Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: LAMA2-Deficient Muscular Dystrophy / Skin Stem Cell Homeostasis and Regeneration
Discussion Leader: Leena Bruckner-Tuderman (University Medical Center Freiburg, Germany)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Peter Yurchenco (Robert Wood Johnson Medical School, Rutgers University, USA)
"Linker Protein Repair of LAMA2-Deficient Muscular Dystrophy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Matt Marinkovich (Stanford University School of Medicine, USA)
"Gene Therapy for Epidermolysis Bullosa"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Joanna Jackow (Columbia University, USA)
"Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Alexander Nystrom (University Medical Center Freiburg, Germany)
"Analysis of Microfibril Architecture in Dystrophic Epidermolysis Bullosa Skin Reveals Novel Mechanisms of Fibrosis-Related Extracellular Matrix Assembly"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagen Transport and Trafficking
Discussion Leader: Karl Kadler (University of Manchester, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Vivek Malhotra (Centre for Genomic Regulation, Spain)
"Mechanism of Collagen Secretion"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Sergey Leikin (National Institutes of Health, USA)
"Procollagen Sorting at ER Exit Sites"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Niels Behrendt (Finsen Laboratory, Denmark)
"The Endocytic Collagen Receptor uPARAP/Endo180 as a Novel Therapeutic Target in Mesenchymal Cancers"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Qing-Jun Meng (University of Manchester, United Kingdom)
"Circadian Clocks in Health and Disease of the Musculoskeletal System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
David Stephens (University of Bristol, United Kingdom)
"Intracellular Trafficking and Processing of Type I Procollagen"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Nicola Stevenson (University of Bristol, United Kingdom)
"Giantin Is Required for Intracellular N-Terminal Processing of Procollagen Type I"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Brecht Guillemyn (Center for Medical Genetics Ghent (CMGG), Belgium)
"OASIS on the Move: Elucidation of the Molecular Cause Underlying CREB3L1-Related Osteogenesis Imperfecta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Joan Marini (National Institute of Child Health and Human Development, NIH, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioengineering for Repair of Function
Discussion Leader: Joseph Orgel (Illinois Institute of Technology, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
James Zieske (Schepens Eye Research Institute / Massachusetts Eye and Ear, USA)
"Role of Exosomes on Corneal Wound Healing"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Dimitrios Zeugolis (National University of Ireland Galway, Ireland)
"Rebuilding the Matrix in a Crowded Milieu"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Joseph Freeman (Rutgers University, USA)
"The Use of Collagen Methacrylate in Actuating Polyethylene Glycol Diacrylate-Acrylic Acid Scaffolds for Muscle Regeneration"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Orit Shefi (Bar-Ilan University, Israel)
"Orienting Collagen In Situ as a Regenerative Scaffold for Neuronal Regrowth"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Treatment and Diagnosis of Matrix Diseases
Discussion Leader: Sergey Leikin (National Institutes of Health, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Leena Bruckner-Tuderman (University Medical Center Freiburg, Germany)
"System Involvement in Epidermolysis Bullosa: Consequences for Evidence-Based Therapies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Bjorn Olsen (Harvard School of Dental Medicine, USA)
"A Case of Mechanistic Insights Defining Treatment and Diagnosis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Valerio Izzi (University of Oulu, Finland)
"From the Bytes to the Bedside: The Role of Collagen XVIII in Normal and Malignant Hematopoiesis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:15 am
Rachel Lennon (Wellcome Trust Centre for Cell-Matrix Research, United Kingdom)
"Basement Membrane Gene Defects Associate with an Increasing Spectrum of Kidney Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Jean Baum (Rutgers University, USA)
"Molecular Underpinnings of Collagen Interactions in the ECM in Health and Disease"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Delfien Syx (Ghent University, Belgium)
"Aberrant Binding of Mutant HSP47 to Type I Collagen Results in Severe Osteogenesis Imperfecta"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Alexander Brodsky (Rhode Island Hospital / Brown University, USA)
"Somatic Mutations in Collagens Are Associated with Overall Survival and Impact Tumors"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cartilage and Bone Disease
Discussion Leader: Mary Ann Stepp (George Washington University School of Medicine and Health Sciences, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"Unraveling the Cell and Molecular Bases of Intervertebral Disc Degeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Joan Marini (National Institute of Child Health and Human Development, NIH, USA)
"The Intersection of Types V and VI OI in Patients and Mice"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Gregg Fields (Florida Atlantic University, USA)
"Further Consideration of the Role of Matrix Metalloproteinase 13 in Matrix Diseases"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Charlotte Gistelinck (University of Washington, USA)
"Cross-Linked Collagen Peptides as a Non-Invasive Urinary Biomarker of Bone Quality in Patients with Osteogenesis Imperfecta"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens of the Basement Membrane Zone
Discussion Leader: Johanna Myllyharju (University of Oulu, Finland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Billy Hudson (Vanderbilt University, USA)
"Halogens Are Essential for Building Collagen IV Smart Scaffolds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
David Sherwood (Duke University, USA)
"Construction of a Basement Membrane Toolkit in C. elegans : Stoichometry, Turnover and Growth Revealed"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Mia Rinta-Jaskari (University of Oulu, Finland)
"Collagen XVIII Regulates Nephron Progenitor Cell Fate and Is Crucial for Branching Morphogenesis During Kidney Development"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Florence Ruggiero (ENS de Lyon / UMR5242, CNRS, France)
"Basement Membrane Zone Collagens in the Development and Function of the Zebrafish Neuromuscular System"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Douglas Gould (UCSF School of Medicine, USA)
"Therapeutic Implications of Tissue Specific Mechanistic Heterogeneity in COL4A1 Syndrome"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Tom Van Agtmael (University of Glasgow, United Kingdom)
"Material-Driven Fibronectin Assembly Affects Patient Cells Harbouring a Collagen IV Mutation"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Pinyuan Tian (The University of Manchester, United Kingdom)
"Modelling Alport Syndrome Using Patient-Derived iPSCs"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Wound Healing
Discussion Leader: Qian Chen (Rhode Island Hospital / Brown University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Mary Ann Stepp (George Washington University School of Medicine and Health Sciences, USA)
"Studying the Cornea to Understand Regenerative Repair"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Balaraman Madhan (Anna University / CSIR-Central Leather Research Institute, India)
"Collagen Composites for Tissue Engineering Applications"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Kathy Svoboda (Texas A&M College of Dentistry, USA)
"Gelatin Based Scaffolds and Injectable Substrates for Wound Healing"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Bassil Dekky (University of Pennsylvania School of Veterinary Medicine, USA)
"Role of Type III Collagen in the Breast Cancer Microenvironment"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanical Tissue Properties: Collagens in Aging
Discussion Leader: Billy Hudson (Vanderbilt University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Rajiv Mohan (University of Missouri, USA)
"Collagens in Aging Corneal Wound"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Clair Baldock (University of Manchester, United Kingdom)
"Mechanism of Collagen VI Microfibril Assembly Revealed by Cryo-Electron Microscopy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Nancy Forde (Simon Fraser University, Canada)
"Collagen Mechanics Investigated with Single-Molecule Techniques"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Qian Chen (Rhode Island Hospital / Brown University, USA)
"Inhibiting Cell Senescence for Treating Injury and Aging Associated Osteoarthritis"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Ming Pei (West Virginia University, USA)
"Matrix Microenvironment and Stem Cell Fate Determination"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Karanvir Saini (University of Pennsylvania, USA)
"Heterogeneously Strained Tissue Collagen Resists Collagenase Degradation Where Strains Are High"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jerome Janssen (University Medical Center Göttingen, Germany)
"Chondrogenic Progenitor Cells Regulate Collagen Types I and II in the Regeneration of Cartilage Tissue"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modifications of Collagens
Discussion Leader: Bjorn Olsen (Harvard School of Dental Medicine, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Johanna Myllyharju (University of Oulu, Finland)
"Key Collagen Synthesis Enzymes and ECM Homeostasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Joseph Orgel (Illinois Institute of Technology, USA)
"Collagen Fibril Modifications for Function and in Pathology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Geert Carmeliet (KU Leuven, Belgium)
"Cell Metabolism Regulates Collagen Synthesis and Hydroxylation"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Yoshihiro Ishikawa (University of California, San Francisco, USA)
"Re-Evaluation of Lysyl Hydroxylation in the Collagen Triple Helix Regarding Site Preference and Type Specific Activities"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
