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| 2:00-11:00pm | Arrival & Registration |
| 6:00pm | Dinner |
Session #1
7:30-9:30pm | Diversity Analyses / Library Control |
|
| Discussion Leader: Derrick Maclean |
| 7:30-7:40pm | Introductions & Organizational Announcements |
| 7:40-8:20pm | Eric Martin, Chiron
Combinatorial Library Design with OSPPREYS: Pharmacophore Diversity in Large Virtual Libraries of Flexible Molecules |
| 8:20-8:35pm | Discussion |
| 8:35-9:15pm | Carleton Sage, Lion Bioscience
Predictive absorption and metabolism programs for library structures |
| 9:15-9:30pm | Discussion |
|
| 7:30am-8:30am | Breakfast |
| 8:30am-9:00am | Conference Photo |
Session #2
9:00am-12:30pm | Virtual and Actual Screening of Combinatorial Libraries |
|
| Discussion Leader: Eric Martin |
| 9:00am-9:10am | Chair's Welcome & Announcements |
| 9:10am-9:55am | Mohammed Afshar, RiboTargets
Molecular docking of large compound libraries against both protein and RNA targets |
| 9:55am-10:10am | Discussion |
| 10:10am-10:40am | Coffee Break |
| 10:40am-11:20am | Daniel Parish, Roche
Analysis of compound selection efficiency from bcut metric-derived chemistry spaces |
| 11:20am-11:35am | Discussion |
| 11:35am-12:15pm | Steve Rodems, Aurora
Ultra-high throughput screening |
| 12:15pm-12:30pm | Discussion |
| 12:30pm-1:30pm | Lunch |
| 1:30pm-4:30pm | Free Time |
| 4:30pm-6:00pm | Poster Session #1 |
| 6:00pm-7:00pm | Dinner |
Session #3
7:30-9:30pm | Actual Screening of Combinatorial Libraries |
|
| Discussion Leader: Sam Gerritz |
| 7:30pm-8:10pm | Sam Gerritz, Bristol-Myers Squibb
Probing the reactivity of solid supports |
| 8:10pm-8:25pm | Discussion |
| 8:25pm-9:05pm | Dave Burns, Abbott
Continueous Format Screening of Combinatorial Libraries |
| 9:05pm-9:30pm | Discussion |
|
| 7:30am-8:30am | Breakfast |
Session #4
9:00am-12:30pm | Libraries for Chemical and Biological Research |
|
| Discussion Leader: Tom Sowin |
| 9:00am-9:10am | Chair's Announcements |
| 9:10am-9:50am | David Austin, Yale Univ
Template-Based Chemical Libraries for the Investigation of Macromolecular/Ligand Specificity and Selectivity |
| 9:50am-10:05am | Discussion |
| 10:05am-10:30am | Coffee Break |
| 10:30am-11:15am | Dennis Hall, Univ of Alberta Canada
Polyamine Libraries Binding |
| 11:15am-11:30am | Discussion |
| 11:30am-12:15am | Matt Shair, Harvard
Diversity-Oriented Approaches to Chemistry and Biology |
| 12:15am-12:30am | Discussion |
| 12:30pm-1:30pm | Lunch |
| 1:30pm-4:30pm | Free Time |
| 4:30pm-6:00pm | Poster Session #2 |
| 6:00pm-7:00pm | Dinner |
Session #5
7:30pm-9:30pm | Targeted Libraries for Optimization and SAR Development |
|
| Discussion Leader: , David Austin |
| 7:30pm-8:15pm | Volkmar Wehner, Aventis Germany
Parallel and automated synthesis in the lead optimization of VLA-4 antagonists |
| 8:15pm-8:30pm | Discussion |
| 8:30pm-9:15pm | Scott Harbeson, Vertex
Parallel Synthesis in Lead Identification and Lead Optimization: IL-1b Converting Enzyme and Hepatitis C Protease |
| 9:15pm-9:30pm | Discussion |
|
| 7:30am-8:30am | Breakfast |
Session #6
9:00am-12:30pm | Combinatorial Chemistry Intersection with Genomics/Proteomics |
|
| Discussion Leader: Hans-Ulrich Stitz |
| 9:00am-9:10am | Chair's Announcements |
| 9:10am-9:55am | Jacque Fetrow, GeneFormatics
Protein structures and structural motifs: linking drug discovery to genome sequences |
| 9:55am-10:10am | Discussion |
| 10:10am-10:35am | Coffee Break |
| 10:35am-11:15am | Tim Hughes, Univ Toronto & Rosetta
Using a compendium of DNA microarray expression profiles to identify pathways inhibited by small molecules |
| 11:15am-11:30am | Discussion |
| 11:30am-12:15pm | Albrecht Berkessel, Univ of Koln
Biomimetic Catalysis by Combinatorial Methods |
| 12:15pm-12:30pm | Discussion |
| 12:30pm-1:30pm | Lunch |
| 1:30pm-4:30pm | Free Time |
| 4:30pm-6:00pm | Poster Session #1 |
| 6:00pm-7:00pm | Dinner |
Session #7
7:30-9:30pm | Methods in Solid Phase Synthesis |
|
| Discussion Leader: Tom Beattie |
| 7:30pm-8:00pm | Greg Roth, Boehringer-Ingelheim Conneticut
Microwave technology as a method of streamlining parallel synthesis library generation |
| 8:00pm-8:10pm | Discussion |
| 8:10pm-8:40pm | Shelli McAlpine, San Diego State U
The investigation of bead properties and recent progress on Virginiamycin libraries |
| 8:40pm-8:50pm | Discussion |
| 8:50pm-9:30pm | Derrick MacClean, Affymax
So, just what is a "combinatorial library" anyway? Towards a systematic representation of libraries through structure and terminology: The efforts of the IUPAC working party on combinatorial chemistry |
|
| 7:30am-8:30am | Breakfast |
Session #8
9:00am-12:00pm | High Throughput Analyses (MS & NMR) & Purification |
|
| Discussion Leader: Kevin Burgess |
| 9:00am-9:10am | Chair's Announcements |
| 9:10am-9:55am | Dan Kassel, DuPont San Diego
High speed HPLC purification SCF quantifiction |
| 9:55am-10:10am | Discussion |
| 10:10am-10:35am | Coffee Break |
| 10:35am-11:20am | Bud Weller, BMS
High Throughput analysis coupled with HT synthesis |
| 11:20am-11:35am | Discussion |
| 11:35am-12:15pm | John Hartwig, Yale Univ
High Throughput Screening of Catalysts for C-C and C-N Bond Formation |
| 12:15pm-12:30pm | Discussion |
| 12:30pm-1:30pm | Lunch |
| 1:30pm-4:30pm | Free Time |
| 4:30pm-6:00pm | Poster Session #2 |
| 6:00pm-7:00pm | Dinner |
Session #9
7:30-9:30pm | Combinatorial Technologies for Materials Science, Catalysis, and Pharma Applications |
|
| Discussion Leader: John Kiely |
| 7:30pm-8:10pm | E. S. Yeung, Iowa St Univ
Novel Measurement schemes for screening combinatorial heterogeneous and homogeneous reactions |
| 8:10pm-8:20pm | Discussion |
| 8:20pm-9:30pm | Business Meeting & Elections for CoChair 2002 |
