7:30 pm Opening Remarks - Gerard Karsenty

7:40 pm Collagen and other extracellular matrix proteins and regulation during development

[Discussion leader: Kathryn Cheah (University of Hong Kong)]

7:45 Benoit de Crombrugghe (M.D. Anderson Cancer Center), "Sox 9 is essential for chondrocyte differentiation"

7:50 Sherrill Adams (University of Pennsylvania), "The chick type III collagen gene is transcribed from two cell type-specific promoters"

8:05 Reinhard Faessler (Lund University), "Function of perlecan during mouse development"

8:35 Yoshi Yamada (NIH) "Cartilage proteoglycan aggregates are essential for skeletal development"

8:50 Thiennu Vu (University of California) "Gelatinase B, extracellular matrix degradation, and angiogenesis at the skeletal growth plate"

9:15 General discussion

9:30 Opening reception

7:30 am Breakfast

9:00 am Cell-matrix interaction

[Discussion leader: Caroline Damsky (University of California San Francisco)]

9:15 Elaine Raines (University of Washington), "Dynamic regulation of smooth muscle cell responsiveness to growth factors by specific collagen-matrix receptor interactions"

10:10 Barry Sudbeck (University of California-San Francisco), "Collagen gel contraction: roles for Focal Adhesion Kinase and Jun Kinase"

10:25 Coffee Break (Group photo at this time)

10:45 Leslie Parise (University of North Carolina) "Integrins, signaling and migration"

11:25 Rebecca L. Rich (Texas A&M University), "Collagen binding by the human alpha- I integrin. I domain and the S. aureus Can MSCRAMM"

11:40 General discussion

12:30 pm Lunch

6:00 pm Dinner

7:30 pm Genetic studies of the function of the collagen and extracellular matrix proteins

[Discussion leader: Jouni Uitto (Jefferson Medical College)]

7:35 Irma Thesleff (University of Helsinki), "Molecular mechanisms of tissue interactions in tooth development"

8:10 Daniel Greenspan (University of Wisconsin), "Novel developmental proteases and their role in embryonic development"

8:25 Leena Ala-Kokko (University of Oulu), "Collagen IX mutations cause intervertebral disc disease and mild cartilage disease"

9:00 Malin Sund (University of Oulu), "Embryonic lethality in mice expressing mutated type XIII collagen"

9:15 Break

9:35 Leena Bruckner-Tuderman (University of Munster), "Molecular pathology of collagen types VII and XVII in epidermolysis bullosa"

10:05 Jouni Uitto - comment "Type VII collagen null mice as models for dystrophic epidermolysis bullosa"

10:15 Jamie Fitzgerald (University of Melbourne), "Proteosomal degradation of assembly-impaired mutant type I collagen proa 1 (1) chains"

10:25 General discussion

7:30 am Breakfast

9:00 am Genetic studies of the function of the collagen and extracellular matrix proteins

[Discussion leader: Peter Byers (University of Washington)]

9:10 Kazuhiro Nagata (Tokyo Institute of Technology), "Transcriptional regulation of hsp47, a collagen-specific molecular chaperone that is essential for mouse development"

9:45 Neil Bulleid (University of Manchester), "Procollagen folding, assembly and secretion"

10:20 John Bateman (University of Melbourne), "Proteasomal degradation of assembly- impaired mutant type I collagen procc 1 (1) chains"

10:30 Coffee Break

10:50 Shireen Lamande (University of Melbourne), "Type VI collagen mutations in Bethlern myopathy"

11:00 Matt Warman (Case Western Reserve University), "Secreted growth factors in human skeletal dysplasias"

11:40 Francesco Ramirez (Mt. Sinai Medical Center)

11:55 General discussion

12:30 pm Lunch

6:00 pm Dinner

7:30 pm Molecular assembly of collagens

[Discussion leader: Karl Kadler (University of Manchester)]

7:40 Albert Luini (Consorzio Mario Negri Sud), "Mechanisms of procollagen secretion"

8:15 Darwin Prockop (MCP Halmemann), "A single binding site in the alpha 1 (1) chain directs self-assembly of type I collagen into fibrils"

8:50 John Trotter (University of New Mexico), "Collagen fibril formation in invertebrates"

9:05 Break

9:25 Shukti Chakrovarti (Case Western Reserve University), "Lumican in collagen fibril assembly and connective tissue fimctions: lessons from knock-out mice"

10:00 Ake Oldberg (University of Lund), "Role of fibromodulin in the assembly of collagen. matrices"

10:35 Paul Bishop (University of Manchester), "Opticin: a novel collagen fibril-associated glycoprotein. in vitreous"

10:50 Florence Ruggiero (CNRS), "Structure-fimction relationships of collagen V molecules"

11:05 General discussion

7:30 am Breakfast

9:00 am Signal transduction in extra-cellular matrix

[Discussion leader: Martin Humphries (University of Manchester)

9:10 Humphrey Gardner (The Scripps Research Institute), "Roles of the collagen binding integrins in downstream signaling and regulation of collagen turnover"

10:00 Nick Brown (Cambridge University), "Dissection of integrin signaling in Drosophila"

10:50 Coffee Break

11:10 Wolfgang Vogel (Georg-Speyer-Haus), "collagen induced signaling by discoidin domain receptors"

12:00 General discussion

12:30 pm Lunch

6:00 pm Dinner

7:30 pm Regulation of expression of collagen and other extracellular matrix genes

[Francesco Ramirez (Mt Sinai Medical School of Medicine)]

7:40 Tomoatsu Kimura (Toyarna Medical & Pahrmaceutical University), "In vivo gene transfer and cartilage-specific expression"

8:10 Richard Mayne (University of Alabama at Birmingham)

8:25 Giorgio M. Bressan (University of Padova), "Regulation of transcription of the Co/6al gene: analysis of core promoter, proximal activating sequences and one tissue-specific enhancer region"

8:55 Break

9:15 George D. Yancopoulos (Regeneron Pharmaceuticals, Inc.), "The DDRs: Novel collagen receptors similar to growth factor-like receptor tyrosine kinases"

10:00 General discussion

7:30 am Breakfast

9:00 am Other extracellular matrix proteins

[Paul Bornstein (University of Washington)]

9:05 Helen Sage (The Hope Heart Institute), "SPARC, collagen, and TGF- : a trio for regulation of cell-cycle and cell-matrix interactions"

9:50 Krisztina Rosenberg (Lund University), "COMP shows high affinity Zn-dependent interaction with triple helical collagen"

10:05 Coffee Break

10:25 Cecilia Giachelli (University of Washington), "Osteopontin inhibition of ectopic calcification: evidence for matrix-and cell-dependent mechanisms"

11:10 Marlene Rabinovitch (The Hospital for Sick Children), "Tenascin-C: a matter of life but not quite death"

11:50 Jiann-Jiu Wu (University of Washington), "Identification of matrilin-3 in fetal cartilage"

12:00 General discussion

12:30 pm Lunch

6:00 pm Banquet

7:30 pm Keynote speaker
Doug Melton (Harvard University)