SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Biosynthesis and Regulation of Collagens |
7:40 pm - 7:50 pm | Discussion Leader: Johanna Myllyharju (Oulu, Finland) "Introduction" |
7:50 pm - 8:15 pm | Hank Qi (Boston)
"Hydroxylation and Functional Impact of Human Argonaute 2 by Collagen Prolyl-4 Hydroxylase" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Hans Peter Bächinger (Portland)
"The P3H1/CRTAP/CypB Complex Has Multifunctional Roles in Collagen Biosynthesis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Larry Luchsinger (Boston)
"The Protein Arginine Methyltransferase (PRMT5) Associates with Class II Transactivator (CIITA) to Repress Collagen Transcription" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Paul Nerenberg (Cambridge)
"Partial Unfolding of the alpha2 chain in Type I Collagen as a Mechanism for Collagen Degradation" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Collagen Assembly |
| Discussion Leader: Hans-Peter Bächinger (Portland) |
9:00 am - 9:25 am | Sergei Boudko (Portland)
"Trimerization Domains of Collagens" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Yujia Xu (New York)
"Local Stability and the Conformational Changes of OI Mutations - a Look beyond the Propensity Scale" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break / Group Photo |
10:50 am - 11:15 am | Jeff Hartgerink (Houston)
"Design and Self-Assembly of Heterotrimeric Collagen Helices" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Joseph Orgel (Chicago)
"Collagen Fibril and Decorin Core Protein: Structure and Location of Interaction Sites" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Taina Pihlajaniemi (Oulu, Finland)
"Structural and Regulatory Roles of Endostatin Collagens at the Basement Membrane Zone" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collagen Receptors |
7:30 pm - 7:50 pm | Discussion Leader: Ambra Pozzi (Nashville)
"Overview on Collagen Binding Receptors and Their Cellular Functions" |
7:50 pm - 8:10 pm | Thomas Bugge (Bethesda)
"Collagen Remodeling in Tissue Development and Pathogenesis: the Endocytic Receptor uPARAP/Endo180" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Johanna Jokinen (Turku, Finland)
"Integrin alpha2beta1, a Collagen Receptor, Activates p38 MAP Kinase and PKC with Different Mechanisms" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Birgit Leitinger (London)
"How Discoidin Domain Receptors Interact with Collagen" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Brooke Russell (Houston)
"Prokaryotic Derived Collagen Like Proteins Demonstrate Specificity for Integrin Interactions" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen Suprastructures and ECM Ligand Interactions |
9:00 am - 9:10 am | Discussion Leader: David Birk (Tampa)
"Introduction" |
9:10 am - 9:35 am | Peter Bruckner (Muenster, Germany)
"Matrix Suprastructures: How the Same Proteomic Stars Play Distinct Games" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | James San Antonio (Malvern)
"Transforming the Two-Dimensional Collagen Map to the Living Fibril" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Ake Oldberg (Lund, Sweden)
"SLRPs Modulate Collagen Structure and Function" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Michael Yu (Baltimore)
"Spatio-Temporal Modification of Collagen Scaffolds Mediated by Collagen Mimetic Peptides" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Florence Ruggiero (Lyon)
"Collagen XXII is Required for Muscle Cell Attachment to Myoseptal Tendon in Zebrafish" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Karl Kadler (Manchester, UK)
"Towards an understanding of fibripositors - mechanosensors, 3D matrix adhesion or collagen-fibronectin fibrillogenesis sites?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ER Stress and Quality Control of Collagens |
7:30 pm - 7:45 pm | Discussion Leader: John Bateman (Melbourne, Australia) "Introduction" |
7:45 pm - 8:10 pm | Ray Boot-Handford (Manchester, UK)
"Targeted ER Stress Induces Chondrodysplasia" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Kathy Cheah (Hong Kong)
"Alleviating ER Stress in Chondrocytes: Molecular Strategies and the Developmental Cost of Recovery" |
8:50 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Tom Van Agtmael (Glasgow, UK)
"Spectrum of Phenotypes in Col4a1 Mutant Mice Includes Hypotension and Vasodilation Defects" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Fibroblasts and ECM Mechanoreception |
9:00 am - 9:10 am | Discussion Leader: Boris Hinz (Toronto, Canada)
"Introduction: Mechanics Matter" |
9:10 am - 9:35 am | Paul Janmey (Phildelphia)
"Matrix Stiffness: Integrating Cell Responses to Mechanical Stimuli" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Joachim Spatz (Stuttgart, Germany)
"How Fibroblasts Feel and Respond to Nano-Topographies" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Melody Swartz (Lausanne, Switzerland)
"Mechanical Cues in Three-Dimensional Collagen Matrices" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Kristofer Rubin (Uppsala, Sweden)
"Structure-Function Relationships in Carcinoma Stroma" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Lysianne Follonier-Castella (Lausanne, Switzerland)
"Calcium-Dependent Micro-Contractile Events in Myofibroblasts: Evidence for a Lock-Step Mechanism of Matrix Remodeling" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Functions of ECM in Stem Cell Niches |
7:30 pm - 7:45 pm | Discussion Leader: Marion Young (Bethesda)
"Introduction: Stem Cell Properties" |
7:45 pm - 8:05 pm | Xiao-Dong Chen (San Antonio)
"Reconstitution of Marrow-Derived Extracellular Matrix Ex Vivo: an Optimal Niche for Retaining Properties of Mesenchymal Stem Cells" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Sherrill Adams (Philadelphia)
"Decreased Type III Collagen Expression Impairs Mesenchymal Progenitor Cell Differentiation Toward Osteogenic and Chondrogenic Lineages and Alters Skeletal Development" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Jennifer Elisseeff (Baltimore)
"Biosynthetic Materials for Guiding Cel l and Tissue Repair" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Ching-Yan C. Yeung (Manchester, UK)
"Human Mesenchymal Stem Cells in Linear 3D Fibrin Gels Synthesize an Extracellular Matrix Similar to Embryonic Tendon" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen and ECM Diseases and Novel Therapeutic Strategies |
9:00 am - 9:10 am | Discussion Leader: Danny Chan (Hong Kong)
"Brief overview" |
9:10 am - 9:30 am | Doug Gould (San Francisco)
"Pleiotropism of Col4a1 Mutations Include Hallmarks of Muscle-Eye-Brain Disease" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Antti Salo (Oulu, Finland)
"LH3 Mutations in a Human Connective Tissue Disease" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Cassian Sitaru (Freiburg, Germany)
"Autoimmunity Against Collagens of the Epidermal Basement Membrane" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:05 am | Manuel Koch (Cologne, Germany)
"Skeletal Phenotypes of Collagen XII / XIV Mutations in Mouse and Man" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Dan Greenspan (Madison)
"New Roles for Type V Collagen in Metabolism and Disease" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Markus Moser (Martinsried, Germany)
"The Tale of Kindlins" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Joan Marini (Bethesda)
"COL1 C-propeptide Cleavage Site Mutations Cause OI with Increased Bone Mineralization" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Hot Topics |
| Discussion Leader: Billy Hudson (Nashville) |
7:30 pm - 7:50 pm | Matthew Hoffman (Bethesda)
"MT2-MMP-dependent Release of NC1 Domains from Collagen IV Regulates Protease Expression and Epithelial Proliferation during Morphogenesis" |
7:50 pm - 8:00 pm | Discussion |
8.00 pm - 8:20 pm | Roberto Vanacore (Nashville)
"Identification of a Novel Sulfur Bond in the Hydroxylysine/Methionine Crosslink of Collagen IV" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Michael Fox (Richmond)
"Collagen XVII is required for Synapse Formation in the Mammalian Central Nervous System" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Leena Bruckner-Tuderman (Freiburg)
"Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa" |
8:55 pm - 9.00 pm | Discussion |
9.00 pm - 9:10 pm | Jarmo Käpylä (Turku)
"A Small Molecule Inhibitor of Integrin Alpha2Beta1 Introduces a New Strategy for Antithrombotic Therapy" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Nishad N. Fathima (Tamil Nadu)
"Structure and Hydration Dynamics of Collagen and its Influence on Adhesion and Dilation at Interfaces" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |