Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Expression and Regulation of Collagen Genes and Gene Network |
| Discussion Leader: Barbara Smith (Boston University School of Medicine, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:00 pm | Introduction by Discussion Leader |
8:00 pm - 8:20 pm | Barbara Smith (Boston University School of Medicine, USA) "Myocardin Related Transcription
Factor A (MRTF-A/MKL1): From Actin Dynamics to Epigenetic Activation of
Collagen Transcription in Fibrotic Diseases" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | George Bou-Gharios (University of Liverpool, United Kingdom) "Collagen
Type I Regulation and Its Relationship to Fibrotic Disease" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Michael Czubryt (University of Manitoba, Canada) "Scleraxis: A Novel Transcriptional Regulator of Cardiac Fibroblast Phenotype and Extracellular Matrix Production" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structure and Function of Different Domains in
Collagen Molecules |
| Discussion Leader: Barbara Brodsky (Tufts University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Barbara Brodsky (Tufts University, USA) "Nature of the Interaction
Between Collagen and Fibronectin and Its Disruption by Mutations" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Jean Baum (Rutgers University, USA) "The Collagen Triple Helix: Structural Features
and Biological Implications" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Joshua Sakon (University of Arkansas, USA) "Structure, Targeting Mechanism and Preclinical Use of Clostridial
Collagen Binding Proteins" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Erhard Hohenester (Imperial College London, United Kingdom) "Structural Insights into Collagen Uptake by
C-Type Mannose Receptors" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Andrew Dittmore (National Institutes of Health, USA) "Fluctuating Structural Features of Collagen Revealed by Enzyme Binding" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Raimund Wagener (University of Cologne, Germany) "Structural Analysis of Collagen VI Non-Collagenous Domains" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collagen Homeostasis |
| Discussion Leader: Karl Kadler (University of Manchester, United Kingdom) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Karl Kadler (University of Manchester, United Kingdom) "Rhythmic
Control of Collagen Synthesis and Degradation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Johanna Myllyharju (University of Oulu, Finland) "Prolyl 4-Hydroxylases, Key Enzymes in Synthesis of
Collagens and Regulation of Hypoxia Signaling" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Anita Capalbo (Institute of Protein Biochemistry, CNR, Italy) "Signaling Circuits Regulate Procollagen Exit from the Endoplasmic Reticulum: Implications for the Therapy of Collagenopathies" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Yoshihiro Ishikawa (Shriners Hospitals Portland, USA) "Identification of a Guide Molecule in the rER to Direct Collagens Toward Special Transport Vesicles" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagens in Basement Membranes |
| Discussion Leader: Taina Pihlajaniemi (University of Oulu, Finland) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Taina Pihlajaniemi (University of Oulu, Finland) "Collagen XVIII: Isoforms with Distinct Roles at
the Basement Membrane-Cell Interphase" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Leena Bruckner-Tuderman (University of Freiburg, Germany) "Molecular Defects of Epidermal Basement
Membrane: Mechanisms and Therapeutic Targets" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Group Photo / Coffee Break |
10:40 am - 11:00 am | Antonio Santos (Center for Genomic Regulation, Spain) "TANGO1 Recruits ERGIC Membranes to ER Exit Sites to Allow Bulky Procollagen VII Secretion" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Sally Horne-Badovinac (University of Chicago, USA) "Spinning the Matrix: Basement Membrane Secretion and Remodeling
During Organ Morphogenesis" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Muriel Grammont (ENS de Lyon, France) "Role of the Stiffness of the Basement Membrane for Epithelial Morphogenesis in Drosophila" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Alexander Nystrom (University Medical Center Freiburg, Germany) "Collagen VII Expressed in Splenic Conduits Regulates Innate Immunity and Clearance of Bacteria" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collagens in Cell Niche and Cell Signaling |
| Discussion Leader: Paolo Bonaldo (University of Padova, Italy) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Paolo Bonaldo (University of Padova, Italy) "Collagen VI Is a Key Component of Satellite Cell
Niche Required for Muscle Regeneration" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Veronique Van De Bor (Institute of Biology Valrose, University Nice Sophia-Antipolis, France) "Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Adam Engler (University of California, San Diego, USA) "Niche Dynamics Promote Epithelial-Mesenchymal Transition via Mechanical Signaling" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Georgios Theocharidis (Blizard Institute, Barts and The London School of Medicine and Dentistry, United Kingdom) "Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagens in Organism Physiology |
| Discussion Leader: Daniel Greenspan (University of Wisconsin, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Daniel Greenspan (University of Wisconsin, USA) "Type
V Collagen Microenvironments Instruct the Behavior of Highly Specialized Cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Tomoko Wakabayashi (University of Tokyo, Japan) "Roles
in Neuromuscular Development of CLAC-P/Collagen Type XXV: A Molecule Originally
Identified in Alzheimer Brains" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Michael Fox (Virginia Tech Carilion Research Institute, USA) "Collagen XIX Contributes to Inhibitory Synapse
Formation and Complex Brain Disease" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Keith Blackwell (Harvard Medical School, USA) "Importance of Collagen Remodeling for Lifespan
Extension" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Christopher Cummings (Vanderbilt University Medical Center, USA) "Dual Halide Mechanism for
the Assembly of Collagen IV Scaffolds in Basement Membranes" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Sandrine Bretaud (Institut de Genomique Fonctionnelle de Lyon, France) "Slow Muscle Precursors Lay Down a Collagen XV-B Matrix Fingerprint that Participates in Motor Axon Navigation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Collagens in Pathology |
| Discussion Leader: Bjorn Olsen (Harvard School of Dental Medicine, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Bjorn Olsen (Harvard School of Dental Medicine, USA) "Novel Insights into Regulatory Mechanisms in Connective Tissues" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Shireen Lamande (Murdoch Childrens Research Institute, Australia) "A New Collagen I
Phenotype and a Novel Recessive COL1A1 Mutation Identified by Next Generation
Sequencing" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Stefan Schulte-Merker (Hubrecht Institute, Germany) "The Key Role of a Collagen-Repeat Domain in Hennekam Syndrome Patients" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Marion Gordon (Rutgers University, Ernest Mario School of Pharmacy, USA) "Collagen XXIV in Bone" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Collagen Based Materials and Bioengineering |
| Discussion Leader: Rocky Tuan (University of Pittsburgh, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Rocky Tuan (University of Pittsburgh, USA) "Biomimetic Scaffolds for 3-Dimensional Tissue Engineering and Modeling" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Jean Chmielewski (Purdue University, USA) "Hierarchical Assembly of Collagen Peptide-Based
Materials for Use in Regenerative Medicine" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Ronald Raines (University of Wisconsin - Madison, USA) "Longer,
Stronger Synthetic Collagens for Nanotechnology and Biomedicine" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Gregg Fields (Florida Atlantic University, USA) "In Vivo Inhibition of MMP Activity Using Collagen-Model, Triple-Helical Peptides" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Abeni Wickham (Linkoping University, Sweden) "Collagen Silver Nanowire Nanocomposites as Electrically Active Scaffolds for Embryonic Cardiac Cell Proliferation" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Josephine Morris (University of Bristol, United Kingdom) "Generation of a GFP Labelled Collagen I Transgenic Zebrafish to Enable Live Imaging Wound Healing Studies" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Aaron Fidler (Vanderbilt University Medical Center, USA) "Ctenophora and the Evolutionary Dawn of Collagens and Tissues" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Collagenopathies of Skeletal Muscle / Late-Breaking Topics |
| Discussion Leader: Shireen Lamande (Murdoch Childrens Research Institute, Australia) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:15 pm | Carsten Bonnemann (National Institutes of Health, USA) "Muscle Meets Its Matrix: Collagenopathies of
Skeletal Muscle" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Joan Marini (Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, NIH, USA) "Absence of ER Cation Channel TMEM38B: A New Mechanism for Recessive OI" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Matthew Shoulders (Massachusetts Institute of Technology, USA) "Leveraging the Unfolded Protein Response to Enhance Collagen-I Proteostasis" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Uwe Hansen (University Hospital Muenster, Germany) "Collagen Binding Integrins (a1b1, a2b1, and a10b1) Bind to Monomeric Collagens but Not to Collagens Aggregated into Fibrils" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Bjorn Olsen (Harvard School of Dental Medicine, USA) "Matrix Phosphorylation" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |