SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Towards Integrating Cilia, Mucins, and Mucociliary interactions: Prospects and Themes |
| Discussion Leaders: Peter Satir (Albert Einstein) and Sandra Gendler (Mayo Clinic, Phoenix) |
7:35 pm - 7:40 pm | Peter Satir (Albert Einstein) and Sandra Gendler (Mayo Clinic, Phoenix) "Introduction" |
7:40 pm - 8:05 pm | Gregory J. Pazour (Univ. Mass.) "Motile and primary cilia in biology and disease" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | David Thornton (Univ. of Manchester, UK) "From mucins to mucus" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Richard Boucher (Univ. of North Carolina, Chapel Hill) "Mucociliary interactions: views from the respiratory tract" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Development of Cilia and of Secretory Cells |
| Discussion Leaders: Mary Porter (Univ. Minnesota, Minneapolis) and Burton Dickey (MD Anderson Cancer Ctr, Houston) |
9:00 am - 9:05 am | Mary Porter (Univ. Minnesota, Minneapolis) "Introduction - cilia and development" |
9:05 am - 9:25 am | Christopher Kintner (Salk Institute, La Jolla)
"Developmental signals specify different cilia subtypes in Xenopus" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Eszter K. Vladar (Stanford)
"Planar Cell Polarity Orients Respiratory Cilia" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Group Photo / Coffee Break |
10:25 am - 10:45 am | Steven Brody (Washington Univ., St. Louis) "Relationships between primary and motile ciliogenesis in developing and injured airway epithelium" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:00 am | Burton Dickey (MD Anderson Cancer Ctr) "Introduction - secretory cells and development" |
11:00 am - 11:20 am | Wellington Cardoso (Boston Univ.) "Notch signaling modulates the balance between ciliated and secretory cells" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jeffrey Whitsett (Cincinnati Children’s Hospital) "Transcriptional regulation of goblet cell differentiation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Scott Randell (Univ. North Carolina, Chapel Hill) "Micro RNA regulation of human airway epithelial phenotypes" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A (1st viewing) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling and regulation in Cilia and Mucins |
| Discussion Leaders: Susan Dutcher (Washington Univ., St. Louis) and Yin Chen (University of Arizona) |
7:30 pm - 7:35 pm | Susan Dutcher (Washington Univ., St. Louis) and Yin Chen (University of Arizona) "Introduction" |
7:35 pm - 7:55 pm | Wallace Marshall (Univ. CA, San Francisco) "Ciliary Length Control Systems" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Zhaoxia Sun (Yale Univ.) "Cilia in the TSC/mTOR pathway" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Christopher Evans (MD Anderson Cancer Center, Houston) "Life (and Death) without Muc5ac and Muc5b in murine airways" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Isabelle Van Seuningen (Inserm, Lille, France) "Epigenetic regulation of mucin genes: a new family of biomarkers in lung cancers" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Fundamental Processes: Mucins and Cilia |
| Discussion Leaders: K.C. Kim (Temple Univ.) and Maureen WIrschell (Emory) |
9:00 am - 9:05 am | K.C. Kim (Temple Univ.) "Introduction - Mucins" |
9:05 am - 9:25 am | Bradley Schroeder (Univ. CA, San Francisco) "Specialized ER proteins with critical roles in mucin production" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Mehmet Kesimer (Univ. North Carolina, Chapel Hill) "Unfolding a secreted mucin" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:45 am | Gunnar C. Hansson (Univ. Gothenburg, Sweden) "Intestinal mucin function and organization in relation to CFTR and the respiratory tract" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:00 am | Maureen Wirschell (Emory) "Introduction - Cilia" |
11:00 am - 11:20 am | Winfield Sale (Emory Univ.) "Regulation of cilia function in Chlamydomonas" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Elizabeth Smith (Dartmouth College)
"Calcium and regulation of ciliary motility" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Rebecca Burdine (Princeton)
"Cilia structure and function in zebrafish development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A (2nd viewing) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic Approaches in Ciliopathies and Mucociliary Diseases |
| Discussion Leaders: Heymut Omran (Univ. Freiburg) and Judith Voynow (Duke Univ.) |
7:30 pm - 7:35 pm | Heymut Omran (Univ. Freiburg) and Judith Voynow (Duke Univ.) "Introduction" |
7:35 pm - 7:55 pm | Khalid Fakhro (Yale Univ.) "Genetics of human heterotaxy" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Philip L. Beales (University College, London) "Craniofacial and skeletal patterning in ciliopathies" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Maimoona Zariwala (Univ. North Carolina, Chapel Hill) "Use of Whole-Exome Sequencing to Define Genetic Causes of Primary Ciliary Dyskinesia" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | David Schwartz (National Jewish Health, Denver) "Genetic studies implicate MUC5B in idiopathic pulmonary fibrosis" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mucociliary Diseases, Submucosal Glands and Mucus |
| Discussion Leaders: Judith Voynow (Duke Univ.) and Stephen Ballard (Univ. South Alabama) |
9:00 am - 9:05 am | Judith Voynow (Duke) "Introduction - models of mucociliary diseases" |
9:05 am - 9:25 am | Larry Ostrowski (Univ. North Carolina, Chapel Hill) "Pathogenesis and Treatment of Primary Ciliary Dyskinesia in a novel mouse model" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Michael Welsh (Univ. Iowa) "Airway alterations in the CF pig model" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:45 am | John Engelhardt (Univ. Iowa) "Airway alterations in the CF ferret model" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:00 am | Stephen Ballard (Univ. South Alabama) "Introduction - Submucosal glands and mucus" |
11:00 am - 11:20 am | Jeff Wine (Stanford Univ.) "Submucosal Glands, Mucus, and Cystic Fibrosis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Walter Finkbeiner (UCSF) "Characterization of Native and Cultured Human Tracheobronchial Gland Serous and Mucous Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Silvia Kreda (UNC) "Rho signaling and VAMP8 are important mediators of airway goblet cell mucin secretion" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Ken Adler (North Carolina State Univ.) "Circumvention of mucin hypersecretion by peptide inhibition" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B (1st viewing) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Structure-Function Interactions in Cilia and Mucus |
| Discussion Leaders: Stephen King (Univ. Conn) and C.W. Davis (Univ. North Carolina, Chapel Hill) |
7:30 pm - 7:50 pm | Daniela Nicastro (Brandeis Univ.) "CryoEM tomography: The axonemal dynein regulatory complex and nexin link" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Mary Porter (U. Minnesota)
"Conserved subunits required for assembly of the nexin-DRC link and regulated microtubule sliding" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Chris O'Callaghan (Univ. Leicester, UK)
"The interaction of cilia with pathogens" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Diego Preciado (Children's National, Washington DC)
"Bacterial Lysate Induction of Cxcl2 and Middle Ear Mucosal Metaplasia in Mice" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Richard Cone (Johns Hopkins Univ.)
"Barrier properties of mucus" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mucociliary Interactions |
| Discussion Leaders: Justin Hanes (Johns Hopkins Univ.) and Michael Rubinstein (Univ. N. Carolina, Chapel Hill) |
9:00 am - 9:05 am | Justin Hanes (Johns Hopkins Univ.) "Introduction to Mucus Fundamentals" |
9:05 am - 9:15 am | Ying-Ying Wang (Johns Hopkins University) "Muco-inert nanoparticles reveal highly conserved microstructure of human mucus across entire physiological pH range" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:40 am | John Fahy (Univ. CA, San Francisco) "Mechanisms of pathologic mucus formation in airway disease: roles for proteases and lectins" |
9:40 am - 9:50 am | Discussion |
9:50 - 10:10 am | Paul Quinton (Univ. CA, San Diego) "A new intersection of electrolytes and mucus" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:45 am | Michael Rubinstein (Univ. N. Carolina, Chapel Hill) "Introduction to Mucus Interactions with Cilia" |
10:45 am - 10:55 am | Liheng Cai (Univ N.Carolina, Chapel Hill) "New Insights on the Structure of Periciliary Layers of Lungs" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Susan Suarez (Cornell Univ.) "Sperm interactions with mucus and cilia" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Panteleimon Rompolas (Univ. Conn.) "Planarians as a molecular genetic system for analyzing cilia and force production against secreted mucus" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Richard Superfine (Univ. North Carolina, Chapel Hill) "Modeling mucociliary interactions for the generation of flow" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B (2nd viewing) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Life at the Interface: Cilia and Fluid Interactions |
| Discussion Leader: Martina Brueckner (Yale Univ. New Haven) |
7:30 pm - 7:35 pm | Martina Brueckner (Yale Univ., New Haven) "Introduction" |
7:35 pm - 7:55 pm | Hiroshi Hamada (Osaka Univ., Japan) "Fluid dynamics at the node, left-right development" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Iain Drummond (Harvard Univ.) "Fluid movement in the developing kidney" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Sergio Gradilone (Mayo Clinic, Rochester) "Cholangiocyte primary cilia: Key sensory organelles in biliary tree fluid" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Matthias Salathe (Univ. Miami) "New paradigms for regulation of ciliary function by secretions" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |