May 28
Sunday evening |
DIVERSITY ANALYSIS/COMPUTATIONAL ASPECTS |
|
Discussion Leader: Jack Hodges |
| 7:30 pm (19.30) |
Introduction |
| 7:40 (19.40) |
Tim Mitchell (Cambridge Discovery Chemistry)
Computational Strategies and Methods for Building Drug-Like Libraries |
| 8:25 |
Discussion |
| 8:35 |
Robert S. Pearlman (University of Texas)
Diversity and Lead Follow-up in a Low-Dimensional Chemistry Space |
| 9:20 |
Discussion |
May 29
Monday morning |
LIBRARY DESIGN AND QUALITY |
|
Discussion Leader: John S. Kiely |
| 9:00 (9.00) |
Simon K. Kearsley (Merck Research Laboratories)
Virtual Validation of Combinatorial Libraries |
| 9:45 |
Discussion |
| 9:55 |
Coffee Break |
| 10:30 |
Conference Photograph |
| 10:45 |
Ian Hughes (SmithKline Beecham)
An Integrated Process for High Throughput QC and Purification |
| 11:25 |
Discussion |
| 11:35 |
Larry K. Truesdale (Alanex Division, Agouron Pharmaceuticals)
The Criteria for Quality Libraries |
| 12:20 |
Discussion |
May 29
Monday afternoon |
POSTERS |
| 4:00- 5:30 |
Poster Session |
May 29
Monday evening |
COMBINATORIAL CHEMISTRY - Some Industrial Experiences |
|
Discussion Leader: Hans Ulrich Stilz |
| 5:30 |
Pierfausto Seneci (GlaxoWellcome-Italy)
A Survey of Combinatorial Technology Activities in GlaxoWellcome-Italy |
| 6:10 |
Discussion |
| 6:20 |
Thomas J. Sowin (Abbott Laboratories)
Large Mix and Split Combinatorial Libraries for Random Lead Generation - The Abbott Experience |
| 6:50 |
Discussion |
| 7:00 |
Thomas J. Caulfield (Aventis Pharma)
New Technology for the Semi Automated Production of Large Libraries |
| 7:30 |
Discussion |
May 30
Tuesday morning |
RESINS, LINKERS AND REAGENTS |
|
Discussion Leader: Hicham Fenniri |
| 9:00 |
Mark Bradley (University of Southampton)
New Resins and Supports for Solid Phase and Solution Phase Synthesis |
| 9:45 |
Discussion |
| 9:55 |
Stefan Braese (RWTH Aachen)
New Techniques in Combinatorial Chemistry: Synthesis of Biologically Active Compounds on Solid Support Using New Linker Types |
| 10:40 |
Discussion |
| 10:50 |
Coffee Break |
| 11:20 |
Oral Presentation of Posters |
| 11:40 |
Kevin Burgess (Texas A&M University)
Solid Phase Synthesis of ß-Turn Mimics of Neurotropin Hot-spots |
| 12:25 |
Discussion |
May 30
Tuesday afternoon |
POSTERS |
| 4:00-5:30 |
Poster Session |
May 30
Tuesday evening |
SYNTHETIC METHODS DEVELOPMENT |
|
Discussion Leader: Stephen W. Kaldor |
| 5:30 |
Günther G. Jung (University of Tübingen)
Methods Development and Feasibility Studies for Organic Compound Collections |
| 6:15 |
Discussion |
| 6:25 |
Morten Meldal (Carlsberg Laboratory)
Solid Phase Organopeptidic Libraries - The Use of Enzyme Permeable Resins for the "One Bead Two Compounds" Enzyme Inhibitor Assay |
| 7:10 |
Discussion |
| 7:20 |
Oral Presentation of Posters |
May 31
Wednesday morning |
1.COMPLEX MOLECULE COMBINATORIAL CHEMISTRY
2. COMBICHEM EDUCATION |
|
Discussion Leader: A. Ganesan |
| 9:00 |
Lutz Weber (Morphochem AD)
Algebraic Chemistry and Chemical Diversity |
| 9:45 |
Discussion |
| 9:55 |
Peter H. Seeberger (Massachusetts Institute of Technology)
Carbohydrate Scaffolds and Oligosaccharide Libraries |
| 10:40 |
Discussion |
| 10:50 |
Coffee Break |
| 11:20 |
Oral Presentation of Posters |
| 11:40 |
Combinatorial Education Panel and Open Discussion |
May 31
Wednesday evening |
CASE STUDIES OF SUCCESSFUL COMBINATORIAL CHEMISTRY |
|
Discussion Leader: Samuel W. Gerritz |
| 5:30 |
Michael R. Wiley (Eli Lilly and Company)
Discovery of New Anticoagulants through the Integration of High Throughput Screening, Parallel Synthesis and Structure-based Design |
| 6:15 |
Discussion |
| 6:30 |
Lorin A. Thompson (DuPont Pharmaceuticals)
Parallel Synthesis of A-ß Secretion Inhibitors |
| 7:15 |
Discussion |
June 1
Thursday morning |
COMBICHEM IN MATERIALS SCIENCE, Biology and Catalysis |
|
Discussion Leader: Mark Bradley |
| 9:00 |
Andrei K. Yudin (University of Toronto)
Spatially Addressable Electrolysis Platforms and Chemistry on Conducting Supports |
| 9:40 |
Discussion |
| 9:50 |
Eric M. Gordon (Sunesis Pharmaceuticals)
Applications of Target-Directed Fragment Assembly to Drug Discovery |
| 10:25 |
Discussion |
| 10:35 |
Coffee Break |
| 10:55 |
Anthony W. Czarnik (Illumina, Inc.)
The Promise of 60,000,000 Genotyping Experiments in One Microtiter Plate |
| 11:35 |
Discussion |
| 11:45 |
Henry Weinberg (Symyx Technologies)
Combinatorial Methodologies for Catalyst Screening and Development |
| 12:30 |
Discussion |
June 1
Thursday evening |
COMPLEX MOLECULE COMBINATORIAL CHEMISTRY (contd.) |
|
Discussion Leader: Thomas R. Beattie |
| 5:30 |
Steven V. Ley (Cambridge University)
Use of Solid Phase Reagents in Multi-step Organic Synthesis |
| 6:25 |
Discussion |
| 6:35 |
Election Candidate Speeches and Voting |
| 6:50 |
Business Meeting |
