Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Cilia, Mucus and Mucociliary Interactions
Discussion Leaders: Susan Dutcher (Washington University in St. Louis, USA) and Marcus Mall (Charité - Universtätsmedizin Berlin, Germany)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Martina Brueckner (Yale University, USA)
"Cilia in Congenital Heart Disease"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Gunnar Hansson (University of Gothenburg, Sweden)
"Mucins: The Chief Components of Airway Mucus"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Steven Rowe (University of Alabama at Birmingham, USA)
"Mucociliary Interactions: Integrated Functions of Mucus and Cilia in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics and Genomics of Cilia and Mucus Biology
Discussion Leaders: Marie Legendre (NSERM U933, Sorbonne Université / Assistance Publique-Hôpitaux de Paris (AP-HP), France) and Colin Bingle (University of Sheffield, United Kingdom)
9:00 am - 9:20 am
Laure-Emmanuelle Zaragosi (Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, France)
"Single Cell Sequencing to Investigate Multiciliogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
David Schwartz (University of Colorado School of Medicine, USA)
"Pulmonary Fibrosis and MUC5B: Novel Insights into an Incurable Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maimoona Zariwala (University of North Carolina at Chapel Hill, USA)
"Insights into the Genetics of PCD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Erle (University of California, San Francisco, USA)
"Airway Epithelial Reprogramming in Asthma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jamie Everman (National Jewish Health, USA)
"Airway Epithelial Intelectin-1 Secretion Affects IL-13-Induced Mucus-Driven Airway Dysfunction and Expression of the Gene Is Regulated by an eQTL that Is Associated with Development of Asthma and IBD"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Renat Shaykhiev (Weill Cornell Medicine, Cornell University, USA)
"Transcriptomics of Airway Basal Cell Fate and Chronic Airway Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Pleasantine Mill (MRC Human Genetics Unit, University of Edinburgh, United Kingdom), Susan Dutcher (Washington University in St. Louis, USA) and Katharina Ribbeck (Massachusetts Institute of Technology, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Developmental and Gene Regulatory Determinants of Mucociliary Function
Discussion Leaders: John Dickinson (University of Nebraska, USA) and Pleasantine Mill (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
6:00 pm - 6:20 pm
Daniel Lafkas (Genentech Inc., USA)
"Notch Signaling in Mucociliary Fate Determination"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Gang Chen (University of North Carolina at Chapel Hill, USA)
"The Regulation of MUC5B Expression by ER Stress Transcription Factor XBP1S"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Achim Gossler (Hannover Medical School, Germany)
"Genetic Regulation of Motile Cilia Functions"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Samir Kelada (University of North Carolina at Chapel Hill, USA)
"Bpifb1 Regulation of Muc5b"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Assembly and Structure: Translating Messages to Build Mucins and Cilia
Discussion Leaders: Eszter Vladar (University of Colorado School of Medicine, USA) and Eamon Dubaissi (University of Manchester, United Kingdom)
9:00 am - 9:20 am
Alice Meunier (INSERM DRPA06, France)
"From 2 to 100: How Multiciliated Cells Amplify Centrioles"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Carla Maria Ribeiro (Marsico Lung Institute / Cystic Fibrosis Center, University of North Carolina at Chapel Hill, USA)
"Inositol Requiring Enzyme 1β: A Key Regulator of Airway Mucin Production"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kristen Verhey (University of Michigan Medical School, USA)
"How Microtubules and Motors Interact for Cilia Functions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Tal Ilani (Weizmann Institute of Science, Israel)
"Regulation of Protein Assembly and Function by Disulfide Catalysts"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Caroline Ridley (University of Manchester, United Kingdom)
"The C-Terminal Dimerisation Domain of Mucin MUC5B: Structure, Stability and Interactions"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Peter Walentek (University Medical Center Freiburg, Germany)
"Molecular Mechanisms Regulating Mucociliary Morphogenesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Trafficking and Transport of Mucociliary Components
Discussion Leaders: Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR, Singapore) and David Thornton (University of Manchester, United Kingdom)
6:00 pm - 6:20 pm
Gaia Pigino (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Studies of Cilia and Intraflagellar Transport by 3D CryoEM"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Ana Maria Jaramillo (University of Texas MD Anderson Cancer Center, USA)
"Mucin Exocytic Mechanisms"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Gerard Dougherty (Universitätsklinikum Münster, Germany)
"Regulation of Multiciliated Cell Dyneins"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Alessandra Livraghi-Butrico (University of North Carolina at Chapel Hill, USA)
"In Vivo Effects of Mucin Assembly on Mucociliary Functions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Biology of Cilia, Flow and Mucin Components
Discussion Leaders: Burton Dickey (University of Texas MD Anderson Cancer Center, USA) and Julien Vermot (Institute of Genetics and Molecular and Cellular Biology, France)
9:00 am - 9:20 am
Chanjae Lee (University of Texas at Austin, USA)
"A Liquid-Like Organelle for Axonemal Dynein Assembly in Ciliated Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Emily Hunter (Emory University, USA)
"New Insights into IFT Regulated Transport of Axonemal Dyneins and Cilia Length"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Mehmet Kesimer (University of North Carolina at Chapel Hill, USA)
"Biochemical Changes in MUC5AC and MUC5B in Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Eszter Vladar (University of Colorado School of Medicine, USA)
"Noncanonical Wnt Signaling in Airway Epithelial Planar Polarization and Differentiation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Yohannes Tesfaigzi (Lovelace Respiratory Research Institute, USA)
"Bcl-2 Modifying Factor (Bmf) Reduces Goblet Cell Metaplasia by Enhancing Mucin Degradation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Kaitlin Ching (Stanford University, USA)
"Controlling Centriole and Cilium Number in Olfactory Sensory Neurons"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Regina Faubel (University of Pittsburgh, USA)
"Cilia-Based Flow Network in the Brain Ventricles"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Determinants of the Cilia-Fluid Interface and Extracellular Spaces
Discussion Leaders: Jean-Luc Desseyn (INSERM, France) and Katharina Ribbeck (Massachusetts Institute of Technology, USA)
6:00 pm - 6:20 pm
Laura Campbell (University of Manchester, United Kingdom)
"Innate Lymphoid Cell Anti-Helminth Defense via Mucins in Gut and Lungs"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Stephen King (University of Connecticut Health Center, USA)
"Cilia Act as a Regulated Secretory Pathway for the Peptide Amidating Enzyme and Its Bioactive Products"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Jose Ordovas-Montanes (Ragon Institute of MGH, MIT and Harvard / Broad Institute of MIT and Harvard, USA)
"Single-Cell Genomics of Mucosal Barrier Tissues"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Nathalie Jurisch-Yaksi (Kavli Institute for Systems Neuroscience, NTNU, Norway)
"Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Gregg Duncan (University of Maryland, USA)
"Mucus Biophysics: Determinants of Gel Size and Mobility"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Model Systems for Integration of Cilia and Mucus to Host Functions
Discussion Leaders: Richard Boucher (The Marsico Lung Institute/UNC Cystic Fibrosis Center, University of North Carolina at Chapel Hill, USA) and Zhaoxia Sun (Yale University School of Medicine, USA)
9:00 am - 9:20 am
Annie Viallat (CNRS / Aix Marseille Université, France)
"Spatiotemporal Organization of Cilia Drives Mucus Mixing in Airway Epithelia"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brigitte Gomperts (University of California, Los Angeles, USA)
"3D Bioengineering of Lung"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jeremy Reiter (University of California, San Francisco, USA)
"Global Techniques for Novel Mechanisms of Ciliary Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Max Seibold (National Jewish Health, USA)
"Network Analysis of Goblet Cell Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Patricia Yeyati (MRC Human Genetics Unit, United Kingdom)
"Novel Cilia Biosensor Tracking Single Cell Cycle Kinetics and Ciliary Cycle"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
George Solomon (University of Alabama at Birmingham, USA)
"Translational Imaging Studies of Mucociliary Function and Dysfunction"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Implications of Mucociliary Biology to Health and Disease
Discussion Leader: Susan Birket (University of Alabama at Birmingham, USA)
6:00 pm - 6:20 pm
Heymut Omran (University Hospital Muenster, Germany)
"RNA Replacement Therapy Approaches for Motile Cilia Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Corrine Kliment (University of Pittsburgh School of Medicine, USA)
"Mitochondrial Adenine Nucleotide Translocase Influences Ciliary Function and Airway Homeostasis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Eleanor Dunican (School of Medicine and Medical Science, University College Dublin, Ireland)
"Mucus Obstruction in Asthma"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Thomas Ferkol (Washington University in St. Louis, USA)
"Clearing Lungs with ENaC Inhibition in Primary Ciliary Dyskinesia Trial"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Camille Ehre (University of North Carolina at Chapel Hill, USA)
"Development and Deployment of Efficacious Mucolytic Therapies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure