| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The Collagen Genome |
| Discussion Leader: Manuel Koch (University of Cologne) |
| Takeshi Iwatsubo (University of Tokyo)
A novel collagen associated with β-amyloid in Alzheimer's brains: CLAC-P/collagen type XXV |
| Jim Kramer (Northwestern University)
The C. elegans Collagenome |
| Ray Boot-Hanford (University of Manchester)
The evolution of fibrillar collagens - an incestuous family |
| James Pace (University of Washington)
Characterization and expression analysis of a new fibrillar collagen gene, COL27A1 |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | To Build a Matrix--Collagen Interactions |
| Discussion Leader: Dan Greenspan (University of Wisconsin) |
| Karl Kadler (University of Manchester)
Cellular aspects-the ins and outs-of extracellular matrix assembly |
| Leena Bruckner-Tuderman (University of Freiburg)
Type XVII collagen and shedases in cell interactions and matrix structure |
| 10:20 am | Group Photograph |
| Suneel Apte (Cleveland Clinic Research Foundation)
The ADAMTS proteases and their role in matrix assembly |
| William Pappano (University of Wisconsin)
Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to iIdentify and validate in vivo substrates of BMP-1/Tolloid-like metalloproteinases |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | POSTER SESSION 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Processing of Collagen Gene Transcripts |
| Discussion Leader: Leena Ala-Kokko (Tulane University, University of
Oulu) |
| Leena Ala-Kokko (Tulane University, University of
Oulu)
Introduction |
| Terry Gaasterland (Rockerfeller University)
Bioinformatic
approaches to alternative splicing in general and in collagen genes |
| Kathy Cheah (University of Hong Kong)
Functional roles of type
IIA procollagen |
| Ulrike Schwarze (University of Washington)
Order of intron
removal and effects of splice site mutations in collagen genes |
| John Bateman (University of Melbourne)
Tissue specificity of
nonsense mediated decay of abnormal collagen transcripts |
| General Discussion |
| POSTER SESSION 1, CONTINUED |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structure and Molecular Assembly of Procollagen Molecules |
| Discussion Leader: Hans-Peter Bächinger (Portland Shriners Hospital) |
| Kazuhiro Nagata (University of Kyoto)
HSP47 is essential for the molecular maturation of collagens and the formation of basement membranes |
| Ronald Raines (University of Wisconsin)
Hyperstable collagen mimics |
| Sergei Boudko (Biocentrum Basel)
Triple helix can form in either direction |
| David Hulmes (CNRS, Lyon)
α-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily
|
| Teri Klein (Stanford University)
Molecular dynamics modeling of mutations in type I collagen genes and their effects on folding and molecular structure |
| Kazunori Mizuno (Portland Shriners Hospital)
Analysis of peptides containing 4(R)-Hyp and 3(S)-Hyp in the Xaa position of Gly-Xaa-Yaa sequences |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Collagen-Related Post-Translational Processing Pathways |
| Discussion Leader: Johanna Myllyharju (University of Oulu) |
| Panu Jaakkola (University of Turku)
Sensing oxygen by HIF hydroxylation |
| Peppi Karppinen (University of Oulu)
Enzymatic properties of HIF prolyl 4 hydroxylases compared to those that modify collagens |
| Ruud Bank (Netherlands Organisation for Applied Scientific Research (TNO))
The substrate specificity of lysyl hydroxylase-1, 2 and 3: a story told by Ehlers-Danlos and Bruck syndrome patients |
| Raija Soininen (University of Oulu)
Characterization of mice with targeted
inactivation of lysyl hydroxylase-3, type I, or type II collagen prolyl-4-hydroxylase |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulated Expression of Collagen Genes |
| Discussion Leader: Kathy Cheah (University of Hong Kong) |
| Brendan Lee (Baylor College of Medicine)
Consequences of RUNX2 and LMX1B mutations on collagen gene expression |
| Benoit DeCrombrugghe (MD Anderson Cancer Center)
Collagen genes: prototypical targets of transcription factors that control cell lineages |
| Barbara D. Smith (Boston University)
Transcriptional repression of the COL1A2 gene by members of the RFX family of regulatory proteins |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | POSTER SESSION 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Collagen-Dependent Structure of Extracellular Matrix |
| Discussion Leader: David Birk (Thomas Jefferson University) |
| David Birk (Thomas Jefferson University)
Introduction |
| David Eyre (University of Washington)
Molecular interactions in
the cartilage matrix |
| Richard Wenstrup (Cincinnati Children's Hospital)
The role of
type V collagen in fibrillogenesis of the major fibrillar collagens |
| Susanne Grässel (University of Regensburg)
Type XVI collagen mediated interactions |
| Short Talk |
| General Discussion |
| POSTER SESSION 2, CONTINUED |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Collagen-cell interactions |
| Discussion Leader: Donald Gullberg (University of Upsala) |
| Bernhard Nieswandt (University of Würzburg)
α2β1 and GpVI functions in platelets revisited |
| Svetalana Popova (University of Uppsala)
The α11β1 integrin : a mesenchymal collagen receptor in search of in vivo function |
| Max Schneller (Cartela, Lund, Sweden)
Functional aspects of
integrin α10β1 |
| Johannes Eble (University of Münster)
Rhodocetin as a
collagen antagonist inhibits α2β1 integrin-mediated functions |
| Jyrki Heino (University of Turku)
The fibril-associated type IX collagen as a mediator of cell adhesion |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Hot topics selected from submitted abstracts |
| Discussion Leader: John Bateman (University of Melbourne) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
