Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Prospects and Themes in Mucociliary Biology
Discussion Leaders: Matthias Salathe (University of Kansas Medical Center, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Susan Dutcher (Washington University in St. Louis, United States)
"Cilia: The Assembly and Function of Cilia"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Christopher Evans (University of Colorado School of Medicine, United States)
"Molecular and Functional Requirements for Airway Mucus"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Steven Brody (Washington University School of Medicine, United States)
"Mucociliary Interactions: Integrated Functions of Mucus and Cilia"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic and Molecular Understanding of Mucociliary Disorders
Discussion Leaders: Hannah Mitchison (University College London, United Kingdom) and Max Seibold (National Jewish Health, United States)
9:00 am - 9:20 am
Kenichi Okuda (University of North Carolina at Chapel Hill, United States)
"Pathways Maintaining Mucus Homeostasis in the Human Distal Airway"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Peter Jackson (Stanford University School of Medicine, United States)
"SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Kristina Johansson (University of Gothenburg, Sweden)
"Regulation of Airway Mucus by miRNAs"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Ya'el Courtney (Harvard University, United States)
"A Choroid Plexus Apocrine Secretion Mechanism Modulates Cerebrospinal Fluid Contents and Instructs Cortical Development"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Karina Violou (University Hospital Münster, Germany)
"Ciliogenesis of Multiple Motile Cilia in Health and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
John Fahy (University of California, San Francisco, United States)
"Radiographic and Pathologic Features of Airway Mucus Plugs in Asthma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Amelia Shoemark (University of Dundee Ninewells Hospital, United Kingdom)
"Primary and Secondary Ciliary Dysfunction in the Pathophysiology of Bronchiectasis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Alessandra Livraghi-Butrico (University of North Carolina at Chapel Hill, United States) and Girish Mali (University of Bristol, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology
Discussion Leaders: Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR, Singapore) and Jean-Luc Desseyn (Univ. Lille/Inserm/CHU Lille, France)
6:00 pm - 6:20 pm
Sophie Darch (University of South Florida, United States)
"Mucin Interactions with Bacterial Aggregates in the CF Lung"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Virginie Hamel (University of Geneva, Switzerland)
"Expansion Microscopy for Structural Cell Biology: From Molecular Architecture to Retinopathies"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Silvia Kreda (CF Center, University of North Carolina at Chapel Hill, United States)
"Regulation of Mucin Exocytosis and Mucus Production in the Lung"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Wallace Marshall (University of California, San Francisco, United States)
"Flagellar Length Control in Chlamydomonas"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mucin and Cilia Biophysics
Discussion Leaders: David Hill (University of North Carolina at Chapel Hill, United States) and Julien Vermot (Imperial College London, United Kingdom)
9:00 am - 9:20 am
Zeynep Ökten (Technical University of Munich, Germany)
"Biophysics of IFT Molecular Motors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elisabeth Nystrom (University of Kiel/ University of Gothenburg, Sweden)
"CLCA1 Dependent Mucus Proteolysis in Health and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Francesco Boselli (Cambridge University, United Kingdom)
"Fluid Mechanics of Mosaic Ciliated Tissues"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Gerald Fuller (Stanford University, United States)
"In Vitro Measurement of the Viscoelasticity of Mucus Layers above Living Bronchial Epithelial Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kirsty Wan (University of Exeter, United Kingdom)
"Coordinating Ciliary Arrays: From Synchrony to Metachrony"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Rubinstein (Duke University, United States)
"Unexpected Rheological Properties of Mucus"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Raju Bej (Freie Universität Berlin, Germany, Germany)
"Mucus-Inspired Synthetic Hydrogels"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structure and Function
Discussion Leaders: Girish Mali (University of Bristol, United Kingdom) and Colin Bingle (University of Sheffield, United Kingdom)
6:00 pm - 6:20 pm
Alan Brown (Harvard Medical School, United States)
"Structural Insights into the Axoneme of Human Respiratory Cilia"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Deborah Fass (Weizmann Institute of Science, Israel)
"Structural Basis of Mucin Multimerization"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Mary Porter (University of Minnesota, United States)
"Mbo Mutations Reveal New Details of Doublet Microtubule Asymmetry and A Complex That Stabilizes Assembly of Inner Arm Dynein B"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Jamie Everman (National Jewish Health, United States)
"Spatial Transcriptomic and Proteomic Analysis of the Human Airway Epithelium Reveals Molecular Heterogeneity of Mucus Secretory Cells"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Katerina Toropova (Birkbeck, University of London, United Kingdom)
"IFT-A Structure Reveals Carriages for Membrane Protein Transport into Cilia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling and Host Defense
Discussion Leaders: Anna Ermund (University of Gothenburg, Sweden) and Dominic Norris (MRC Harwell Institute, United Kingdom)
9:00 am - 9:20 am
Julia Duerr (Charité - Universitätsmedizin Berlin, Germany)
"Pathogenesis of Pulmonary Fibrosis in the Nedd4-2 KO Mouse"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hiroshi Hamada (RIKEN Center for Biosystems Dynamics Research, Japan)
"Mechanosensing of Fluid Flow by Immotile Cilia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jessica Kramer (University of Utah, United States)
"Mucins Inhibit Coronavirus Infection in a Glycan-Dependent Manner"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Yohannes Tesfaigzi (BRIGHAM AND WOMEN'S HOSPITAL, United States)
"Effects of Wood Smoke Constituents on Mucin Gene Expression in Susceptible Individuals Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Ryszard Grygorczyk (University of Montreal, Canada)
"Mucin Granule Intraluminal Viscosity Reveals an Inherent Mucus Defect in Cystic Fibrosis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Shiaulou Yuan (Massachusetts General Hospital and Harvard Medical School, United States)
"Illuminating the Role of Intra-Ciliary Calcium Signaling in Cardiac Left-Right Asymmetry"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Carlos Milla (Stanford University, United States)
"Filamentous Bacteriophages Produced by Pseudomonas Entangle Cilia and Impair Mucociliary Clearance"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Regulation and Function
Discussion Leaders: Nathalie Jurisch-Yaksi (Norwegian University of Science and Technology, Norway) and Eszter Vladar (University of Colorado School of Medicine, United States)
6:00 pm - 6:20 pm
David Parsons (University of Adelaide / Women's and Children's Hospital, Australia)
"Spinners, Movers and Shakers: Novel Airway Surface Behaviours of Externally-Controlled Magnetic Particles in vivo ."
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Gaspar Jekely (University of Heidelberg, Germany)
"A Ciliary Photoreceptor-Cell Circuit Mediates Pressure Response in Marine Zooplankton"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Leah Reznikov (University of Florida, United States)
"Club Cell CREB Regulates the Goblet Cell Transcriptional Network and Pro-Mucin Effects of IL-1B in Male Murine Airways"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Dagmar Wachten (Institute of Innate Immunity, University of Bonn, Germany)
"Shedding Light on Primary Cilia Signaling and Function"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
John Dickinson (University of Nebraska, United States)
"Autophagy of Mucin Granules Contributes to the Resolution of Airway Mucous Cell Metaplasia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Disease Modeling
Discussion Leaders: Nam Soo Joo (Stanford University, United States) and Brian Mitchell (Northwestern University, United States)
9:00 am - 9:20 am
Mustafa Khokha (Yale University, United States)
"Basal Body Number Scales with Cell Size Via Mechanical Stretch Sensing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Engelhardt (University of Iowa, United States)
"Functions of the Pulmonary Ionocyte in the Proximal Ferret Airways"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Helen Willsey (UCSF, United States)
"Pleiotropy of Autism-Associated Chromatin Regulators"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Brendan Dolan (University of Gothenburg, Sweden)
"Expanding Secretion, a Distinctive Mode of Goblet Cell Secretion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rebecca Burdine (Princeton University, United States)
"Cilia and Symmetry in Developmental Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Susan Birket (University of Alabama at Birmingham, United States)
"Progressive Development of Abnormal Mucus Sets the Stage for Chronic P. aeruginosa Infection in Cystic Fibrosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jovana Deretic (Koç University, College of Sciences, Turkey)
"Retinopathy-Linked Protein CCDC66 is a Multifaceted Regulator of Diverse Microtubule Arrays Important for Motile Cilia Formation and Function"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Technologies to Study Cilia, Mucus and Mucociliary Interactions
Discussion Leaders: Alessandra Livraghi-Butrico (University of North Carolina at Chapel Hill, United States) and Benedicte Durand (University Claude Bernard Lyon-1, France)
6:00 pm - 6:20 pm
Raman Das (University of Manchester, United Kingdom)
"Modulation of the Cell Signaling Response by Primary Cilium Remodeling During Vertebrate CNS Development"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
David Stoltz (University of Iowa, United States)
"Mucus, Disease, and Defective Mucociliary Transport"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Camille Boutin (IBDM CNRS UMR 7288, France)
"Structural and Molecular Characterization of Vertebrates Deuterosomes"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Emma Hilton (University of Manchester, United Kingdom)
"The Xenopus Tropicalis Tadpole: A Simple, Live Animal Model of Mucociliary Clearance"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Jeremy Reiter (University of California, San Francisco, United States)
"How The Airway Makes Multiciliated Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure