mucin leads to spontaneous inflammation" |
10:25 am - 10:35 am | Discussion |
10:35 am - 10:55 am | Coffee Break |
10:55 am - 12:30 pm | IV. Fundamental Processes in Cilia and Mucus I |
| B. Mucin Secretion |
10:55 am - 11:00 am | Discussion Leader: Yohannes Tesfaigzi (Lovelace Institute, Albuquerque, NM) "Introduction" |
11:00 am - 11:20 am | Burton Dickey (M.D. Anderson Cancer Center, Houston, TX)
"Structure and function of the airway secretory cell exocytic machinery" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | C. William Davis (University of North Carolina, Chapel Hill, NC)
"Signal transduction pathways controlling mucin secretion" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Eduardo Lazarowski (University of North Carolina, Chapel Hill, NC)
"Coordinated release of nucleotides and mucin from human airway epithelial cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session A (second viewing) |
5:30 pm - 7:30 pm | V. Fundamental Processes in Cilia and Mucus II |
5:30 pm - 5:35 pm | Discussion Leaders: Sandra Gendler (Mayo Clinic College of Medicine, Scottsdale, AZ) and Susan K. Dutcher (Washington University School of Medicine, St. Louis, MO) "Introduction" |
5:35 pm - 5:55 pm | Tim Stearns (Stanford University, Stanford, CA)
"Ciliogenesis in ciliated epithelial cells" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Monica Bettencourt-Dias (Gulbenkian Institute, Portugal)
"Control of Centrosome assembly" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | K. Chul Kim (Lovelace Respiratory Research Institute, Albuquerque, NM)
"Epithelial barrier to infection: anti-inflammatory role of MUC1 mucin" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | Gunnar C. Hansson (University of Gothenburg, Sweden)
"Organization of the mucus in the large intestine with implications for the respiratory tract" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VI. Cilia, Mucus and Disease I |
9:00 am - 9:05 am | Discussion Leaders: John Fahy (UCSF, San Francisco, CA) and Larry Ostrowski (Univ. North Carolina, Chapel Hill, NC) "Introduction" |
9:05 am - 9:25 am | Heymut Omran (University Hospital Freiburg, Freiburg, Germany)
"Cilia defects and ciliopathies" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Serge Amselem (Institut National de la Santé et de la Recherche Médicale, Unité 654, Créteil, France)
"A novel PCD gene identifies a new class of ciliopathy proteins" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Michael J. Welsh (Howard Hughes Medical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA)
"Role of Bardet-Biedl syndrome proteins in airway cilia" |
10:25 am - 10:35 am | Discussion |
10:35 am - 10:55 am | Coffee Break |
10:55 am - 11:00 am | Discussion Leaders: John Fahy (UCSF, San Francisco, CA) and Larry Ostrowski (Univ. North Carolina, Chapel Hill, NC) "Introduction" |
11:00 am - 11:20 am | Rosanna M. Forteza (University of Miami School of Medicine, FL)
"Hyaluronan depolymerization at apical surfaces during airway inflammation upregulates mucin gene expression" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | David Thornton (University of Manchester, England)
"Structure and function of polymeric mucins in airway mucus in health and disease" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Judith Voynow (Duke University Medical Center, Durham, NC)
"Mechanisms of mucin overproduction in neutrophil-dominated airway diseases" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session B (first viewing) |
5:30 pm - 7:30 pm | VII. Cilia, Mucus and Disease II |
5:30 pm - 5:35 pm | Discussion Leader: Martina Brueckner (Yale University, New Haven, CT) "Introduction" |
5:35 pm - 5:55 pm | Michael R. Knowles (Univ. North Carolina, Chapel Hill, NC)
"Genetic causes of primary ciliary dyskinesia (PCD)" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Cecilia Lo (NHLBI, NIH, Bethesda, MD)
"A central role for the cilium in congenital heart disease" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Ilene K. Gipson (Schepens Eye Research Institute, Boston, MA)
"Mucins and ocular disease" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | Duncan Rodgers (Imperial College, London)
"Mucoactive agents for mucus hypersecretory airway diseases" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next co-Vice Chairs; fill out Conference Evaluation Forms; discuss future site & scheduling preferences; election of the next co-Vice Chairs) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VIII. Mechanism and Control of Ciliary Motility |
9:00 am - 9:05 am | Discussion Leaders: David R. Mitchell (SUNY, Syracuse, NY) and Ritsu Kamiya (University of Tokyo) "Introduction" |
9:05 am - 9:25 am | Daniela Nicastro (Brandeis University, Waltham, MA)
"Cryoelectron tomography and a structural basis for ciliary motility" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Maureen Wirschell (Emory University School of Medicine, Atlanta, GA)
"Regulation of ciliary motility by the conserved I1 inner arm dynein" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Elizabeth F. Smith (Dartmouth College, Hanover, NH)
"Calcium regulation of ciliary motility: role of the central pair/radial spokes" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Kent L. Hill (UCLA, Los Angeles, CA)
"Identification of a new DRC subunit and structure-function analysis of dynein regulatory proteins in Trypanosoma brucei" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Matthias Salathe (University of Miami, Miami, FL)
"Soluble adenylyl cyclase in airway epithelial cells is an axonemal protein that mediates ciliary beat frequency response to changes in CO2/HCO" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Stephen M. King (Univ. Connecticut Health Center, Farmington, CT)
"Schmidtea mediterranea: a model system for analysis of motile cilia" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Gaia Pigino (University of Siena, Italy)
"Electron tomographic analysis of intraflagellar transport complexes in situ" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Karl Lechtreck (Univ. Massachusetts Medical Center, Worcester, MA)
"Mutations in Bardet-Biedl syndrome genes impair phototactic steering in Chlamydomonas" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session B (second viewing) |
5:30 pm - 7:30 pm | IX. Mucociliary Interactions |
5:30 pm - 5:35 pm | Discussion Leaders: Joseph H. Sisson (University of Nebraska Medical Center, Omaha, NE) and Richard Cone (Johns Hopkins University, Baltimore, MD) "Introduction" |
5:35 pm - 5:55 pm | Marcus A. Mall (University of Heidelberg, Germany)
"Role of cilia, mucus and airway surface liquid in mucociliary dysfunction: lessons from mouse models" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | John Sheehan (University of North Carolina, Chapel Hill, NC)
"The airway mucus transport apparatus: Interactions of N-terminal domains of secreted mucins with cilia" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Michael Rubenstein (University of North Carolina, Chapel Hill, NC)
"Mucoadhesion" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | Justin Hanes (Johns Hopkins University, Baltimore, MD)
"Particle transport in mucus" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |