Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Biochemistry and Biophysics of Mucus
Discussion Leader: Ana Maria Jaramillo (University of Colorado School of Medicine, United States)
3:15 pm - 3:55 pm
Katharina Ribbeck (Massachusetts Institute of Technology, United States)
"Partners in Slime – How Mucus Keeps You Healthy"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Genetic and Molecular Mechanisms Driving Mucociliary Function
Discussion Leader: Fraser McPhie (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
5:30 pm - 5:40 pm
Antonio Cerullo (City University of New York - Advanced Science Research Center, United States)
"Comparative Mucomic Analysis of Functionally Distinct Secretions from Cornu aspersum , Cassiopeia xamachana , and Hoplobatrachus rugulosus "
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Magdalena Brislinger-Engelhardt (University Freiburg Medical Center, Freiburg, Germany, Germany)
"Temporal Integration of Notch Signaling in Mucociliary Pattern Formation"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Chloe Wu (Massachusetts Institute of Technology, United States)
"Mucin Glycans Drive Oral Microbial Community Composition and Function"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Erik Quiroz (University of Iowa, United States)
"RBL2 Represses Multicilin Transcriptional Activity to Inhibit Multiciliogenesis"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Ya'el Courtney (Harvard University, United States)
"A Choroid Plexus Apocrine Secretion Mechanism Modulates Cerebrospinal Fluid Contents and Instructs Cortical Development"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Ana Maria Jaramillo (University of Colorado School of Medicine, United States)
"Mechanisms of Cysteine-Mediated Polymerization and Secretion of Muc5ac and Muc5b"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Anandi Rajan (University of Gothenburg, Sweden)
"Brachyspira Virulence Factors Involved in Infection of Colonic Epithelial Cells"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Visualization of Cilia and Mucus Dynamics
Discussion Leader: Antonio Cerullo (City University of New York - Advanced Science Research Center, United States)
9:00 am - 9:10 am
Ruth Maria Urbantat (Charité - Universitätsmedizin Berlin, Germany)
"Establishing the Conditionally Reprogrammed Cell Technology for Precision Medicine in Primary Ciliary Dyskinesia"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Aditi Kuppe (Charité – Universitätsmedizin Berlin, Germany)
"Novel Polymeric Reducing Agents as Mucus Modulators in Human Cystic Fibrosis Mucus"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Fraser McPhie (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"Mutations in the Tubulin Isotype TUBB4B Result in a Dominant-Negative Ciliopathy"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Kaitlyn Rouillard (UNC Chapel Hill, United States)
"Combination Treatment to Improve Mucociliary Transport of Pseudomonas aeruginosa Biofilms"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jane Y. Y. Chui (University of Cambridge, United Kingdom)
"Synchronization of Flagella in Cellular Carpets Derived From Volvox Carteri"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Francesco Boselli (Cambridge University, United Kingdom)
"Fluid Mechanics of Mosaic Ciliated Tissues"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Corbin Black (McGill University, Canada)
"Native Doublet Microtubules from Tetrahymena Thermophila Reveal the Importance of Outer Junction Proteins"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Panel: Research, Funding, & Opportunities in Science
Discussion Leader: Brian Button (University of North Carolina at Chapel Hill, United States)
1:30 pm - 2:30 pm
Panel Discussion
- Research, Funding, & Opportunities in Science
Katharina Ribbeck (Massachusetts Institute of Technology, United States)
Jeremy Reiter (University of California, San Francisco, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
