SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Chair Karl Kadler (University of Manchester, UK) |
7:40 pm - 9:30 pm | Emerging Technologies in Cell-Matrix Research |
7:40 pm - 8:00 pm | Discussion Leader: John Bateman (Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia)
"Introductory Remarks" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Martin Humphries (University of Manchester, UK)
"What's in an adhesion complex, and how does it work?"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Melinda Duer (University of Cambridge, UK)
"Heavy mice and lighter things: using NMR spectroscopy to elucidate molecular structures in tissues"
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9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Bo An (Tuffs University, Boston)
"Investigation of a protein binding hotspot from human collagen using recombinant bacterial collagen"
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9:25 pm - 9:30 pm | Discussion |
9:30 pm - 10:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen Biosynthesis, Structure and Assembly |
9:00 am - 9:20 am | Discussion Leader: David Hulmes (Institute for the Biology and Chemistry of Proteins, Lyon, France)
"Introductory Remarks: Mystery of procollagen trimerization revealed" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | David Eyre (University of Washington, Seattle)
"Prolyl 3-hydroxylation, molecular assembly and cross-linking"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Michael Rape (University of California, Berkeley)
"Ubiquitin-dependent regulation of collagen secretion"
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10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Peter Bruckner (University Hospital of Münster, Germany)
"Corneal morphogenesis depends on covalent collagen cross-linking"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, Napes, Italy)
"Role of TRAPP complex in procollagen trafficking"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Mark Banaszak Holl (University of Michigan)
"Type I collagen fibrils, the D-periodic axial spacing, and microscale order: connections to estrogen-related Disease"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Claudia Broder (University of Kiel, Germany)
"It's make or break: the metalloproteases meprin α and meprin β are C- and N-procollagen proteinases resulting in an Ehlers-Danlos syndrome-like phenotype in Mep1a-/- and Mep1b-/- mice"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collagen-Protein Interactions and Signaling |
7:30 pm - 7:50 pm | Discussion Leader: Hilary Ashe (University of Manchester, UK)
"Introductory Remarks" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Amy Bradshaw (Medical University of South Carolina)
"Procollagen processing in hearts and periodontal ligament - collagen-binding proteins that affect fibril assembly and deposition"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Antti Salo (University of Oulu, Finland)
"Collagen prolyl 4-hydroxylases in skeletogenesis"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Christopher Cummings (Vanderbilt University, Nashville, TN)
"Collagen IV sulfilimine chemistry: mechanism and essentiality"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Abhishek Anan (Rice University)
"Tackling diverse problems in the design of collagen mimetic peptides with salt-bridge interaction" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Developmental Biology of the Matrix |
9:00 am - 9:20 am | Discussion Leader: Ronen Schweitzer (Shriners Research Center, Portland, OR)
"Introductory Remarks" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Elazar Zelzer (Weizmann Institute of Science, Israel)
"Building the bone-tendon attachment unit"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | David Birk (University of South Florida)
"Regulation of extracellular matrix assembly during development"
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10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Group Photo / Coffee Break |
10:55 am - 11:15 am | Delphine Duprez (Université Pierre et Marie Curie, Paris, France)
"Transcription and growth factors during tendon formation and repair"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Audrey McAlinden (Washington University, St. Louis)
"Mis-expression of embryonic Col2a1 isoforms affects cartilage matrix assembly and post-natal bone development"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Adam Isabella (University of Chicago)
"Basement membrane remodeling during organ morphogenesis in Drosophila"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Veronique Van de Bor (University of Nice, France)
"Origin, assembly and function of Collagen IV in the Drosophila ovary" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic Mechanisms of Disease |
7:30 pm - 7:50 pm | Discussion Leader: Leena Bruckner-Tuderman (Freiburg Institute for Advanced Studies, Germany)
"Introductory Remarks" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Qing Jun Meng (University of Manchester, UK)
"Circadian rhythms of matrix-secreting cells"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Cristina Has (University of Freiburg, Germany)
"Focal adhesions and skin fragility disorders"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Fransiska Malfait (University of Ghent, Belgium)
"Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic connective tissue disorder related to Ehlers-Danlos syndrome"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Tom Van Agtmael (University of Glasgow, UK)
"Chemical chaperone treatment ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke by reducing intracellular accumulation of collagen IV"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen Regulation and Dysregulation |
9:00 am - 9:20 am | Discussion Leader: Sergey Leikin (National Institute of Child Health & Human Development, NIH)
"Introductory Remarks" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Peter Byers (University of Washington, Seattle)
"Lessons learned: cis- and trans-acting effects on collagen production and structure identified from heritable disorders"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Kazuhiro Nagata (Kyoto Sangyo University, Japan)
"Regulation of collagen synthesis by Hsp47 and P4H in combination with specific inhibitors"
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10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Joan Marini (NICHD, NIH)
"Identification of a causative mutation for bone dysplasia"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Giorgio Galli (Boston Children's Hospital)
"Prdm5-dependent regulation of collagen genes transcription"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Ulrich Baumann (University of Cologne, Germany)
"A structural basis for the mechanism of the collagen-specific chaperone serpinH1/Hsp47"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Inna Solomonov (Weizmann Institute of Science, Israel)
"Critical Role of Collagenases in Fine Tuned Native Collagen degradation"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Stem Cells, Repair and Regenerative Medicine |
7:30 pm - 7:50 pm | Discussion Leader: Pamela G. Robey (NIDCR, NIH)
"Introductory Remarks" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Fiona Watt (King's College London, UK)
"Dermal remodelling mediated by epidermal signals"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Matthias Lutolf (Swiss Federal Institute of Technology Lausanne (EPFL))
"Deciphering stem cell-ECM interactions using artificial niches"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Hanne-Kaisa Honkanen (University of Oulu, Finland)
"Collagen XVIII regulates lymphangiogenesis and tumor multiplicity in a chemical mouse skin carcinogenesis model"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Chloé Yeung (University of Manchester, UK)
"Regulation of BMP signaling by the tendon peripheral clock" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Matrix Mechanobiology |
9:00 am - 9:20 am | Discussion Leader: Boris Hinz (University of Toronto, Canada)
"Introductory Remarks: Fibroblasts and the art of re-modeling" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Thomas Cox (BRIC, University of Copenhagen, Denmark)
"Lysyl oxidases in cancer progression"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Michael Kjaer (Bispebjerg Hospital, Copenhagen, Denmark)
"Mechanical loading and collagen turnover in tendon and skeletal muscle - how dynamic is it?"
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10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Dennis Discher (University of Pennsylvania, PA)
"From matrix to nucleus - Scaling results in polymer biophysics"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Valerie Weaver (UC Berkeley/UCSF) |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Cedric Zeltz (University of Bergen, Norway)
"Integrin α11β1: a major mechanosensitive / mechanotransducing collagen receptor in fibroblasts"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Michael Paukshto (Fibralign Corporation, Sunnyvale, CA)
"Control of cellular migration, survival and gene expression on patterned collagen fibers"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Future Directions of Collagen Matrix Research |
7:30 pm - 7:50 pm | Discussion Leader: Collin Stultz (Harvard-MIT Division of Health Sciences and Technology)
"Introductory Remarks" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Shireen Lamandé (Murdoch Childrens Research Institute, Melbourne, Australia)
"Collagen VI in cartilage - a structural or signaling molecule?"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Markus Buehler (Massachusetts Institute of Technology)
"In silico mechanobiology of collagen: mutations, defects and mechanics"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Susanta Sarkar (NHLI, NIH)
"MMP9 modulates the interactions of MMP1 with type I collagen fibrils"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Michael Randles (University of Manchester, UK)
"Gender and genetic background influence the composition of glomerular extracellular matrix" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |