Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Cilia,
Mucus and Mucociliary Diseases
Discussion Leaders: Martina Brueckner (Yale University, USA) and David Thornton (University of Manchester, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Burton Dickey (University of Texas MD Anderson Cancer Center, USA)
"Airway Mucus Production, Secretion, and Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Marcus Mall (Heidelberg University, Germany)
"Airway Mucus in the Pathogenesis and as a Therapeutic Target of Chronic Lung Diseases"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Daniela Nicastro (University of Texas Southwestern Medical Center, USA)
"Cryo-Electron Tomography Reveals How Cilia and Flagella Generate Motility"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Differentiation,
Assembly, and Regulation of Mucociliary Components
Discussion Leaders: Maimoona Zariwala (University of North Carolina at Chapel Hill, USA) and Gaia Pigino (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
9:00 am - 9:20 am
Monica Bettencourt-Dias (Calouste Gulbenkian Foundation, Instituto Gulbenkian de Ciencia, Portugal)
"Themes and Variations in Centrosome and Cilia Structure and Function in Development and Evolution"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephen King (University of Connecticut Health Center, USA)
"A Bioactive Peptide Amidating Enzyme Is Required for Ciliogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ivana Yang (University of Colorado Denver, USA)
"Contribution of Cilia to Mucociliary Defects in Pulmonary Fibrosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eric Haarmann (VU University Medical Center, The Netherlands)
"The X-Linked Inheritance in PCD: Discovery of a New Causative Gene"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Emily Hunter (Emory University, USA)
"Ida3 Is a Novel Inner Dynein Arm Assembly Factor that Is Transported by IFT in Growing Cilia"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Peter Jackson (Stanford University School of Medicine, USA)
"A New, Highly Conserved GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Martina Brueckner (Yale University, USA) and Cecilia Lo (University of Pittsburgh, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technical
Advancements to Study Mucociliary Biology
Discussion Leaders: Maureen Wirschell (University of Mississippi Medical Center, USA) and David Erle (University of California, San Francisco, USA)
7:30 pm - 7:50 pm
Susan Birket (University of Alabama at Birmingham, USA)
"New Insights Using Functional Anatomic Imaging to Interrogate the Airway Surface"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Katharina Ribbeck (Massachusetts Institute of Technology, USA)
"Probing Microbial Interactions with the Mucus Barrier"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brad Rosen (University of Iowa Carver College of Medicine, USA)
"Mucoinflammatory Bronchiectasis in Cystic Fibrosis Ferrets Does Not Require Infection"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Hill (University of North Carolina at Chapel Hill, USA)
"Matching Mucus to Cilia"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucociliary Dysfunction: Balancing Homeostasis and Pathophysiology
Session in memory of Mary Rose.
Discussion Leaders: Burton Dickey (University of Texas MD Anderson Cancer Center, USA) and Silvia Kreda (CF Center, University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 am
Steven Brody (Washington University in St. Louis, USA)
"Mechanisms
for Acquired and Genetic Motile Ciliopathies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Cecilia Lo (University of Pittsburgh, USA)
"Modeling the Complex Genetics of Ciliopathy in Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Johanna Raidt (Universitaetsklinikum Muenster, Germany)
"Mucociliary Function in the Fallopian Tube"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Bruce Stanton (Geisel School of Medicine, Dartmouth College, USA)
"P. aeruginosa Inhibits CFTR Cl Secretion by Human Airway Epithelial Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mahmoud Abou Alaiwa (University of Iowa, USA)
"Determinants of Mucociliary Transport in CF Airways"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Suzanne Cloonan (Weill Cornell Medicine, USA)
"Regulation of Cilia Function by Selective Autophagy in Lung Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Assembly and
Glycosylation
Discussion Leaders: Martin Blum (University of Hohenheim, Germany) and Gunnar C. Hansson (University of Gothenburg, Sweden)
7:30 pm - 7:50 pm
Thomas Gerken (Case Western Reserve University, USA)
"Making Sense of Mucin O-Glycosylation: It's a Lot More Complicated than We Thought"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Chris Kintner (Salk Institute for Biological Studies, USA)
"Transcriptional Regulation of Motile Ciliation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mary Porter (University of Minnesota, USA)
"Conserved Complexes Regulating Dynein Assembly and Ciliary Waveform"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Michael Tiemeyer (University of Georgia, USA)
"Functional Glycomics of Mucins"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucociliary Defense
and Immunity
Discussion Leaders: Ivana Yang (University of Colorado Denver, USA) and Alessandra Livraghi-Butrico (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 am
Bruce Bochner (Feinberg School of Medicine, Northwestern University, USA)
"Mucin Sialylation Regulates Eosinophilic Airways Inflammation via Siglec Engagment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sumaira Hasnain (University of Queensland, Australia)
"Understanding Cytokine Regulation of Cellular Stress in Infectious and Inflammatory Disease at Mucosal Surfaces"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rodney Newberry (Washington University School of Medicine in St. Louis, USA)
"New Roles for Goblet Cells in Immunity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Yogesh Saini (Louisiana State University, USA)
"Interactions Between Macrophages, Epithelial Cells, and Mucociliary Clearance Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
George Birchenough (University of Gothenburg, Sweden)
"Sentinel Goblet Cells: Goblet Cell-Mediated Mucosal Defense Beyond Mucus Layer Formation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Liping Zhang (National Institutes of Health, USA)
"Regulation of Mucin Biosynthesis and Secretion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cellular and
Developmental Aspects of Cilia and Mucus Biology
Discussion Leaders: Benedicte Durand (Claude Bernard University Lyon 1, France) and Michael McGuckin (Mater Research Institute - University of Queensland (MRI-UQ), Australia)
7:30 pm - 7:50 pm
Jeffrey Axelrod (Stanford University School of Medicine, USA)
"Uncoupling Centriole Replication from the Cell Cycle in Multiciliated Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Hiroshi Hamada (RIKEN Center for Developmental Biology, Japan)
"The Role of Immotile Cilia in Sensing the Fluid Flow for Left-Right Patterning"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Rui Song (University of California, Berkeley , USA)
"miR-34/449 in Multiciliated Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Pascal Barbry (Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, France)
"Regulation of Motile Ciliogenesis by microRNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Understanding of Muco- and Ciliopathies
Discussion Leaders: Mehmet Kesimer (University of North Carolina at Chapel Hill, USA) and Serge Amselem (INSERM, Pierre and Marie Curie University, UMRS 933, France)
9:00 am - 9:20 am
Brian Button (University of North Carolina at Chapel Hill, USA)
"Biophysical Properties of MUC5B and MUC5AC Mucus in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pleasantine Mill (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"A Multi-System Approach to Define Regulatory Networks Necessary for Ciliary Motility"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
David Schwartz (University of Colorado School of Medicine, USA)
"Idiopathic Pulmonary Fibrosis: A Genetic Disease that Involves Mucociliary Dysfunction of the Peripheral Airways"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Masahide Kikkawa (University of Tokyo, Japan)
"The Molecular Toolbox for Building Axonemal Microtubules"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Marie Legendre (INSERM, Pierre and Marie Curie University, UMRS 933, France)
"Genetic Heterogeneity in PCD: Efficiency and Limitations of NGS-Based Approaches"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Miriam Schmidts (Radboud University Nijmegen Medical Centre, The Netherlands)
"Large Scale Approaches to Understand Cilia and Ciliopathies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic
Targets and Strategies for Disorders of Mucus and Cilia
Discussion Leaders: Chris Evans (University of Colorado Denver, USA) and Brigitte Gomperts (UCLA Children's Discovery and Innovation Institute, USA)
7:30 pm - 7:50 pm
Richard Boucher (Marsico Lung Institute, University of North Carolina School of Medicine, USA)
"Therapeutic Strategies to Enhance Cilia, Mucus, and Mucociliary Functions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Amy Firth (University of Southern California, USA)
"iPS Cells for the Derivation of Motile Ciliated Cells and Applications for PCD and CF"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jung Soo Suk (Johns Hopkins University , USA)
"Mucus-Penetrating DNA Nanoparticles for Inhaled Gene Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kim Nielsen (Copenhagen University Hospital, Denmark)
"Randomized Trials in PCD - Start of a New Era"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure