| Sunday, July 29 |
| Session 1. | CELL-MATRIX INTERACTIONS AND SIGNAL TRANSDUCTION IN THE EXTRACELLULAR MATRIX (ECM) |
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| Discussion Leader: Taina Pihlajaniemi, University of Oulu, Finland |
| 7:30 pm | OPENING REMARKS, Kari Kivirikko and Peter Byers |
| 7:45 pm | Shoukat Dedhar, University of British Columbia, Canada
Integrin linked kinase (ILK) |
| 8:20 pm | Mary M. Zutter, Washington University School of Medicine, St. Louis
alpha 2 beta 1 integrin-dependent regulation of cell phenotype: From man to mouse |
| 8:55 pm | Jyrki Heino, University of Jyvaskyla, Finland
Integrins and selective recognition of distinct collagen types |
| 9:10 pm | Wolfgang F. Vogel, Institute for Biomedical Research, Frankfurt, Germany
Employing microarrays to identify downstream targets of DDRs, tyrosine kinase receptors activated by collagen |
| 9:25 pm | General discussion |
| 9:30 pm | RECEPTION CONTINUED |
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| 7:30 am | BREAKFAST |
| Session 2. | STRUCTURE AND MOLECULAR ASSEMBLY OF COLLAGENS |
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| Discussion Leader: Barbara Brodsky, UMDNJ-Robert Wood Johnson Medical School, Piscataway |
| 9:00 am | Conference Information |
| 9:10 am | Barbara Brodsky: Introduction |
| 9:20 am | Anton Persikov, UMDNJ-Robert Wood Johnson Medical School, Piscataway
Basic principles of triple helix conformation and stability |
| 9:50 am | Luigi Vitagliano, University of Naples, Italy
The effect of hydroxyproline in triple helix stability and association |
| 10:05 am | GROUP PHOTO AND COFFEE BREAK |
| 10:40 am | Ronald Raines, University of Wisconsin, Madison
Stereoelectronic basis for collagen stability |
| 10:55 am | Sergei Leikin, National Institute of Health
Triple helix unfolding and refolding in collagen structure, interactions and diseases
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| 11:15 am | Neil Bulleid, University of Manchester, U.K.
Maturation of procollagen in the endoplasmic reticulum |
| 11:45 am | Billy Hudson, University of Kansas Medical Center, Kansas, KS
Organization and mechanism of chain-specific assembly of type IV collagen networks |
| 12:00 am | General discussion |
| 12:30 | LUNCH |
| 5:00 pm | POSTER SESSION 1
Organized by Peter Byers |
| 6:00 pm | DINNER |
| Session 3: | DOMAINS OF COLLAGENS AND OTHER ECM PROTEINS AND THEIR FUNCTIONS |
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| Discussion Leader: Juergen Engel, University of Basel, Switzerland |
| 7:30 pm | Juergen Engel, Introduction |
| 7:35 pm | Robert Liddington, The Burnham Institute, La Jolla
Matrix-integrin interactions in three dimensions |
| 8:10 pm | Johannes Eble, University of Muenster, Germany
Rhodocetin, a novel RGD-independent disintegrin, acts as competitive inhibitor of collagen binding to a2b1 integrin |
| 8:45 pm | Munirathinam Sundaramoorthy, University of Kansas Medical Center, Kansas, KS
Molecular interactions governing the chain-specific assembly of type IV collagen networks |
| 9:00 pm | Calvin Kuo, Stanford University, Stanford, CA
Motogenic and morphogenic properties of collagen XVIII endostatin domain |
| 9:20 pm | General Discussion |
| 9:30 pm | POSTER SESSION 1 CONTINUED |
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| 7:30 am | BREAKFAST |
| Session 4. | PROCESSING AND DEGRADATION OF COLLAGENS AND ENZYMES INVOLVED |
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| Discussion Leader: Darwin J. Prockop, Tulane University, New Orleans |
| 9:00 am | Darwin J. Prockop: Introduction |
| 9:10 am | Johanna Myllyharju, University of Oulu, Finland
Prolyl 4-hydroxylases, the key enzymes of collagen synthesis |
| 9:50 am | Sergei Boudko, University of Basel, Switzerland
Stabilization and nucleation of the collagen triple helix by a C-terminal oligomerization domain |
| 10:05 am | COFFEE BREAK |
| 10:25 am | Daniel Greenspan, University of Wisconsin, Madison
Recent insights into BMP-1 related proteins |
| 11:05 am | Matthew P. Leighton, University of Manchester, UK
Studies on the prodomain cleavage of BMP-1 |
| 11:20 am | David Hulmes, Université Claude Bernard Lyon 1, France
Structure of procollagen C-propeptide trimer and its interaction with
procollagen C-proteinase enhancer |
| 11:35 am | Henning Birkedal-Hansen, National Institutes of
Health, Bethesda, MD
Mechanism of degradation of fibrillar collagens: Fourty years after tadpole collagenase
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| 12:15 am | General discussion
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| 12:30 | LUNCH |
| 6:00 pm | DINNER |
| Session 5: | COLLAGENS AND OTHER ECM PROTEINS IN DEVELOPMENT |
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| Discussion Leader: Bjorn R. Olsen, Harvard Medical School, Boston |
| 7:30 pm | Bjorn R. Olsen: Introduction |
| 7:40 pm | Norbert Perrimon, Harvard Medical School, Boston
The role of cell-matrix interactions and integrins during retraction of the germ band in Drosophila embryos |
| 8:15 pm | Maria Rita Passos-Bueno, University of Sao Paulo, Brazil
Mutations in collagen XVIII in patients with Knobloch syndrome |
| 8:50 pm | Shannon Fisher, Johns Hopkins University School of Medicine, Baltimore
Genetic analysis of collagen synthesis and processing in zebrafish skeletogenesis |
| 9:05 pm | Linda Sandell, Washington University School of Medicine, St. Louis
Type IIA procollagen N propeptide functions as an antagonist of bone
morphogenic proteins |
| 9:20 pm | General discussion
|
|
| 7:30 am | BREAKFAST |
| |
| Session 6. | MOUSE MODELS OF THE FUNCTIONS OF COLLAGENS AND OTHER ECM PROTEINS |
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| Discussion Leader: Gerard Karsenty, Baylor College of Medicine, Houston |
| 9:00 am | Gerard Karsenty: Introduction |
| 9:10 am | Lauri Eklund, University of Oulu, Finland
Consequences of the lack of type XV and XVIII collagens |
| 9:45 am | Joan Marini, National Institutes of Health, Bethesda
The brittle mouse model for non-lethal osteogenesis imperfecta has decreased bone density, bone formation rate and femur strength |
| 10:00 am | COFFEE BREAK |
| 10:20 am | Francesco Ramirez, Mt Sinai School of Medicine, New York
Type XIX collagen regulates gastrointestinal function |
| 10:55 am | Bjorn Olsen, Harvard Medical School, Boston
Vascular endothelial growth factor and skeletal development |
| 11:30 am | Raija Soininen, University of Oulu, Finland
Homozygous inactivation of the lysyl oxidase (LOX) gene in mouse leads to a severe cardiovascular dysfunction and perinathal death |
| 11:45 am | James Bristow, University of California San Francisco, San Francisco
Tenascin-X regulates collagen fibril deposition in humans and mice |
| 12:00 am | General discussion |
| 12:30 | LUNCH |
| 5:00 pm | POSTER SESSION 2
Organized by Peter Byers |
| 6:00 pm | DINNER |
| Session 7. | NEW COLLAGENS AND OTHER ECM PROTEINS |
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| Discussion Leader: Robert E. Burgeson, Harvard Medical School, Boston |
| 7:30 pm | Robert E. Burgeson: Introduction |
| 7:35 pm | Marion Gordon, UMDNJ-Robert Wood Johnson Medical School, Piscataway
Collagens and the twenty first century |
| 8:10 pm | Manuel Koch, Harvard Medical School, Boston
Collagens XXII and XXIV: novel components of tissue junctions |
| 8:45 pm | Leena Bruckner-Tuderman, University of Muenster, Germany
Collagen XXII in the hair follicle |
| 9:00 pm | Volkhard Lindner, Maine Medical Center, Scarborough
Remodulin, a novel gene modulating collagen matrix |
| 9:15 pm | General discussion |
| 9:30 pm | POSTER SESSION 2 CONTINUED |
|
| 7:30 am | BREAKFAST |
| Session 8. | MOLECULAR PATHOLOGY OF COLLAGENS |
|
| Discussion Leader: Leena Bruckner-Tuderman, University of Muenster, Germany |
| 9:00 am | Leena Bruckner-Tuderman: Introduction |
| 9:10 am. | Johanna Pispa, University of Helsinki, Finland
Tumor necrosis factor signalling and ectodermal dysplasia |
| 9:50 am | James Page, University of Washington, Seattle
Defects in the C-propeptide of the proalpha chains of type I procollagen hinder molecular assembly and result in both classical and non-classical variants of osteogenesis imperfecta |
| 10:05 am | COFFEE BREAK |
| 10:30 am | Mon-Li Chu, Jefferson Medical College, Philadelphia
Type VI collagen defects in Bethlem myopathy |
| 10:55 am | Teri Klein, Stanford University, Stanford
Mutational effects on collagen's structure and stability |
| 11:10 am | Jouni Uitto, Jefferson Medical College, Philadelphia
Molecular genetics of PXE, the prototype of heritable connective tissue diseases |
| 11:45 am | Rick Wenstrup, Children's Hospital Research Foundation, Cincinnati
A pathogenic mechanism in classical Ehlers-Danlos syndrome (EDS) and partial explanation of the fibril diameter paradox |
| 12:00 am | General discussion. |
| 12:30 | LUNCH |
| 6:00 pm | CONFERENCE DINNER |
| 7:30 pm | BUSINESS MEETING |
|
| Discussion Leader: Karl Kadler, University of Manchester, U.K. |
| 7:50 pm | Karl Kadler: Introduction |
| 8:00 pm | Kathryn Chapman, University of Manchester, UK
Mutations in the von Willebrand factor A domain of matrilin-3 result in multiple epiphyseal dysplasia |
| 8:15 pm | Ichiro Sekiya, Tulane University, New Orleans
Sequential gene expression during differentiation to cartilage of human adult stem cells from bone marrow stroma |
| 8:30 pm | Jennifer Pierce-Tipper, University of New Mexico, Albuquerque
Regulation of sea cucumber inner dermis compliance properties by tensilin: a TIMP-like protein |
| 8:45 pm | Krisztina Rosenberg, University of Lund, Sweden
COMP acts in a chaperone fashion in collagen fibrillogenesis |
| 9:00 pm | Russell Fernandes, University of Washington, Seattle
Type II collagen N-propeptide processing by ADAMTS-3. Insights on dermatosparaxis |
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| 7:30 am | BREAKFAST |
| DEPARTURE |
