| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Medicinal Chemistry |
| Discussion Leader: Sam Gerritz (Bristol Meyers Squibb, USA) |
| 7:30 pm - 8:10 pm | Dennis Heyer (GlaxoSmithKline, USA)
"Design and Preparation of Solid-Phase Benzmidazole-Derived Chemical Libraries: Application to 7-TM-Based Drug Targets" |
| 8:10 pm - 8:50 pm | Robin Carr (Astex Technology, UK)
"The Development and Application of High Throughput X-ray Crystallographic Screening of Drug Fragments, A Novel Approach for Rapid Lead Generation" |
| 8:50 pm - 9:30 pm | Joe Guiles (Aventis, USA)
"Influence of Combinatorial Tools on Synthetic Strategy for Lead Optimization" |
| 9:30 pm | Wine and cheese reception |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Self Assembled Libraries |
| Discussion Leader: Philippe Breton (L'Oréal, France) |
| 9:00 am - 10:00 am | Jean-Marie Lehn (Laboratoire Chimie Supramoleculaire, France)
"From Supramolecular Self-Organization to Dynamic Combinatorial Chemistry" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:30 am | Alexey V. Eliseev (Therascope AG, Germany)
"Dynamic Libraries as a Tool for Drug Discovery" |
| 11:30 am - 12:30 pm | Benjamin L. Miller (University of Rochester, USA)
"Identification of RNA-binding Compounds from Dynamic Combinatorial Libraries" |
| 12:45 pm | Group Photo then lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Synthetic Methodologies 1 |
| Discussion Leader: Mike Ohlmeyer (Pharmacopeia, USA) |
| 7:30 pm - 8:10 pm | Mark Bradley (University of Southampton, UK)
"Beads and Assays in Combinatorial Chemistry" |
| 8:10 pm - 8:50 pm | Chris Abell (University of Cambridge, UK)
"Enriching the Combinatorial Toolbox" |
| 8:50 pm - 9:30 pm | Takayuki Doi (Tokyo Institute of Technology, Japan)
"Solid-Phase Synthesis of a Combinatorial Library of
Natural and Unnatural Products" |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Polymers and Luminescent Materials |
| Discussion Leader: Andrew J. Sutherland (University of Aston) |
| 9:00 am - 9:50 am | Geoff Coates (Cornell University, USA)
"Discovery and Development of New Polymerization Catalysts Using Combinatorial Methods" |
| 9:50 am - 10:30 am | Hicham Fenniri (Purdue University, USA)
"A One-barcode-one-compound Deconvolution Strategy Based on Spectroscopically-encoded Resins" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:50 am | Chad A. Mirkin (Northwestern, USA)
"Dip-Pen Nanolithography and Combinatorial Nanotechnology" |
| 11:50 am - 12:30 pm | Maciek Adamczyk (Abbott, USA)
"Chemiluminescent Detection: Follow the Bright Lights"" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Synthetic Methodologies 2 |
| Discussion Leader: A. Ganesan (University of Southampton) |
| 7:30 pm - 8:10 pm | Richard Larock (Iowa State University, USA)
"Promising Combinatorial Approaches to Carbocycles and Heterocycles Using Palladium- and Iodine-Promoted Cyclizations" |
| 8:10 pm - 8:50 pm | Shankar Balasubramanian (University of Cambridge, UK)
"Designer Linkers for Polymer Supported Chemistry" |
| 8:50 pm - 9:30 pm | Adam Golebiowski (Proctor and Gamble, USA)
"Development of Novel Scaffolds for Peptide b-Turn Mimetic Libraries" |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Homogeneous Catalysis |
| Discussion Leader: Mark Bradley (University of Southampton) |
| 9:00 am - 9:50 am | Koichi Mikami (Tokyo Institute of Technology, Japan)
"Asymmetric Activation: Super High-Throughput Screening of
Chiral Ligands and Activators by HPLC-CD/UV and HPLC-OR/RIU" |
| 9:50 am - 10:30 am | David B. Berkowitz (University of Nebraska, USA)
"Toward an In Situ Enzymatic Screening (ISES) Approach to Catalysis" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:50 am | Dalibor Sames (Columbia, USA)
"Design of New Fluorogenic Probes for Organic Reactions" |
| 11:50 am - 12:30 pm | George Li (CombiPhos Catalysts, USA)
"Combinatorial Catalysis Applications: The First Homogeneous Combinatorial Catalysts for Industrial Processes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 (if necessary) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Factorial Design in Process Chemistry |
| Discussion Leader: Christine Brotherton-Pleiss (Roche Bioscience, USA) |
| 7:30 pm - 8:10 pm | Rolf Carlson (University of Tromsø, Norway)
"New Strategies for Screening Discrete Variations in Organic Synthesis" |
| 8:10 pm - 8:50 pm | Martin R Owen (GlaxoSmithKline, UK)
"The Benefits of Applying Experimental Design (and the risks of applying it too late or not at all)" |
| 8:50 pm - 9:30 pm | Gary Proehl (Eisai Research Institute, USA)
"Chemical Process Optimization Using Design of Experiments and Laboratory Automation" |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Peptidomimetics |
| Discussion Leader: Kevin Burgess (Texas A & M University, USA) |
| 9:00 am - 9:50 am | Andrew Hamilton (Yale University, USA)
"Synthetic Strategies for Targeting Protein-Protein Interactions" |
| 9:50 am - 10:30 am | Kip Guy (University of San Francisco, USA)
"A Tale of Two Helicies" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:50 am | Victor Hruby (University of Arizona, USA)
"Combinatorial Chemistry: Some Critical Issues" |
| 11:50 am - 12:30 pm | Business Meeting |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Combinatorial Techniques |
| Discussion Leader: Tom Sowin (Abbott, USA) |
| 7:30 pm - 8:30 pm | Dan Singleton (Texas A & M University, USA)
"Combinatorial Determination of Isotope Effects" |
| 8:30 pm - 9:30 pm | Horst Kessler (University of Munich, Germany)
"NMR in Medicinal Chemistry: Screening, Design and Combinatorial Chemistry" |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
