SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Talks on Cilia and Mucus |
| Discussion Leaders: Martina Brueckner (Yale University School of Medicine) and David Thornton (University of Manchester)
|
7:40 pm - 8:20 pm | George Witman (University of Massachusetts Medical School)
"Cilia Assembly and Function"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Jeffrey Wine (Stanford University School of Medicine)
"Mucus, Secretion and Cystic Fibrosis"
|
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ciliary Assembly and Mucus Production |
| Discussion Leader: Winfield Sale (Emory University School of Medicine) and Mary Rose (Children's National Medical Center)
|
9:00 am - 9:20 am | Eszter Vladar (Stanford University School of Medicine)
"Centriole Assembly"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | David Erle (University of California San Francisco)
"Intracellular Assembly of Mucins"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Esben Lorentzen (Max Planck Institute, Martinsried)
"Structural Mechanisms of Ciliary Assemby"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
11:00 am - 11:20 am | C. William Davis (University of North Carolina, Chapel Hill)
"Mucus Secretion and Synthesis: Regulated versus Basal Pathways"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Elizabeth Smith (Dartmouth College)
"Ciliary Motility"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Michael McGuckin (University of Queensland)
"Cytokines, Inflammation and Mucus Production"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Biophysics of Cilia/Mucus Interactions |
| Discussion Leader: Stephen King (University of Connecticut Health Center) and Richard Superfine (University of North Carolina, Chapel Hill)
|
5:30 pm - 5:50 pm | Hiroaki Ishikawa (University of California, San Francisco)
"Primary Cilia Respond to Uniaxial Strain by Reorienting and Elongating Along the Axis of Stretch" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Richard Cone (John's Hopkins University)
"Biophysics of Mucus"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Brian Button (University of North Carolina, Chapel Hill)
"Mucin Effects on the Peri-ciliary Layer"
|
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Julien Vermot (Institut de Génétique et de Biologie Moléculaire et Cellulaire)
"Cilia-driven Fluid Flow and Morphogenesis"
|
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Differentiation of Multiciliated and Secretory Cells |
| Discussion Leader: Michael McGuckin (University of Queensland) and Susan Dutcher (Washington University School of Medicine)
|
9:00 am - 9:20 am | Christopher Kintner (Salk Institute for Biological Studies)
"Control of Multiciliated Cells"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Thad Stappenbeck (Washington University School of Medicine)
"Autophagy and Mucus Cell Function"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Pascal Barbry (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire)
"Impact of micro RNAs on Vertebrate Multiciliogenesis in the Airway"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Jayaraj Rajagopal (Massachusetts General Hospital)
"Notch Signaling in Airway Mucus Metaplasia and Alveolar Development"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Brian Mitchell (Northwestern University)
"Deuterosome-mediated Centriole Biogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Lei Wang (Shanghai Institutes for Biological Sciences)
"MiR-34b Regulates Multiciliogenesis during Organ Formation in Zebrafish" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Cilia, Flow and Tissue Development |
| Discussion Leader: Iain Drummond (Massachusetts General Hospital) and Steven Brody (Washington University School of Medicine)
|
5:30 pm - 5:50 pm | Zhaoxia Sun (Yale University School of Medicine)
"Kidney Development"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Dominic Norris (MRC Harwell)
"Left-right Asymmetry"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Joseph Loturco (University of Connecticut)
"Dyslexia-related Gene Function and Ciliary Activity"
|
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Eamon Dubaissi (University of Manchester)
"The Development and Function of Secretory Cells in the Mucociliary Embryonic Frog Skin" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genomic, Proteomic and Glycomic Approaches to Cilopathies and Muco-ciliary Disease |
| Discussion Leader: Heymut Omran (Universitätsklinikum Münster) and Alessandra Livraghi-Butrico (University of North Carolina, Chapel Hill)
|
9:00 am - 9:20 am | Michael Knowles (University of North Carolina, Chapel Hill)
"Filling the Genomic Gap in MUC5AC: Characterization of Genetic Variation that Modifies Cystic Fibrosis Lung Disease Phenotypes" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Anne Dell (Imperial College London)
"Glycomics of Mucus"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Susan Dutcher (Washington University School of Medicine)
"Chlamydomonas Genomics/Proteomics to Understand Ciliogenesis"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Gunnar Hansson (University of Gothenberg)
"The Mucus Proteome"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hannah Mitchison (University College London)
"Genetics of Primary Ciliary Dyskinesia"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Amelia Shoemark (Royal Brompton Hospital)
"Bardet Biedl Syndrome Respiratory Cilia Structure and Function" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Cilia/Fluid Interactions |
| Discussion Leader: Lawrence Ostrowski (University of North Carolina, Chapel Hill) and Peter Satir (Albert Einstein College of Medicine)
|
5:30 pm - 5:50 pm | Richard Superfine (University of North Carolina, Chapel Hill)
"Mucociliary Interactions - Insights from a Vertical Clearance Model"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Martin Blum (University of Hohenheim)
"Flow at the Left-Right Organizer"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Raymond Goldstein (University of Cambridge)
"Ciliary Coordination and Metachronal Synchrony"
|
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Iain Drummond (Massachusetts General Hospital)
"Novel Factors Required for Ciliary Motility"
|
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Approaches to the Study of Cilia and Muco-ciliary Interactions |
| Discussion Leaders: Elizabeth Smith (Dartmouth College) and C. William Davis (University of North Carolina, Chapel Hill) |
9:00 am - 9:20 am | Shiaulou Yuan (Yale University School of Medicine)
"The Ciliary Axoneme is a Calcium Signaling Compartment Required for Determination of LR Asymmetry" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Maxence Nachury (Stanford University)
"Gating Ciliary Protein Entry"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Najl Valeyev (University of Exeter)
"Ciliary Systems Model for Ca2+, cAMP and Membrane Potential Regulation"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Camille Ehre (University of North Carolina, Chapel Hill)
"The Muc5ac Mucus Over-expression Model"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Claudius Werner (Universitätsklinikum Münster)
"Bridging Bench to Bedside in Primary Ciliary Dyskinesia"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Alessandra Livraghi-Butrico (University of North Carolina, Chapel Hill)
"Phenotypic Consequences of Muc5b Deletion in a Mouse Model of Defective Airway Mucus Clearance"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | From Protists to Mammals - Understanding Ciliary Function and Muco-ciliary Disease
|
| Discussion Leader: George Witman (University of Massachusetts Medical School) and Jeffrey Wine (Stanford University School of Medicine)
|
5:30 pm - 5:50 pm | Takashi Ishikawa (Paul Scherrer Institute)
"Three-dimensional Molecular Arrangement of Dynein, Tubulins and Regulatory Proteins in Flagella/Cilia" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Mustafa Khokka (Yale University School of Medicine)
"Xenopus for the study of Cilia"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Mark Hoegger (University of Iowa)
"Mucociliary Transport in Newborn Pigs" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Lawrence Ostrowski (University of North Carolina, Chapel Hill)
"Axonemal Dynein Function in Mice"
|
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |