SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Past and Future of Cell-Matrix Research: A Debate |
| Discussion Leader: Karl E. Kadler (University of Manchester) |
7:40 pm - 7:45 pm | Chair: Billy G. Hudson (Vanderbilt University) "Welcome / Introduction" |
7:45 pm - 7:50 pm | Karl E. Kadler (University of Manchester)
"Introduction" |
7:50 pm - 8:00 pm | Arthur Veis (Northwestern University)
"Collagen: Structure before the triple helix" |
8:00 pm - 8:10 pm | Darwin Prockop (Texas A&M)
"How can we achieve a working model for matrix cell interactions?" |
8:10 pm - 8:20 pm | John Fessler (UCLA)
"My Collagen Acquaintance: From Tanning of Cow Hides to the Flourishing of Fruit Flies" |
8:20 pm - 8:30 pm | Lisa Fessler (UCLA)
"Interaction Views of a Drosophila ADAMTS protease (Abigail) with ECM Proteins" |
8:30 pm - 9:30 pm | Debate |
9:30 pm - 10:30 pm | Reception to celebrate 40 years of collagen research |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Technologies in Cell Matrix Biology |
| Discussion Leader: Sarah Dallas (UMKC) |
9:00 am - 9:20 am | Sarah Dallas (UMKC)
"Collagen-GFP constructs for imaging of collagen in vitro and in transgenic mice" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Richard Caprioli (Vanderbilt University)
"Imaging Mass Spectrometry: New Views of Biology and Medicine" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Richard Farndale (University of Cambridge)
"Probing protein interactions with collagen using the Toolkits: synthetic triple-helical peptide libraries" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Peter Friedl (Nijmegen Centre for Molecular Life Sciences)
"3D cell invasion into collagen-rich tissue: molecular and physical determinants" |
11:50 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Erhard Hohenester (Imperial College London)
"Longer is better: crystal structure of MMP-1 bound to a triple-helical collagen peptide" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mechanotransduction in Tissue Organization |
| Discussion Leader: Chris McCulloch (University of Toronto) |
7:30 pm - 7:45 pm | Chris McCulloch (University of Toronto)
"Introduction" |
7:45 pm - 8:05 pm | Paul Janmey (University of Pennsylvania)
"Adhesion receptor-specific responses to matrix stiffness" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Boris Hinz (University of Toronto)
"Mechanical stress liberates pro-fibrotic TGFβ1 from extracellular matrix repositories: a single molecule study" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Donald Gullberg (University of Bergen)
"The role of the mechanosensing integrin a11b1 in tumor stroma interactions" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen Assembly and Processing |
| Discussion Leader: Collin Stultz (Massachusetts Institute of Technology) |
9:00 am - 9:10 am | Collin Stultz (Massachusetts Institute of Technology)
"Introduction" |
9:10 am - 9:30 am | David Hulmes (Institut de Biologie et Chimie des Protéines)
"Procollagen proteinases, collagen assembly and corneal repair" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Joanne Murphy-Ullrich (University of Alabama-Birmingham)
"Calreticulin regulation of fibrillar collagen" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | David Birk (University of South Florida)
"Regulation of tendon extracellular matrix assembly" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Nicholas Kalson (University of Manchester)
"Cell-force based collagen remodeling during tendon development" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Jeffrey W. Ruberti (Northeastern University)
"Multiscale collagen mechanochemistry" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collagen Ligands and Receptors |
| Discussion Leader: Linda Sandell (Washington University) "Control of angiogenesis in cartilage by type II collagen N-propeptide via Integrins avB3
and avB5" |
7:30 pm - 7:50 pm | Linda Sandell (Washington University)
"Control of Angiogenesis by Type II collagen N-propeptide via Integrins avB3 and avB5" |
7:50 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Johannes Eble (Frankfurt University Hospital)
"Switching on and off collagen-binding integrins" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Peter Chen (University of Washington)
"Syndecan-1 regulation of a2b1 integrin activation in the lung epithelium" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | GRS Speaker: Szymon Manka (Imperial College London) "Cooperative hydrophobic interactions between collagen and collagenase trigger collagen unwinding" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagens in Model Organisms |
| Discussion Leader: Florence Ruggiero (Institut de Biologie et Chimie des Protéines, France) |
9:00 am - 9:20 am | Florence Ruggiero (Institut de Biologie et Chimie des Protéines)
"Deficiency of the myotendinous junction component collagen XXII causes severe muscular dystrophy in zebrafish" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | David Sherwood (Duke University)
"Subcellular mechanisms underlying basement membrane transmigration: Anchor cell invasion in C. elegans" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Gautam (Jay) Bhave (Vanderbilt University)
"Mechanism of Sulfilimine Cross-Link Formation in the Animal Kingdom" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Helen Skaer (University of Cambridge)
"Collagen enhances signalling for renal development in Drosophila" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Sally Horne-Badovinac (University of Chicago) "Collagen IV Secretion and Remodeling during Epithelial Morphogenesis in Drosophila" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jose Pastor-Pareja (Yale School of Medicine) "Shaping cells and organs in Drosophila through the opposing effects of fat body-
secreted collagen IV and perlecan" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Transcriptional and Epigenetic Regulation of Collagen |
| Discussion Leader: Taina Pihlajaniemi (University of Oulu) |
7:30 pm - 7:40 pm | Taina Pihlajaniemi (University of Oulu)
"Introduction" |
7:40 pm - 8:00 pm | Chris Murphy (Imperial College London)
"Transcriptional and microRNA-mediated Regulation of Type II Collagen Expression" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Rama Natarajan (Beckman Research Institute of City of Hope)
"Role of microRNAs in TGF-beta1 induced regulation of Collagen. Relevance to Diabetic Nephropathy" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Barbara Smith (Boston University) "Transcription regulators of collagen during wound healing" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | GRS Speaker: Ming Fang (Univ. of Michigan) "The origin of dermis collagen matrix nanomorphology and its relationship with estrogen depletion" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STEM Cells and Regenerative Medicine |
| Discussion Leader: Karl Tryggvason (Karolinska Institute) |
9:00 am - 9:20 am | Karl Tryggvason (Karolinska Institute)
"Laminins - extracellular Modulators of Cellular Phenotypes" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Huansheng Xu (Massachusetts General Hospital) "Epigenetic control of efficient ventricular myocyte differentiation from pluripotent stem cells" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Masaki Ieda (Keio University)
"Direct Reprogramming of Fibroblasts to Cardiomyocytes" |
10:50 am - 11:05 am | Discussion |
11:05 am - 11:25 am | Samuel Stupp (Northwestern University)
"Supramolecular Design of Artificial Extracelllular Matrices" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Chang Hun Lee (Columbia University)
"Regeneration by Endogenous Cell Homing" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | GRS Speaker: Fei Xu (Univ. of Medicine and Dentistry of New Jersey) "Computationally modeled self-assembly of higher order structure of collagen peptides" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture |
7:30 pm - 9:00 pm | Kevin P. Campbell (University of Iowa)
"Glycobiology and Cell-Matrix Interactions: Insights from Dystroglycan Function" |
9:00 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |