Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: ECM Dynamics in Development and Disease
Discussion Leader: Tom Van Agtmael (University of Glasgow, United Kingdom)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Irit Sagi (The Weizmann Institute of Science, Israel)
"The Role of Mucosal Collagens in Perpetuating Chronic Inflammation in Inflammatory Bowel Disease"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Ernestina Schipani (University of Pennsylvania, United States)
"How Hypoxia Shapes up Skeleton Development"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Maryline Fresquet (University of Manchester, United Kingdom)
"A Role for Collagen VII in Autoimmune Kidney Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Angus Nichols (King's College London, United Kingdom)
"Investigating Basement Membrane Dynamics and Maturation During Drosophila Development"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Effects and Translational Potential of Mutations in Collagens
Discussion Leader: Florence Ruggiero (ENS de Lyon / CNRS, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Billy Hudson (Vanderbilt university medical center, United States)
"Essentiality of the Collagen Triple Helix in Evolution"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Fransiska Malfait (Ghent University Hospital, Belgium)
"Pain Mechanisms in Heritable Collagen Disorders: Lessons Learned from the Ehlers-Danlos Syndromes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Kathryn Yammine (Massachusetts Institute of Technology, United States)
"Elucidating Pathologic Mechanisms in the COL2A1 Gly1170Ser-Induced Collagenopathy Using an iPSC-Based Cartilage Model"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Paolo Bonaldo (University of Padova, Italy, Italy)
"Novel Tools for Drug Repurposing in COL6-Related Myopathies: Accelerating the Route Towards Therapy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Hiro Uehara (University of Oregon, United States)
"CRISPR/Cas9 Gene Therapy Prevents Murine Col8a2 Mutated Fuchs' Endothelial Corneal Dystrophy"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Elena Makareeva (National Institutes of Health, United States)
"Distinct Molecular Mechanisms of Bone and Lung Pathologies in a G610C Mouse Model of Osteogenesis Imperfecta"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Antti Salo (University of Oulu, Finland)
"Substrate Specificity and Functions of Collagen Prolyl 4-Hydroxylase Isoenzymes"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Rachel Lennon (Wellcome Centre for Cell-Matrix Research, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Collagen Transport, Turnover and Homeostasis
Discussion Leader: Yoshihiro Ishikawa (University of California, San Francisco, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Suneel Apte (Cleveland Clinic, United States)
"Degradomic Insights on the Complex Regulation of Collagen Turnover"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Chloé Yeung (Institute of Sports Medicine Copenhagen, Denmark)
"Diurnal Regulation of Collagen Homeostasis in Human Tendons"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Federico Forneris (University of Pavia, Italy)
"Molecular Structures of Human Collagen Lysyl Hydroxylases and Glycosyltransferases"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Mao Mao (University of California, San Francisco, United States)
"Development of a Novel Mouse Model Carrying a Multifunctional Col4a1 Tagged Allele"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens and Related Molecules in Stem Cell Regulation
Discussion Leader: Leena Bruckner-Tuderman (Medical Center - University of Freiburg, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Cell Fate by Mechanical Forces"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Hironobu Fujiwara (RIKEN Center for Biosystems Dynamics Research, Japan)
"Multicellular and ECM Dynamics Underlying Skin Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:00 am
Danny Chan (The University of Hong Kong, Hong Kong SAR China)
"ECM in Planarian Stem Cell Niche and Regeneration"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Rana Ramadan (Amsterdam UMC, The Netherlands)
"The Extracellular Matrix and It’s Role in Intestinal Stem Cell Regulation and Crypt Morphology"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Colin Trepicchio (Tufts University, United States)
"Exploring the Significance of Collagen Signaling in Mammary Gland Morphogenesis and 3D Tissue Development"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Manu Unni (Weizmann Institute of Science, Israel)
"Rethinking Hydra Regeneration: A Role for ECM Stiffness."
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Philippos Mourikis (East-Paris University / Mondor Institute, France)
"Regulation of the Muscle Stem Cell ECM by Notch Signalling"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioengineering and Materials Design
Discussion Leader: Nancy Forde (Simon Fraser University, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Jeffrey Hartgerink (Rice University, United States)
"The Self-Assembly of Heterotrimeric Collagen Helices and Helical Bundles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jeffrey Ruberti (Northeastern University, United States)
"Tension in the Ranks: Cooperative Pulls Drive Initial Matrix Assembly by Human Fibroblasts"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Meghan Martin (Dalhousie University, Canada)
"Differential Development of Collagen in the Fetal Mitral Valve Chordae Tendineae and Leaflet: Unique Lessons for Tissue Engineering"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Matthew Harrington (McGill University, Canada)
"Functionally Graded Interfaces Between Living and Non-living Collagenous Tissues in Mussels"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Growth and Metastasis
Discussion Leader: Julie Di Martino (NYMC, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Raphael Reuten (University of Freiburg, Germany)
"How Cells Guide Chemokine Gradients Inside the Extracellular Matrix"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Ryan Petrie (Drexel University, United States)
"A Ras-Erk Pathway Dictates the Mode of Single Cell 3D Migration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Annalena Dittmann (University of Oulu, Finland)
"Targeting Acute Myeloid Leukemia by the Leukemic Matrisome Interface"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Cynthia Reinhart-King (Vanderbilt University, United States)
"Advanced Glycation End-Products in Tumor Progression"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Thomas Cox (Garvan Institute of Medical Research, Australia)
"Targeting Lysyl Oxidase Mediated Collagen Cross-Linking in Pancreatic Cancer"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Yang Chen (The University of Texas MD Anderson Cancer Center, United States)
"Distinct Functions of Collagen I in Development and Pancreatic Cancer at Single-Cell Level"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jaye Gardiner (Fox Chase Cancer Center, United States)
"Examining the Unconventional Role of Ang–Tie2 Signaling in Pancreatic CAF/ECM Unit Function"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Collagens: Systems Approaches, Networks and Interactomes
Discussion Leader: Delfien Syx (Ghent University, Belgium)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Sylvie Ricard-Blum (Université Claude Bernard Lyon 1, France)
"The Interaction Network of Membrane Collagens."
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Valerio Izzi (University of Oulu, Finland)
"Computational Matrix Biology: Building New Tools for the ECM Community"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Sara Zanivan (CRUK Beatson Institute, United Kingdom)
"Metabolic Control of ECM Production in Tumours"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Yoshihiro Ishikawa (University of California, San Francisco, United States)
"Determining the Collagen IV Biosynthetic Interactome and the Differential Roles of Collagen Modifying Enzymes"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Fibrosis and Tissue Repair
Discussion Leader: Sergey Leikin (National Institutes of Health, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Boris Hinz (St. Michael's Hospital and University of Toronto, Canada)
"Matrix Mediated Myofibroblast Memory"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Edna Cukierman (Fox Chase Cancer Center, United States)
"Fibroblastic Cell/ECM Functional Units in Cancer"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Mark Feinberg (Brigham and Women's Hospital/Harvard Medical School, United States)
"Perivascular Fibrosis: Rejuvenating Blood Vessels by Targeting T Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Jagdeep Nanchahal (University of Oxford, United Kingdom)
"Localised Fibrosis - From the Lab to the Clinic"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Alexander Nystrom (University Medical Center Freiburg, Germany)
"Instructor and Enforcer: Contextuality of Collagen VII in Tissue Repair"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Aubrie Stricker (Vanderbilt University, United States)
"Piezo Initiates Transient Production of Collagen IV to Repair Damaged Basement Membranes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Oula Norman (University of Oulu, Finland)
"Contribution of Collagen XIII to Lung Function and Pulmonary Fibrosis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Musculoskeletal Development and Pathology
Discussion Leader: Antonella Forlino (University of Pavia, Italy)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Marc Wein (Massachusetts General Hospital, United States)
"Signaling Networks that Control Osteocyte Differentiation and Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Paul Eckhard Witten (Ghent University, Belgium)
"More Bone with Less Minerals. A New Approach to Reverse Bone Loss."
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Shireen Lamande (Murdoch Children's Research Institute, Australia)
"Modelling Collagen Skeletal Disorders Using Human Induced Pluripotent Stem Cells"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Samuele Metti (University of Padova, Italy)
"Antxr2 Regulates Collagen VI Homeostasis In Skeletal Muscle"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure